DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and AIP5

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_116671.1	Gene:	AIP5 / 850570	SGDID:	S000001912	Length:	1233	Species:	Saccharomyces cerevisiae

Alignment Length:	1472	Identity:	288/1472 - (19%)
Similarity:	524/1472 - (35%)	Gaps:	435/1472 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 ANELSSQ--LDNLQRQLQQTPDEHKLQFLQATWTGIASTFGELKSRGQRFINLKIVDPYLETKSS 717
            |.|||||  ...|:...::...:.|....:.|...::|:.||.:....|    ..:...||.|..
Yeast    64 AQELSSQRKSSKLKGHKKKNQGQIKANRDRDTIVKLSSSVGETEEASTR----DAISHDLERKDD 124

  Fly   718 A-QAVQETLNDFSKR----QVDVTSSL-ENWTTSIAEKREVEYLLEKVMSDNEETVAKSTQVDTQ 776
            . :...:|:||.::.    .:||...: |..|.::||..|           |...:.:||.::..
Yeast   125 VIEIATDTINDATESPTQIPIDVNVVIKETSTNNVAEGTE-----------NVPPIKESTGIEVG 178

  Fly   777 LYPVFTSQSVDSKQLLISTREKLTNVIQDIERAQDEIQQRIQTTL-----GIQTKDQPSLAKIEQ 836
            ..|: |.:..:.|:...:.|.:      :.....|......|:||     ||:...|...:|.|.
Yeast   179 NSPI-TRRKKNKKKKTTNRRGR------NSSNPADTTDLSKQSTLDSILVGIEEYLQEDGSKNED 236

  Fly   837 VINNLRMLKAKLDGIKYDYRTLVESVIQFLENIVQLRREIDDYFARQQKEPASGADRSI----AE 897
            :..|: :....::..|.|.||..||..:..:..|..:..:|        |.:|.::.:|    ||
Yeast   237 IKVNI-VQDEPVNVEKMDIRTRNESSDKTFDIDVPNKDNVD--------ETSSKSENNINEEKAE 292

  Fly   898 HEKFRDQCMDKFRSLITQSELL-------IDRVRVLEPPG-----------AREIDTDRILKLLE 944
            |...|:           ::|:|       ......|||.|           .::::::.:.|
Yeast   293 HTLPRE-----------ENEILNVNEGNAASFKHQLEPHGLEAGDENGQASTKDVESESLTK--- 343

  Fly   945 NLRLHFESNSSARMSTLERLEKIEQFRSDLEDIDRSLDSVSQQLHEINNQSVDSLAAAKTTSLAF 1009
             ...:|:.|.|..:...|:    :|..||.:.|..|:.:.:|:..||..:           ...|
Yeast   344 -NGFNFKENESKHLKAGEK----QQTESDRDGISPSVLAKNQKETEIGKE-----------DHVF 392

  Fly  1010 EYFERTIE-CSMPRQLKSTRHQRRWGQTAHTIELLEKRIEKFTESTSQQLFITNPESERYVKDEL 1073
            |..::..| |   |:..|..|:....             ..|..:.|..  |..||:||...|:
Yeast   393 EQKDKEDEKC---RKELSVNHENNMS-------------HNFNAAGSDS--IIPPETERETYDD- 438

  Fly  1074 RKLNEKWQSFKDQVKQKRKSLNQATDFFEV-VEKIDAEYREISYFYTSVSNKVPYLRDSVEA--G 1135
                |.....| ::....|:|...|:...| |||.:.|..|.....|....|...:....||  .
Yeast   439 ----ETMGPTK-RISDNEKNLQHGTNDISVEVEKEEEEEEEEEENSTFSKVKKENVTGEQEAVRN 498

  Fly  1136 NLVNDIENYVTSREAALRSKLDSASQCAHDMNKVSSLYNDVMNIFQSFIKLKMDINVVQERLKQE 1200
            |.|:..|...||:...:....:..|: |.:.:.:..:....     :..|:..|..|:::..:..
Yeast   499 NEVSGTEEESTSKGEEIMGGDEKQSE-AGEKSSIIEIEGSA-----NSAKISKDNLVLEDEAEAP 557

  Fly  1201 QRQKEQRE-------RDA-RDQAEREKAIKEAEAKERLHREEQSRLENQRQQAAIEQAQRELAAR 1257
            .::.:..|       .|| ||..|..:|:::....|.|   |.::.:.:.:|..:::..:.:...
Yeast   558 TQENKPTEVVGEIDIPDAPRDDVEIVEAVEKNIIPEDL---EVAKEDQEGEQVKLDEPVKAMKDD 619

  Fly  1258 ELALR------EQAVREEEARLQAIREQATRE--QLAREQA----------------------AR 1292
            ::|:|      |...:::|...:...|:|.:|  :.|||.|                      .|
Yeast   620 KIAMRGAESISEDMKKKQEGTAELSNEKAKKEVDETARESAEGVEVEKSKTPESPKVVKRCTSGR 684

  Fly  1293 EEELRIQSLRDIARREEEVRLQNIRDEETRIRREEEERIRRENESRSKREEEARIQREEITRLQT 1357
            .|:|:|.      .|:.||..:::|..:..::.|....|  ||    ..||:.:.||.:|:
Yeast   685 PEDLQIN------ERDPEVLKEDVRVPDEDVKPEIATTI--EN----SEEEDPKSQRVQIS---- 733

  Fly  1358 LRDQVDQQRIVTENIRKDIQVNSIFTELRYASPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVE 1422
                 .:|...|:....|:...:.|.|..       :|.:..:::|||:      :||
Yeast   734 -----TEQAETTQKDMGDVGSTTSFKEEE-------KPKRFEITQEGDK------ITG------- 773

  Fly  1423 WFKDGISIQTNSDYKTTFDKGICRLVIEETFAADSARFSCRASNLVGTC-------------DTN 1474
              ||     ||.::..               |.::|..:.:||: |||.             ||.
Yeast   774 --KD-----TNHEHGE---------------ATEAASENSKASD-VGTAEKYIEPSSESVKKDTE 815

  Fly  1475 ATLSVRENAAEVQLVPPRI-LRFLQSGKATEGSSFQFACVVAGVPLPTVQWFKNDKCIDDSPDYV 1538
            ....| ||:.:.:.:..:. |..|.:.|..|               .|.:..|.::.:
Yeast   816 EDAEV-ENSEKTEFIKVKAELENLDAPKEAE---------------VTAELNKENEDV------- 857

  Fly  1539 ISYNNGEATLKFEEVFLEDDAVYTCSASNPAGIEHCSASLIVEPLEPTELPSFKVPLSNAMARVG 1603
                         ||..|:||.                   ||..|.||....|..|.|..|...
Yeast   858 -------------EVDTEEDAE-------------------VENSEKTEFIKVKAELGNLDAPKE 890

  Fly  1604 QKIKLE-------AIVGGIPRPEVYWLHNGKPFQPRDSKYEYGRVTLIIPQAYPNDAGSYVLSAK 1661
            .::..|       ..|....:.::    ..|..:|.::..|.|  |....:....||.:.....:
Yeast   891 AEVTAELNKENEDVEVAATSKEDI----ETKCSEPAETPIEDG--TCTEAEVSKKDAEAVTKEDE 949

  Fly  1662 NLAGEAYTSCNVIVKGRLPNETSDSEMASDI---EPIKPAVHLP---LKDVSIFEGKPVRLDCVI 1720
            |:.       |..:...|.:.|.|.|: .||   :..:..|.||   .:|:...:|:...|:
Yeast   950 NME-------NSKIAEALKDVTGDQEI-DDINISDEFQRTVELPELEKQDIKDNKGEDKELE--- 1003

  Fly  1721 VGQPE-----PEVIWYHN----ERPVKESADVQLLFQGDRCSLIIQEVYQEDAGHYKVVAINSAG 1776
            |.:.|     |:::...|    :..:|:..               :||.|.|....:.::
Yeast  1004 VEETEKETSLPDLVVEENITEEKNEIKQEE---------------EEVSQLDFNETESIS----- 1048

  Fly  1777 EASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFERLLSDVLADEGEQVVLEVQASGDQPLT 1841
                    |..| |..|.....|:.|::..|.|.   :.:..|:| ||..:.:.:::...|..|
Yeast  1049 --------KEAP-NNDENGFEDQSTRENPKKASA---DDIFKDIL-DETNEFLEQLKIVDDSEL- 1099

  Fly  1842 AQWFLTNKELQ-LDQRITTQSDSELGVFKLILNNVSGDD-------------KGVYTVKVTNPAG 1892
                  |..|| ||.:.:|...:|    :...||....|             :.||.  .|:.||
Yeast  1100 ------NALLQSLDAKDSTTQTTE----QSKKNNDKPQDVITTSEIRKLNEKEPVYI--YTSLAG 1152

  Fly  1893 DAKCFSHLIVKSVNAPENRRSSQSSVEIIERHQCP-EFKELFSDKQGEIDEVIK-FECIVKGKPT 1955
            ..   .|:|.::     ||.|:     |:..::.| .:::|.:|     ||..| ::...||:..
Yeast  1153 GG---FHMIPRT-----NRLST-----ILTANRIPFTYRDLGTD-----DEARKVWKTFSKGRSL 1199

  Fly  1956 PKVHWFFNDQPVHGHNFLVSTSGE----RQVLTIQKLTHDAV 1993
            |.|        |.|||.|:....|    .:...:::|.:|.:
Yeast  1200 PGV--------VRGHNDLIGNWEEIEEANEDYKLRELIYDTI 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259	74/379 (20%)
		RILP-like	<1190..1315	CDD:304877	30/162 (19%)
		MAP7	1233..1365	CDD:283355	30/161 (19%)
		I-set	1390..1479	CDD:254352	19/101 (19%)
		IGc2	1403..1469	CDD:197706	13/65 (20%)
		I-set	1491..1580	CDD:254352	11/89 (12%)
		IGc2	1504..1570	CDD:197706	8/65 (12%)
		I-set	1589..1675	CDD:254352	15/92 (16%)
		Ig	1605..1675	CDD:299845	11/76 (14%)
		I-set	1702..1786	CDD:254352	13/95 (14%)
		Ig	1713..1786	CDD:299845	10/81 (12%)
		I-set	1811..1902	CDD:254352	22/104 (21%)
		Ig	1828..1892	CDD:143165	15/77 (19%)
		I-set	1927..2015	CDD:254352	18/73 (25%)
		IGc2	1940..2005	CDD:197706	15/59 (25%)
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
AIP5	NP_116671.1	2A1904	<271..>528	CDD:273344	64/319 (20%)
AIP5	NP_116671.1	PTZ00121	<482..1082	CDD:173412	141/777 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900