DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	485	Identity:	99/485 - (20%)
Similarity:	182/485 - (37%)	Gaps:	120/485 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSCEFDTSP-------KEKTLLA---------------NSLLGGMVASGLFIGF-----LADRYG 84
            |..|.||.|       .:.|.|:               ||:...:..:|:|||:     |:|::|
Mouse   107 TVTEPDTEPCVDGWVYDQSTFLSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFG 171

  Fly    85 RKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAI 149
            ||.:...:|:.........|..|.......:|.:.|.|.|.:.:.....:.|:.:.|::.:.:|:
Mouse   172 RKLIFTCSLLKMAITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMAL 236

  Fly   150 CSQSQGLALIYCPLVAMAILPNNFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFL 214
            ...:.|:.......:|.|               .|.|..|.:...:|.:|.|:....:.|:..:|
Mouse   237 IFIASGVGQTLLGGLAFA---------------FRNWHHLQLALSVPMFLLLIPTRWLSESARWL 286

  Fly   215 MSVNRPDKALLALKWICRMNRKKWEDVDITLSEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFF 279
            :..|:|.|:|..||....:||.|.....:||...|:...:          |.:...:||.....|
Mouse   287 IMANKPQKSLKELKKAACVNRIKNSGDALTLEVVKTIMKE----------ELEAAQTKPSPLDLF 341

  Fly   280 --------ICL--FLIFGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVN----NNPTFINHEADD 330
                    |||  |:.|....:.:||                    |:|    :|..|:
Mouse   342 RTPNLRKRICLLSFVRFVSVMSLLGL--------------------LINIQYLSNNVFL------ 380

  Fly   331 TNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFILASVLVHWMTRKYVIALHILISMILGIS-LNI 394
                    .:|           .||...|...:|.:..:::|.|:..   .::...:|||| |.:
Mouse   381 --------LQC-----------LYGVVCIPANVLGNFSMNYMGRRMT---QLIFMSVLGISILAV 423

  Fly   395 MKQPTVVLIFFVLMMVLPGVLIPLA-TSVLV---DCLPVNLRGKALCMVRSLARFGGVLGSTMIG 455
            :..|..:.|..|.:..|.|.:...: ||.||   :.:|..:|..||.:|......||.| |.::.
Mouse   424 VFLPQEMQILRVFLSTLGGAISSASITSTLVHANELVPTIIRATALGVVGIAGSAGGAL-SPLLM 487

  Fly   456 LFIRVTCDVTFNIFNLCLAICVVLAVFQPK 485
            :....:..:.:.|:.:...:..::|:..|:
Mouse   488 ILTTYSASLPWIIYGILPFLGGLVALLLPE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	95/449 (21%)
		MFS	23..>208	CDD:119392	37/187 (20%)
		MFS	354..>482	CDD:304372	31/132 (23%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	99/485 (20%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840