DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and SV2C

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	603	Identity:	125/603 - (20%)
Similarity:	220/603 - (36%)	Gaps:	151/603 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AMDVDTALLTIGYGLGQVIIFMVSFFIYMYSVTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLG 67
            |...:..:...|:|..|..:|.|.....|....|....|:  ||.|.|.|      ..:.||..|
Human   135 AQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGF--VLPSAETD------LCIPNSGSG 191

  Fly    68 --------GMVASGLFIGFLADRYGRK--FVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTF 122
                    ||:....|.|.|||:.|||  .:|.:::.|..:|  :|:.:.........|::.|..
Human   192 WLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAF--LSSFVQGYGFFLFCRLLSGFG 254

  Fly   123 LSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVW 186
            :.........:..|..|.:.|...::.......:..||...:|.||:|: .::..:.|:|....|
Human   255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSW 319

  Fly   187 RFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSS 251
            |..::...:|...::|.:..:||:|.||:.|.:.|:|.:.||.|...|.:.....:...:..|..
Human   320 RVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIK 384

  Fly   252 TNDQ----------EGFW--------KT----VWYEYKLLFSKP---HVFKFFICLF-LIFGIFF 290
            |..|          .|.|        :|    :|..:...|:.|   :..|..|..| |.||.:
Human   385 TPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYY- 448

  Fly   291 TSIGLGIWFP-------------VIRNMD-----------------NSGSN-------------- 311
               ||.:|||             :.||::                 ::|..
Human   449 ---GLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSV 510

  Fly   312 -------RLCDL-----VN---NNPTFINHEADDTN-----GTDSESPKCN-------DEMTNLI 349
                   :.|..     ||   .|.|||:...|:|:     ..|||...|:       .::|  .
Human   511 TFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQIT--F 573

  Fly   350 DPVY-----YGFTYIGCF------ILASVLVHWMTRKYVIALHILISMILGISLNIMKQPTVVLI 403
            |..|     |...::|..      |::::|:..:.|..::...:::|   |||...:...|...:
Human   574 DDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLS---GISCFFLWFGTSESM 635

  Fly   404 FFVLMMVLPGVLIPLATS---VLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVT 465
            ...::.:..|:.|....|   |.|:..|.:.|......:.:|.:...|||:.:.|..:.:|..:.
Human   636 MIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIP 700

  Fly   466 F----------NIFNLCL 473
            .          .:..|||
Human   701 ILLASTVLVCGGLVGLCL 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	115/550 (21%)
		MFS	23..>208	CDD:119392	44/195 (23%)
		MFS	354..>482	CDD:304372	26/139 (19%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	125/603 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128
		MFS	155..719	CDD:119392	121/583 (21%)
		Pentapeptide_3	507..561	CDD:290309	12/53 (23%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920