DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33233 and Sv2b

DIOPT Version :9

Sequence 1:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_476555.1	Gene:	Sv2b / 117556	RGDID:	619716	Length:	683	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	121/575 - (21%)
Similarity:	213/575 - (37%)	Gaps:	130/575 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AMDVDTALLTIGYGLGQVIIFMVSFFIYMYSVTESMTAGYLVVLTSCEFD--TSPKEKTLLANSL 65
            |...:|.:...|:|..|..:|.|.....|....|.....:  .|.|.|.|  .|..:|.:|...:
  Rat    92 AHQYETIIDECGHGRFQWTLFFVLVLALMADGVEVFVVSF--ALPSAEKDMCLSSSKKGMLGLIV 154

  Fly    66 LGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQ 130
            ..||:|....:|.|||:.|||.|:.::|....||:.:|:.:....:....|:|.|..:.....:.
  Rat   155 YLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIV 219

  Fly   131 VGFLGEF-------HAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWR 187
            ..:..||       ..:.|    :.|...:.|   ||...:|.:|:|: .:...:.::|:...||
  Rat   220 FAYFSEFLSREKRGEHLSW----LGIFWMTGG---IYASAMAWSIIPHYGWGFSMGTNYHFHSWR 277

  Fly   188 FLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWI--CRMNRKKWEDVDITLSEEKS 250
            ..::...:|..:::|.:..:||:|.||:.:.:.|:|.:.||.:  ..|..|...:...|:|..|:
  Rat   278 VFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKT 342

  Fly   251 STNDQE--------GFW------------KTVWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGL 295
            .....|        |.|            |.||.........|:.....|...:.|.:..:..||
  Rat   343 PKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGL 407

  Fly   296 GIWFP-VIR--------------------------NMDNSGSNRLCDLVNN------------NP 321
            .:||| :||                          .|:|. .::...|||:            ..
  Rat   408 TVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQ-IHQHGKLVNDKFIKMYFKHVLFED 471

  Fly   322 TFINH-EADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFILASV------------------ 367
            ||.:. ..:|...||:....|..|.|...:...|...:|.|..:.|.
  Rat   472 TFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFIDCRFINSTFLEQKEGCHMDFEEDNDF 536

  Fly   368 ---LVHWMTRKYVIALHILISMI---------LGISLNIMKQPTVVLIFFVLMMVLPGVLIP--- 417
               ||.::....|:..:|:.:::         :|.|:.|    :.|..||:........:|.
  Rat   537 LIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLI----SAVCCFFLFFGNSESAMIGWQC 597

  Fly   418 --LATS---------VLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVT 461
              ..||         :.|:..|.|.|..|..::..|.:.|.:||:|:...|:.:|
  Rat   598 LFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKLGAILGNTIFASFVGIT 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	112/544 (21%)
		MFS	23..>208	CDD:119392	44/194 (23%)
		MFS	354..>482	CDD:304372	29/152 (19%)
Sv2b	NP_476555.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72
		synapt_SV2	8..683	CDD:130366	121/575 (21%)
		MFS	112..>305	CDD:119392	48/201 (24%)
		MFS	534..>675	CDD:119392	25/123 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920