DRSC/TRiP Functional Genomics Resources

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Protein Alignment zormin and Kalrn

DIOPT Version :9

Sequence 1:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster
Sequence 2:XP_038944566.1 Gene:Kalrn / 84009 RGDID:621865 Length:2989 Species:Rattus norvegicus


Alignment Length:2438 Identity:447/2438 - (18%)
Similarity:782/2438 - (32%) Gaps:871/2438 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 IQLVIALLQSPEKIYIKVVELEPKITALGENLDESLRMQREHDETLRNLQSLPGPMDEFVQKADK 171
            :|.|:..:::..:.::.      |.|.:|::|..:..:|:.||:.....|:.....|:.::.|::
  Rat   548 VQQVLDWIENHGEAFLS------KHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQ 606

  Fly   172 LLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILCTQFHDKMTQCFRKMDQLELACEETL 236
            |..:.....|.:...|..|.:..||.:..::.|:.||.:...||....:.:..|:.|:....|.:
  Rat   607 LAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEVLEDV 671

  Fly   237 HPPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQL------------------------- 276
            ....|..|||.:.:|:|.:...|...:..:|:|.:|:.||                         
  Rat   672 CADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPTEARDSAVSNNKTPH 736

  Fly   277 ---------------------EEL----------------------EKLETLDTRPEHIKR---- 294
                                 |||                      |....||...|.:.|    
  Rat   737 SSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND 801

  Fly   295 ----DATRA---------------------------VH-----------------------QVQQ 305
                |.|.|                           :|                       |||:
  Rat   802 FNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGIELICEKDVDLAAQVQE 866

  Fly   306 WLEALHDRRNSLEL-AWQTRKIQMEQCLALALLGRELVDLEAALQQARMELNTMY----SLGECE 365
            .||.||::::.||| |.||.| ::||||.|..|..|:..:...::.....||...    ||.|.|
  Rat   867 LLEFLHEKQHELELNAEQTHK-RLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAE 930

  Fly   366 HTANEMLTKYREWKQQALLL------------RDRALKITRAKEKVQSAGHFTEEDACARAYAVL 418
            ..       .||.:|..|.:            ...||::.:..|.:..|||:   ||.|     :
  Rat   931 QL-------QREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEALLQAGHY---DADA-----I 980

  Fly   419 SGCTEHLDLVDQREHW-------------LHQSREFFAKAEHTVSVLEKLELELT--------SV 462
            ..|.|.:.|     ||             ::.|..|:..:|...||||.||.|..        ..
  Rat   981 RECAEKVAL-----HWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRD 1040

  Fly   463 KLPPHSPESYA--MFSK--------------VDRDVRNFTEEPLRLGYGILDEVGRTQPETQGVK 511
            ||.|.:...:.  :.||              ..|:...|.:...|....:......|:...|.||
  Rat  1041 KLGPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVK 1105

  Fly   512 RVLDEL---ENRKVYIQGICANSSED-QQKVQRALSEFLNHHNELLAWLRASGQHQLQQSVDMGG 572
            .:|.||   |||.::...:.....:. ||.|     .|.....:.|.|::.:|::.|......|.
  Rat  1106 AILSELLQRENRVLHFWTLKKRRLDQCQQYV-----VFERSAKQALDWIQETGEYYLSTHTSTGE 1165

  Fly   573 NLQQAKQFLLQHHELMQDLEIKGELINLLLESIKVHLESLSPQERYDVDSKAESLHKH------W 631
            ..::.::.|.::.|.....:...|.:.||::.               .||..|..|.|      |
  Rat  1166 TTEETQELLKEYGEFRVPAKQTKEKVKLLIQL---------------ADSFVEKGHIHATEIRKW 1215

  Fly   632 I-----ELKDLVLKRVDYVSLLIDFFELANELSSQLDNLQRQLQQTP---DEHKLQFLQATWTGI 688
            :     ..:|..|:...|...|    |.|..:::: ||...:|...|   .:.:::...|.    
  Rat  1216 VTTVDKHYRDFSLRMGKYRYTL----EKALGVNTE-DNKDLELDIIPASLSDREVKLRDAN---- 1271

  Fly   689 ASTFGELK---SRGQRFINLKIVDPYLET-KSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEK 749
             ....|.|   :|.:.||..::    |:| |:..:.:.|.|..:   ..::||.:|.....|..|
  Rat  1272 -HEVNEEKRKSARKKEFIMAEL----LQTEKAYVRDLHECLETY---LWEMTSGVEEIPPGILNK 1328

  Fly   750 REVEY-LLEKVMSDNEETVAKS----------------TQVDT-QLYPVFTSQSVDSKQLL---- 792
            ..:.: .::::...:.....|.                |..|. |:|..:.....||.||:    
  Rat  1329 EHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHA 1393

  Fly   793 ------ISTREKLTNVIQD----------------------IERAQDEIQQRIQTTLGIQTKDQP 829
                  |..|..|.|.|..                      .|..:.|::..::..|.:..|...
  Rat  1394 GTFFDEIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKAND 1458

  Fly   830 SLAKIEQVINNLRMLKAKLDGIKYDYRTLVESVIQFLENIVQLRR---------EIDDYFARQQK 885
            ::        ::.||:...:.:......:::...|..:....:|:         ||...|:::.|
  Rat  1459 AM--------HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIK 1515

  Fly   886 EPASG------------ADRSIAEHEKFRDQCMDKFRSLITQSELLIDRVRVLEP---------- 928
            : :||            ::..:.||.: .|.|.....|..|.|.   |...||:.          
  Rat  1516 D-SSGHTKYVYKNKLLTSELGVTEHVE-GDPCKFALWSGRTPSS---DNKTVLKASNIETKQEWI 1575

  Fly   929 PGAREIDTDRILKLLENLRLHFE-SNSSARMSTLERLEKIEQFRSDLEDIDRSLDSVSQQLHEIN 992
            ...||:..:||:.|...|:...: ..:.|::....:       |..:||.|...|..||.     
  Rat  1576 KNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSK-------RDGVEDGDSQGDGSSQP----- 1628

  Fly   993 NQSVDSLAAAKTTSLAFEYFERTIE-------CSMPRQLK--STRHQRRWG-QTAHTIELLEKRI 1047
                |:::.|..||      :.|:|       |.:...|:  |..|..... |...|:||||:..
  Rat  1629 ----DTISIASRTS------QNTVESDKLSGGCELTVVLQDFSAAHSSELSIQVGQTVELLERPS 1683

  Fly  1048 EK----FTESTSQQLFITNPESERYVKDELRKLNEKWQSFKDQVKQKRKSLNQATDFFEVVEKID 1108
            |:    ...:|.:     :|..|..|......::..            :|..:...||.:|:.  
  Rat  1684 ERPGWCLVRTTER-----SPPQEGLVPSSTLCISHS------------RSSVEMDCFFPLVKD-- 1729

  Fly  1109 AEYREISYFYTSVSN-----KVPYLRDSVEAGNL---------VNDIENYVTSREAALRSKLDSA 1159
                  ||.::|..|     .|..|:......::         .|.::.::||....|.|.    
  Rat  1730 ------SYSHSSGENGGKSESVANLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSG---- 1784

  Fly  1160 SQCAHDMNKVSSLYNDVMNIFQSFIKLKMDINVVQERLKQEQRQKEQRERDAR------------ 1212
                                       |.|.|:          :|:::.||.|            
  Rat  1785 ---------------------------KADGNI----------KKQKKVRDGRKSFDLGSPKPGD 1812

  Fly  1213 ------DQAEREKAIK---EAEAKERLH---------------REEQSRLENQRQ-------QAA 1246
                  |.|: ||:.|   |.|..|..|               ::|.|.|...||       .|.
  Rat  1813 ETTPQGDSAD-EKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQAPTDVPTAAD 1876

  Fly  1247 IEQAQRELAARELALREQAVR-----------------------EEEARLQAIR-EQATREQLAR 1287
            :..|..:|...:|.|...:.|                       |||.:.:|:| ......:|.:
  Rat  1877 LVSAIEKLVKSKLTLEGGSYRGSLKDPTVCLNEGMAPPTPPRNLEEEQKAKALRGRMFVLNELVQ 1941

  Fly  1288 EQAAREEELRI-----------QSLRDIARREEEVRLQNIRD----------EETRIRREEEERI 1331
            .:....::|.|           :.:.:..|.:|::...||..          .|.....:|::|:
  Rat  1942 TEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRL 2006

  Fly  1332 RR----------------ENESRSKREEEARIQREEITRLQTLRDQVDQQRIVTENIRKDIQVNS 1380
            .:                :|:.||:     .|..|.....:.::.:::|:..:::.:.|.||..:
  Rat  2007 AQLFIKHERKLHIYVWYCQNKPRSE-----YIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRIT 2066

  Fly  1381 IFTELRYASPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWF--------------------- 1424
            .:..|          |||.: |..::...||   ...|.|||..                     
  Rat  2067 KYQLL----------LKDFL-RYSEKAGLEC---SDIEKAVELMCLVPKRCNDMMNLGRLQGFEG 2117

  Fly  1425 ---KDGISIQTNSDYKTTFDKGICR---------------------------------------L 1447
               ..|..:|.::.|....|.|:..                                       |
  Rat  2118 TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYL 2182

  Fly  1448 VIEETFAADSARFS-----------CRASN----LVGTCDTNATLSVR----------------- 1480
            |:||....|..:|:           .:|:|    .....|.|..|..:                 
  Rat  2183 VLEEDVDDDPCKFALMNRETSERVILQAANPDIQQAWVQDINQVLETQRDFLNALQSPIEYQRKE 2247

  Fly  1481 ENAAEVQLVPPRILRF---------LQSGKATEGSSFQFACVVAGVPLPTVQWFKN--------- 1527
            .:.|.::..|||:.:.         :.|.|..:|||:       ..|||.::...:         
  Rat  2248 RSTAVIRSQPPRVPQASPRPYSSVPVGSEKPPKGSSY-------NPPLPPLKISTSNGSPGFDYH 2305

  Fly  1528 ---DKCIDDSPDYVISYNNGEAT---------LKFEEVFLEDDAVY---------TCSASNPAGI 1571
               || .|.|....:...||.:|         ||..|:.:....|.         .|....||. 
  Rat  2306 QPGDK-FDASKQNDLGGCNGTSTMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPAS- 2368

  Fly  1572 EHCSAS------LIVEPLEPTELP------SFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLH 1624
            :|..|:      .|:.||.....|      |.|...|....|:.::..:|              :
  Rat  2369 DHSPAAEGWVPGSILAPLTKATAPAESSDESIKKSCSWHTLRMRKRADVE--------------N 2419

  Fly  1625 NGK-----PFQPRDSKYEYGRVTLIIPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVKGRLPNETS 1684
            .||     |.:|:|              ...|.|     |.|.......:.|:.:.    ||.:.
  Rat  2420 TGKNEATGPRKPKD--------------ILGNKA-----SVKETNSSEESECDDLD----PNTSM 2461

  Fly  1685 DSEMASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLLFQG 1749
            :....:.|:.:.|...:||.||:...|..|.|.|...|:|:|.:.|...::.:.::.:....:..
  Rat  2462 EILNPNFIQEVAPEFLVPLVDVTCLLGDTVLLQCKACGRPKPTITWKGPDQNILDTDNSSATYTI 2526

  Fly  1750 DRC-----SLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDS 1809
            ..|     :|.|..:..:|:|.|..:|.|..|.||:|..:||    |..||...:...|      
  Rat  2527 SSCDSGESTLKICNLMPQDSGIYTCIATNDHGTASTSATVKV----QGVPAAPNRPIAQ------ 2581

  Fly  1810 QPKFERLLSDVL------ADEGEQVV----LEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSE 1864
                ||..:.|:      |..|...:    :|.:..|.|    .|         .|.:.:..|: 
  Rat  2582 ----ERSCTSVILRWLPPASTGNCTISGYTVEYREEGSQ----VW---------QQSVASTLDT- 2628

  Fly  1865 LGVFKLILNNVSGDDKGVYTVKVTNPAG-----DAKCFSHLIVKSVNAPENRRSSQSSVEIIERH 1924
                .|::.::|......:.|..:||.|     :...|.||       ||...::..:.      
  Rat  2629 ----YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVHL-------PEYDAAADGAT------ 2676

  Fly  1925 QCPEFKELFSDKQGEIDEV------IKFECIVK 1951
              ..:||.|.....|::|:      |..:||.|
  Rat  2677 --ISWKENFDSAYTELNEIGRGRFSIVKKCIHK 2707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zorminNP_001261317.1 SPEC 126..332 CDD:238103 64/332 (19%)
SPEC <504..641 CDD:295325 31/151 (21%)
COG1340 960..1298 CDD:224259 77/432 (18%)
RILP-like <1190..1315 CDD:304877 35/202 (17%)
MAP7 1233..1365 CDD:283355 31/199 (16%)
I-set 1390..1479 CDD:254352 26/166 (16%)
IGc2 1403..1469 CDD:197706 19/143 (13%)
I-set 1491..1580 CDD:254352 26/133 (20%)
IGc2 1504..1570 CDD:197706 19/95 (20%)
I-set 1589..1675 CDD:254352 16/96 (17%)
Ig 1605..1675 CDD:299845 11/74 (15%)
I-set 1702..1786 CDD:254352 24/88 (27%)
Ig 1713..1786 CDD:299845 19/77 (25%)
I-set 1811..1902 CDD:254352 20/105 (19%)
Ig 1828..1892 CDD:143165 11/67 (16%)
I-set 1927..2015 CDD:254352 9/31 (29%)
IGc2 1940..2005 CDD:197706 5/18 (28%)
I-set 2142..2231 CDD:254352
Ig 2158..2231 CDD:299845
I-set 2238..2325 CDD:254352
Ig 2254..2324 CDD:299845
I-set 3566..3655 CDD:254352
Ig 3583..3650 CDD:143165
KalrnXP_038944566.1 SEC14 42..180 CDD:214706
SPEC 193..413 CDD:238103
SPEC 314..539 CDD:238103
SPEC 540..769 CDD:238103 41/226 (18%)
SPEC 894..1132 CDD:238103 55/257 (21%)
SPEC 1138..1238 CDD:197544 21/118 (18%)
RhoGEF 1287..1457 CDD:238091 30/176 (17%)
PH1_Kalirin_Trio_like 1464..1586 CDD:270060 22/126 (17%)
SH3_Kalirin_1 1652..1711 CDD:212786 14/63 (22%)
SH3-RhoG_link 1708..1892 CDD:406906 40/245 (16%)
RhoGEF 1935..2104 CDD:395496 30/187 (16%)
PH2_Kalirin_Trio_p63RhoGEF 2109..2243 CDD:270061 16/133 (12%)
SH3_Kalirin_2 2327..2385 CDD:212787 11/58 (19%)
Ig strand A 2466..2469 CDD:409353 0/2 (0%)
I-set 2474..2568 CDD:400151 25/93 (27%)
Ig strand A' 2482..2485 CDD:409353 2/2 (100%)
Ig strand B 2491..2498 CDD:409353 3/6 (50%)
Ig strand C 2504..2512 CDD:409353 1/7 (14%)
Ig strand C' 2515..2517 CDD:409353 0/1 (0%)
Ig strand D 2523..2532 CDD:409353 1/8 (13%)
Ig strand E 2534..2538 CDD:409353 1/3 (33%)
Ig strand F 2547..2555 CDD:409353 3/7 (43%)
Ig strand G 2558..2568 CDD:409353 4/9 (44%)
FN3 2572..2663 CDD:238020 20/118 (17%)
STKc_Kalirin_C 2693..2940 CDD:271017 4/15 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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