DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	512	Identity:	103/512 - (20%)
Similarity:	194/512 - (37%)	Gaps:	130/512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDVDTALLTIG-YGLGQV-IIFMVSFFIYMYSVTESM---------------------------T 39
            |:|:.|...:| .|:.|: :.|:::..:.:|..||::                           :
Human     1 MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQS 65

  Fly    40 AG-------YLVVLTSCE----------FDTSPKEKTLLAN-----SLLGGMVASGLFIGF---- 78
            ||       :|:.....|          |.:...|..|:||     |.......||:|:|.
Human    66 AGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFG 130

  Fly    79 -LADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGE-FHAIK 141
             |:||:|||.|........:.|::.:...|.....:|.|.:||.....::.:....|.| .....
Human   131 QLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAY 195

  Fly   142 WRPITVAICSQSQGLALIYCPLVAMAILPNNFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICL 206
            |     |:.....|| .....:...|:|          .|.:|.||.|.:...:.|.:..:....
Human   196 W-----ALAGSIGGL-FFAVGIAQYALL----------GYFIRSWRTLAILVNLQGTVVFLLSLF 244

  Fly   207 VPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSSTNDQEGFWKTVWYEYKLLFS 271
            :||:|.:|.|..|..:|..||..|.:.|||.  ....:|:...:.:..:.|.:..: :.|::|..
Human   245 IPESPRWLYSQGRLSEAEEALYLIAKRNRKL--KCTFSLTHPANRSCRETGSFLDL-FRYRVLLG 306

  Fly   272 KPHVFKF--FICLFLIFGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGT 334
            ...:..|  |:|..:.:|:..::..||  ..:..|:..||   |.::    |::
Human   307 HTLILMFIWFVCSLVYYGLTLSAGDLG--GSIYANLALSG---LIEI----PSY----------- 351

  Fly   335 DSESPKCNDEMTNLIDPVYYG-------FTYIGCFILASVLVHWMTRKYVIALHILISMILGISL 392
                |.|    ..||:..::|       |..:|.  ||.::|.::..|....:..:::   ..||
Human   352 ----PLC----IYLINQKWFGRKRTLSAFLCLGG--LACLIVMFLPEKKDTGVFAVVN---SHSL 403

  Fly   393 NIMKQPTVVLIFFVLMMVLPGVLIPLATSVLVDCLPVNLRGKALCMVRSLARFGGVL 449
            :::.:.|:...|.:         :.:.||.|   .|..:|...|......:|.||::
Human   404 SLLGKLTISAAFNI---------VYIYTSEL---YPTVIRNVGLGTCSMFSRVGGII 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	97/492 (20%)
		MFS	23..>208	CDD:119392	45/239 (19%)
		MFS	354..>482	CDD:304372	20/103 (19%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	84/402 (21%)
		MFS_1	111..450	CDD:284993	84/402 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840