DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and KALRN

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	XP_006713873.1	Gene:	KALRN / 8997	HGNCID:	4814	Length:	2988	Species:	Homo sapiens

Alignment Length:	2606	Identity:	471/2606 - (18%)
Similarity:	883/2606 - (33%)	Gaps:	785/2606 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 IQLVIALLQSPEKIYIKVVELEPKITALGENLDESLRMQREHDETLRNLQSLPGPMDEFVQKADK 171
            :|.|:..:::..:.::.      |.|.:|::|..:..:|:.||:.....|:.....|:.::.|::
Human   547 VQQVLDWIENHGEAFLS------KHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQ 605

  Fly   172 LLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILCTQFHDKMTQCFRKMDQLELACEETL 236
            |..:.....|.:...|..|.:..||.:..::.|:.||.:...||....:.:..|:.|:....|.:
Human   606 LAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDV 670

  Fly   237 HPPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQLEEL-----EKLETLDTRPEHIKRDA 296
            ....|..|||.:.:|:|.:...|...:..:|:|.:|:.||...     |..|..|:...:.|...
Human   671 CADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPH 735

  Fly   297 TRAVHQVQQWLEALHDRRNSLELAWQTRKIQMEQCLALALLGRELVDLEAALQQARMEL------ 355
            :.::..::..|:.|.|.:..:|..:..|||:::..|.|.:..:..:::.|.|.....:|
Human   736 SSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND 800

  Fly   356 -NTMYSLGECEHTANEMLTKYREWKQQALLLRDRALKITRAKEKVQSAGHFTEEDACARAYAVLS 419
             ||     |....|.:.|.::.|.|   |.:.:...::.:..:.:..  :.||..|        |
Human   801 FNT-----EDLTLAEQRLQRHTERK---LAMNNMTFEVIQQGQDLHQ--YITEVQA--------S 847

  Fly   420 G----CTEHLDLVDQREHWLHQSREFFAKAEHTVSVLEKLELELTSVKLPPHSPESYAMFSKVDR 480
            |    |.:.:||..|.:..|    ||..:.:|        ||||
Human   848 GIELICEKDIDLAAQVQELL----EFLHEKQH--------ELEL--------------------- 879

  Fly   481 DVRNFTEEPLRLGYGILDEVGRTQPETQGVKRVLDELENRKVYIQGICANSSEDQQKVQRALSEF 545
                                                             |:.:..:::::.|.
Human   880 -------------------------------------------------NAEQTHKRLEQCLQ-- 893

  Fly   546 LNH----HNELLAWLRASGQHQLQQSVDMGGNLQQAKQFLLQHHELMQDLEIKGELINLLLESI- 605
            |.|    ..::|.|:| :|:..|..|:....:|.:|:| |.:.||..|          |.:||:
Human   894 LRHLQAEVKQVLGWIR-NGESMLNASLVNASSLSEAEQ-LQREHEQFQ----------LAIESLF 946

  Fly   606 ------KVHLESLSPQER---------YDVDSKAESLHK---HWIELKDLVLKRVDYVSLL---I 649
                  |.|..:|..|::         ||.|:..|...|   ||   :.|:||..|.:.|:   :
Human   947 HATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHW---QQLMLKMEDRLKLVNASV 1008

  Fly   650 DFFELANELSSQLDNLQRQLQQTPD-------------------------EHKLQFLQATWTGIA 689
            .|::.:.::.|.|::|:::.::..|                         |.|..||:|......
Human  1009 AFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARR 1073

  Fly   690 STFGELKSRGQRFINLKIVDPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTS--------- 745
            :....||...:..:::..|..:  |:...|.|:..|::..:|:..|   |..||..
Human  1074 NAEVFLKYIHRNNVSMPSVASH--TRGPEQQVKAILSELLQRENRV---LHFWTLKKRRLDQCQQ 1133

  Fly   746 -IAEKREVEYLLEKVMSDNE------ETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVI 803
             :..:|..:..|:.:....|      .:..::|:...:|...:....|.:||    |:||:..:|
Human  1134 YVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQ----TKEKVKLLI 1194

  Fly   804 Q----------------------------DIERAQDEIQQRIQTTLGIQTKDQPSLAKIEQVINN 840
            |                            |......:.:..::..||:.|:|...| :::.:..:
Human  1195 QLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDL-ELDIIPAS 1258

  Fly   841 LRMLKAKLDGIKYDYRT-----------LVESVIQFLENIVQLRREIDDYFARQQKEPASGADR- 893
            |...:.||....::...           ::..::|..:..|   |::.:.......|..||.:.
Human  1259 LSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYV---RDLHECLETYLWEMTSGVEEI 1320

  Fly   894 -------------------------SIAEHEKFRD------QCM----DKFRSLITQSELLIDRV 923
                                     .:.|.||:..      .|.    |||:..:|..:...|..
Human  1321 PPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSN 1385

  Fly   924 R-VLEPPG------------AREIDT------DRILK---LLENLRLHFESNSSARMSTLERLEK 966
            : :||..|            |..|.:      .||.|   ||:.|....|.........||.:..
Human  1386 QLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLS 1450

  Fly   967 IEQFRSD------LEDIDRSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTI---ECSM-- 1020
            :.:..:|      ||..|.:||...:.:.:      |:.......||..:..||.:   |.|:
Human  1451 VPKKANDAMHVSMLEGFDENLDVQGELILQ------DAFQVWDPKSLIRKGRERHLFLFEISLVF 1509

  Fly  1021 PRQLKSTRHQRRW-----------GQTAH--------------TIELLEKRIEKFTESTSQQLFI 1060
            .:::|.:....::           |.|.|              |.....|.:.|.:...::|.:|
Human  1510 SKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWI 1574

  Fly  1061 TNPESERYVKDELRK--------LNEKWQSFKDQVKQKRKSLNQATDFFEVVEKID------AEY 1111
            .|      :::.:::        |.|..|..|...||:..|....      ||.||      ::.
Human  1575 KN------IREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG------VEDIDSQGDGSSQP 1627

  Fly  1112 REISYFYTSVSNKVP------------YLRD---------SVEAGNLVNDIEN----------YV 1145
            ..||....:..|.|.            .|:|         :::.|..|..:|.          ..
Human  1628 DTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRT 1692

  Fly  1146 TSREAALRSKLDSASQC-AHDMNKVS-----SLYNDV-----------------------MNIFQ 1181
            |.|...|...:.|::.| :|..:.|.     .|..|.                       :|...
Human  1693 TERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIH 1757

  Fly  1182 SFIKLKMDINVVQERLKQEQRQKEQRERDARDQAEREKAIKEAEAKERLHREEQSRLENQRQQAA 1246
            |....|...|.:::.|....|:....:.|.  ..:::|.:::......|...:.......:..:|
Human  1758 SSPGPKRSTNTLKKWLTSPVRRLNSGKADG--NIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSA 1820

  Fly  1247 IEQAQRELAARELALREQAVREEEAR------LQAIREQATREQLARE-QAAREEELRIQSLRDI 1304
            .|::::.....|        .:||:.      ::......|:::::.. .|||:....:.:..|:
Human  1821 DEKSKKGWGEDE--------PDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADL 1877

  Fly  1305 ARREEEVRLQNIRDEETRIRREEEERIRRENESRS--------KREEEARIQREEITRL----QT 1357
            ....|::....:..|.:..|...::.....||..:        :.|::|:..|..:..|    ||
Human  1878 VNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQT 1942

  Fly  1358 LRDQVDQQRIVTENIRKDIQVNSIFTELR---------------YASPLFTRPLKDAVSREGDR- 1406
            .:|.|....||.|...|.|:...:..::|               :....|...|:..: :|.||
Human  1943 EKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCI-QEQDRL 2006

  Fly  1407 -------------FVFECE-------VTGTPEPAVEWFKDGISIQ-TNSDYKTTFDKGICRLVIE 1450
                         :|:.|:       :....:...|..|..|:.: |.||:   ..|.|.|:...
Human  2007 AQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDF---LIKPIQRITKY 2068

  Fly  1451 ETFAADSARFSCRASNLVGTCDTNATLSVRENAAEVQ-LVPPRILRFLQSGKATEGSSFQFACVV 1514
            :....|..|:|.:|         ....|..|.|.|:. |||.|....:..|:.   ..|:.....
Human  2069 QLLLKDFLRYSEKA---------GLECSDIEKAVELMCLVPKRCNDMMNLGRL---QGFEGTLTA 2121

  Fly  1515 AGVPLPTVQWFKNDKCIDDSPDYVISYNNG-EATLKFEEVFLEDDAVYTC-----SASNPAGIEH 1573
            .|            |.:.....|||..:.| ::..|...|||.:..|...     .:..|..:..
Human  2122 QG------------KLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFK 2174

  Fly  1574 CSAS---LIVEPLEPTELPSFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLHNGKPFQPRD-- 1633
            .|..   |::|  |..:....|..|.|  ....:::.|:|....|.:..|..::.....| ||
Human  2175 RSIKMNYLVLE--ENVDNDPCKFALMN--RETSERVVLQAANADIQQAWVQDINQVLETQ-RDFL 2234

  Fly  1634 ----SKYEY---GRVTLI-------IPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVKGRLPNETS 1684
                |..||   .|.|.:       :|||.|               ..|:|        :|..:.
Human  2235 NALQSPIEYQRKERSTAVMRSQPARLPQASP---------------RPYSS--------VPAGSE 2276

  Fly  1685 DSEMASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLL--F 1747
            .....|...|..|    ||| :|...|.|              ...||......|::....|  .
Human  2277 KPPKGSSYNPPLP----PLK-ISTSNGSP--------------GFEYHQPGDKFEASKQNDLGGC 2322

  Fly  1748 QGDRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQA------EPATRAQAERQSLP 1806
            .|.....:|::.|........|    |.||.     ::|..:||.      :||:
Human  2323 NGTSSMAVIKDYYALKENEICV----SQGEV-----VQVLAVNQQNMCLVYQPAS---------- 2368

  Fly  1807 KDSQPKFERLL-SDVLADEGEQVVLEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSELGVFKL 1870
             |..|..|..: ..:||...:....| .:.|....:..|    ..|::.:|...::..:
Human  2369 -DHSPAAEGWVPGSILAPLTKATAAE-SSDGSIKKSCSW----HTLRMRKRAEVENTGK------ 2421

  Fly  1871 ILNNVSGDDK------GVYTVKVTNPAGDAKCFSHLIVKSVNAPENRRSSQSSVEIIE----RHQ 1925
              |..:|..|      ...:||.||.:.:::|             :.....:|:||:.    :..
Human  2422 --NEATGPRKPKDILGNKVSVKETNSSEESEC-------------DDLDPNTSMEILNPNFIQEV 2471

  Fly  1926 CPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHWFFNDQPV-----HGHNFLVST--SGERQVL 1983
            .|||.....|....:.:.:..:|.|.|:|.|.:.|...||.:     ....:.||:  |||..:.
Human  2472 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLK 2536

  Fly  1984 TIQKLTHDAVGKISCVAENEAGKATCVAFLNIRGSGLPASSDVQTVSQEHNTESSRVTIKKQTFT 2048
            ....:..|: |..:|:|.|:.|..:..|.:.::  |:||:.: :.::||.:..|  |.::....:
Human  2537 ICNLMPQDS-GIYTCIATNDHGTTSTSATVKVQ--GVPAAPN-RPIAQERSCTS--VILRWLPPS 2595

  Fly  2049 TTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESHHYQELHKSKEMSSPTVQQKSF 2113
            :|....::.|     ..|.....:.|.|      |.....::::...|     ::|.....|...
Human  2596 STGNCTISGY-----TVEYREEGSQIWQ------QSVASTLDTYLVIE-----DLSPGCPYQFRV 2644

  Fly  2114 SFIQSSGANGQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQGADVSMEAIYDGFPSPEIKVEKN 2178
            |      |:....:::|..|:...|  .|.:         |..||           ...|..::|
Human  2645 S------ASNPWGISLPSEPSEFVR--LPEY---------DAAAD-----------GATISWKEN 2681

  Fly  2179 GGQLFEDAHTRISNKCNRVTIELKQVGVGDAGRYAVTASNTVGQSTSTADLVVKKTIFPPVFGRR 2243
                |:.|:|           ||.::|   .||::: ....:.::| ..|:.||
Human  2682 ----FDSAYT-----------ELNEIG---RGRFSI-VKKCIHKAT-RKDVAVK----------- 2715

  Fly  2244 LQAQVSKKGEKLTMEVE-VTGLPEPTVTWLKD--DKPLKDAGISEHRLLAQGNSYRLIIEKAQTT 2305
            ..::..||.|:...|.. :..|..|....|.|  :.|               .||.||:|   ..
Human  2716 FVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESP---------------TSYILILE---LM 2762

  Fly  2306 DSGKYM 2311
            |.|:.:
Human  2763 DDGRLL 2768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103	47/210 (22%)
		SPEC	<504..641	CDD:295325	33/159 (21%)
		COG1340	960..1298	CDD:224259	72/454 (16%)
		RILP-like	<1190..1315	CDD:304877	17/131 (13%)
		MAP7	1233..1365	CDD:283355	23/150 (15%)
		I-set	1390..1479	CDD:254352	20/110 (18%)
		IGc2	1403..1469	CDD:197706	18/87 (21%)
		I-set	1491..1580	CDD:254352	17/97 (18%)
		IGc2	1504..1570	CDD:197706	13/71 (18%)
		I-set	1589..1675	CDD:254352	21/101 (21%)
		Ig	1605..1675	CDD:299845	18/85 (21%)
		I-set	1702..1786	CDD:254352	17/85 (20%)
		Ig	1713..1786	CDD:299845	12/74 (16%)
		I-set	1811..1902	CDD:254352	17/97 (18%)
		Ig	1828..1892	CDD:143165	12/69 (17%)
		I-set	1927..2015	CDD:254352	24/94 (26%)
		IGc2	1940..2005	CDD:197706	18/71 (25%)
		I-set	2142..2231	CDD:254352	16/88 (18%)
		Ig	2158..2231	CDD:299845	13/72 (18%)
		I-set	2238..2325	CDD:254352	16/77 (21%)
		Ig	2254..2324	CDD:299845	13/61 (21%)
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
KALRN	XP_006713873.1	SEC14	41..179	CDD:214706
		SPEC	192..412	CDD:238103
		SPEC	313..538	CDD:238103
		SPEC	539..768	CDD:238103	49/226 (22%)
		SPEC	893..1131	CDD:238103	56/259 (22%)
		SPEC	<1101..1240	CDD:295325	22/145 (15%)
		RhoGEF	1286..1456	CDD:238091	29/172 (17%)
		PH1_Kalirin_Trio_like	1463..1585	CDD:270060	22/133 (17%)
		PH	1496..1581	CDD:278594	14/90 (16%)
		SH3_Kalirin_1	1651..1710	CDD:212786	9/58 (16%)
		SH3-RhoG_link	1708..1934	CDD:293215	32/235 (14%)
		RhoGEF	1935..2105	CDD:279015	39/182 (21%)
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061	29/153 (19%)
		PH	2142..2228	CDD:278594	17/89 (19%)
		SH3_Kalirin_2	2327..2385	CDD:212787	15/77 (19%)
		I-set	2473..2567	CDD:254352	24/94 (26%)
		Ig	2490..2564	CDD:143165	19/74 (26%)
		FN3	2571..2662	CDD:238020	19/115 (17%)
		S_TKc	2686..2940	CDD:214567	26/128 (20%)
		STKc_Kalirin_C	2692..2939	CDD:271017	23/111 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900