DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001034460.2	Gene:	Slc22a15 / 242126	MGIID:	3607704	Length:	544	Species:	Mus musculus

Alignment Length:	561	Identity:	120/561 - (21%)
Similarity:	197/561 - (35%)	Gaps:	153/561 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDVDTALLTIG-YGLGQV-IIFMVSFFIYMYSVTESM---------------------------T 39
            |:|:.|...:| .||.|: :.|:::..:.:|..||::                           |
Mouse     1 MEVEEAFQAVGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYHWDMADLLPNQSHSNQT 65

  Fly    40 AG-------YLVVLTSCE----------FDTSPKEKTLLAN-----SLLGGMVASGLFIGF---- 78
            .|       :|:.....|          |.:...|..|:||     |.......||:|:|.
Mouse    66 LGKGQAFGDWLLTANGSEIHKHVHFSNSFTSIASEWFLIANRSYKVSAASSSFFSGVFVGVISFG 130

  Fly    79 -LADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGE-FHAIK 141
             |:||:||:.|........:.|:|.:...|.....:|.|.:||.....::.:....|.| .....
Mouse   131 QLSDRFGRRKVYLTGFALDILFAVANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAY 195

  Fly   142 WRPITVAICSQSQGLALIYCPLVAMAILPNNFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICL 206
            |     |:.....|| .....:...|:|          .|.:|.||.|.:...:.|.|..:....
Mouse   196 W-----ALAGSIGGL-FFAVGIAQYALL----------GYFIRSWRTLAVLVNLQGTLVFLLSLF 244

  Fly   207 VPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSSTNDQEGFWKTVWYEYKLLFS 271
            :||:|.:|.|..|..:|..||.:|.:.|||......:|....:|               |:...|
Mouse   245 IPESPRWLYSQGRLSEAEEALYFIAKRNRKLKCTFSLTHPANRS---------------YRATGS 294

  Fly   272 KPHVFKFFICLFLIFGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGTDS 336
            ...:|::.|.|      ..|.|.:.|||             :|.||....|.   .|.|..|
Mouse   295 FLDLFRYRILL------GHTLILMFIWF-------------VCSLVYYGLTL---SAGDLGG--- 334

  Fly   337 ESPKCNDEMTNLIDPVYYGFTYIGCFILASVLVHWMTRKYVIA-------LHILISMIL------ 388
             |...|..::.||:...|..    |..|  :...|..||..:|       |..||.|.|
Mouse   335 -SIYANLALSGLIEIPSYPL----CIYL--INQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDT 392

  Fly   389 GI-------SLNIMKQPTVVLIFFVLMMVLPGVLIPLATSVLVDCLPVNLRGKALCMVRSLARFG 446
            |:       ||:::.:.|:...|.:         :.:.||.|   .|..:|...|......:|.|
Mouse   393 GVFAVVNSHSLSLLGKLTISAAFNI---------VYIYTSEL---YPTVIRNVGLGACSMFSRVG 445

  Fly   447 GVLGSTMIGLFIRVTCDVTFNIFNLCLAICVVLAVFQPKDI 487
            |:: :..:.....|...:.|.:|........:|::..|:.:
Mouse   446 GII-APFVPSLKEVQWSLPFIVFGATGLTSGLLSLLLPETL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	108/503 (21%)
		MFS	23..>208	CDD:119392	46/239 (19%)
		MFS	354..>482	CDD:304372	30/147 (20%)
Slc22a15	NP_001034460.2	MFS	121..469	CDD:119392	96/423 (23%)
Slc22a15	NP_001034460.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..544
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840