DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zormin and KIAA1755

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_001025035.1	Gene:	KIAA1755 / 85449	HGNCID:	29372	Length:	1200	Species:	Homo sapiens

Alignment Length:	777	Identity:	149/777 - (19%)
Similarity:	243/777 - (31%)	Gaps:	263/777 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2545 AQSLAEELRSLNLIPGDAPEFCYS--PKTERSE------PKIPLITEKIKILSEVQP-------- 2593
            |:.|.|::|.....|.....|.:.  |...|.|      |..||:..:.....:|:|
Human    55 AKRLCEQVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCI 119

  Fly  2594 -------------KEPPPQGGVPVFPPPLGLQTVQHESTTTKEVKVEYGQPIVRPAAVLATPAQQ 2645
                         |:|.|:...|:......|:.:..:..         |.|:..     ...|.:
Human   120 MIKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFE---------GNPLHN-----CLVASE 170

  Fly  2646 NPRSPSPKPSAEGVAMSRLWTPTGVTGYTSDVEQKSEKTVISKLAT---PTPTK--ELNAPFLVN 2705
            |..:|.|            ||......:..|..|     |::.|..   |.|.:  :|::|..::
Human   171 NGIAPVP------------WTKITSPEFVDDRPQ-----VVNALCQAWGPLPLEALDLSSPQELH 218

  Fly  2706 QIAKSIPPTTAPVTHLVN-------------VELEPGTPPEICFAPKVEETRRRSLVETMEQKLE 2757
            | |.|......|...|..             :::|.....|:.|          .:.|.:.|..|
Human   219 Q-ASSPDNQVLPAQSLAKGKGRTYGSKYPGLIKVEQARCGEVAF----------RMDEVVSQDFE 272

  Fly  2758 QNLI-----------QGPS---------------------------KVLPHSV----PTL----- 2775
            .:.:           :.||                           |:||.|.    |:|
Human   273 GDYVALLGFSQESRGESPSREAGTSSGCTSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRAC 337

  Fly  2776 TPNTAAPVQPKPLG-----------NTTYRPPPPVLPTRLGVYESDYESDRYKYSGSESDVEPGI 2829
            |...::..:|..||           :.:.|||.       |.|.:..|......||    :..|:
Human   338 TKPESSEERPYNLGFRRKVNLKAPTHNSERPPQ-------GSYMNVLEDALDCASG----LRAGV 391

  Fly  2830 RKQPQLTTMETSFKSSGYTADTEEHSSYRKSESSFYETKSSSTMGGAPQLQTQFP-------KLQ 2887
            .::|..:.|:      |...:.|          :..:.:.......:|:|....|       |::
Human   392 SQEPAASKMQ------GPLGNPE----------NMVQLRPGPRQASSPRLSPASPAAAASETKIE 440

  Fly  2888 ----------PEP-PAPIYFTAKPQPQVP------------PQVPPSQSNVSSQEAKGYKYTSSS 2929
                      |:| |.|...|:.|:|..|            |.|.|.::  |.|....:|.
Human   441 VKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKA--SLQHNGPWKV---- 499

  Fly  2930 MTSNYSHNMQSSSSSSHHETKFSSTSAPPPVVTYPSPIPAQRKTPAAEFSDYSSEIDERFRSVSR 2994
            :.|.||.....:.|.....|..:.||.|   .|.|||: .:.|....|.|..|.|         |
Human   500 LCSLYSPKPNRAKSLGKAGTTQTKTSGP---ATAPSPL-TEEKAALPEASAGSPE---------R 551

  Fly  2995 ANESDAEIKGYRVVFPPTPTPRTNIATNGHKSPVVVITPSPMEFEPTPQDYA-RPKFEPISKEIR 3058
            ....:.|        ||.|.||  |...|     |.:..|.:...|..:|.| ||.....:.|..
Human   552 GPTLEEE--------PPGPEPR--IGALG-----VKVFRSRIACLPGGRDRAGRPLLLVSTTEGA 601

  Fly  3059 HEIKTETSSKQSKFMQNQQQNQPVFKPKPV-AAKFIAATQQQQQKQPQATSRPTMYYNAVAGAPM 3122
            .|....|.|:.:|.:     :.....|:|. .||.:|.....:::.||.        ..|:....
Human   602 WEAPWCTVSEVTKLL-----SYLCTIPRPEDKAKGLAVLIDARRQPPQP--------GLVSALQA 653

  Fly  3123 HVAKVATETKNVMQMHESTESSQ-------RVVNMQQTKRIIHFDSPQEQRDQQILE-PFPY 3176
            ..|:|....:.::.:.|...:.|       :|..:...|.:.|...|.:.  ..:|| ||||
Human   654 TQAQVPASIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQL--PAVLEGPFPY 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259
		RILP-like	<1190..1315	CDD:304877
		MAP7	1233..1365	CDD:283355
		I-set	1390..1479	CDD:254352
		IGc2	1403..1469	CDD:197706
		I-set	1491..1580	CDD:254352
		IGc2	1504..1570	CDD:197706
		I-set	1589..1675	CDD:254352
		Ig	1605..1675	CDD:299845
		I-set	1702..1786	CDD:254352
		Ig	1713..1786	CDD:299845
		I-set	1811..1902	CDD:254352
		Ig	1828..1892	CDD:143165
		I-set	1927..2015	CDD:254352
		IGc2	1940..2005	CDD:197706
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
KIAA1755	NP_001025035.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..302		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..372		10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..491		19/116 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..568		22/80 (28%)
		CCDC154	675..1043	CDD:317803	11/41 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1056..1200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900