DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and Palld

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_001280701.1	Gene:	Palld / 72333	MGIID:	1919583	Length:	1408	Species:	Mus musculus

Alignment Length:	1572	Identity:	305/1572 - (19%)
Similarity:	486/1572 - (30%)	Gaps:	598/1572 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1117 FYTSVSNKVPYLRDSVEAGNLVNDIENYVTSREAALRSKLDSASQCAHDMNKVSSLYNDVMNIFQ 1181
            ||.|:|:    :::..::.:....:..:::..|  :...||.|.: |.|.::... ::....|.|
Mouse    10 FYDSLSD----VQEEGKSADFFPGLSAFLSQEE--INKSLDLARR-AIDSSETED-FDSEKEISQ 66

  Fly  1182 SFIKLKMDI--NVVQERLKQEQRQKEQRERDAR---------DQAEREKAIKEAEAKER------ 1229
            .|.|..:.:  ....|..|..::...:|.:|:|         |||||   |....:|.:
Mouse    67 IFSKSPISLCETPSHEEPKSGKQTSSERPQDSRRAPVQPLTGDQAER---ITSPGSKRKPGVSPL 128

  Fly  1230 ---------LHREEQSRLENQRQQAAIEQAQRELAARELALREQAVREEEARLQAIREQATREQL 1285
                     |.:.|:...:|....:..:.||:..|..:..|.::|....|......||.|
Mouse   129 LASPSYIRSLRKAEKRGAKNPNPSSKPKTAQQSKAGPQSQLCDKAASFIEELTSIFREAA----- 188

  Fly  1286 AREQAAREEELRIQSLRDIARREEEVRLQNIRDEETRIRREEEERIRRENESRSKREEEARIQRE 1350
                                              :.|.|....|....::...|.:.:.:.:...
Mouse   189 ----------------------------------KPRNRSPNGESSSPDSGYLSPKNQPSALMSA 219

  Fly  1351 EITRLQTLRDQVDQQRIVTENIRKDIQVNSIFTELRY---------------------------A 1388
            ..::..| .||:||       :..|.:|......|.|                           .
Mouse   220 SASQSPT-ADQLDQ-------LEMDAEVKQAQGSLCYQAHQASEETLPLAHIPHPQPQKARHLPT 276

  Fly  1389 SPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFDKG-ICRLVIEET 1452
            :|.|.:.|:.....||.|...||.|||.|.|.|.||.:|..:..:.|.:...:.| :..|||.|.
Mouse   277 APRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELYNSPDVQIHCESGELHTLVIAEA 341

  Fly  1453 FAADSARFSCRASNLVGTCDTNA------------------------------------TLSVRE 1481
            |..|:.|::|.|:|..|:..|:|                                    :|::..
Mouse   342 FEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDSDSESLSFISKAGAMPQAQKKTTSVSLTIGS 406

  Fly  1482 NAAEVQL---------VP-----------------------PRILRFLQSGKATEGSSFQFACVV 1514
            :|.:..:         ||                       |...:.||:..|:||......|.|
Mouse   407 SAPKTGVTTAVIQPLSVPVQQAHSATSYLCRPDGTTMGCLLPVFTKELQNTAASEGQVVVLECRV 471

  Fly  1515 AGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEV--------FLEDDAVYTCSASNPAGI 1571
            .|.|...||||:....|.||||:.|......:|.:.||:        |.||..::||||:|..|.
Mouse   472 RGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAESFPEDAGIFTCSATNDYGS 536

  Fly  1572 --------------EHCSASLIVEP--------------LE----------PTELPSFKVP-LSN 1597
                          |:||.....||              ||          |:|:.....| |..
Mouse   537 VTSTAQLVITSANNENCSYDSTGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQVNSPNLGF 601

  Fly  1598 AMARVGQKIK-LEAIVGGI-PRPEVYWLHNGK--------------------------------- 1627
            :||.:..:.. .|....|: |...|..|.|||
Mouse   602 SMAALQMQFNTAERETNGVHPSHGVNGLINGKAYGNKSPPTPTALLSPTKEPPPLLAKPKLDPLK 666

  Fly  1628 ---------------------------------------PFQPRDSKYEYGRVTLIIPQAYP--- 1650
                                                   ||.|.             |.|:|
Mouse   667 LQQLQNQVRLEQEACAWPPAPPGVPCNSSSSGSSAPPSPPFPPP-------------PPAFPELA 718

  Fly  1651 ---------------------NDAGSY-------VLSAKNLAGEAYTSCNVIVKGRLPNETSDSE 1687
                                 ..:||:       .::|:|| |.|         ..||..||...
Mouse   719 ACASPVPSEPMSALASRATAMQSSGSFNYARPKQFIAAQNL-GPA---------SGLPTPTSSPS 773

  Fly  1688 MASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQP--EPEVIWYHNE-------RPVKESADV 1743
            .:|...|:.|... |      |...|        |.|  |||.:|..:.       .||...:
Mouse   774 SSSLPSPLSPTPR-P------FGRAP--------GPPFVEPEAMWGPSSPSPPPPPPPVFSPS-- 821

  Fly  1744 QLLFQGDRCSLIIQEVY-------------------------QEDAGHYKV--------VAINSA 1775
                    .:..:.:|:                         |..|.....        ||:|:.
Mouse   822 --------AAYPVPDVFPLPPPPPPLPSSTSHCASPARFGPSQTPAAFLSALLPSQPPPVAVNAL 878

  Fly  1776 GEASSSCELKVTPLNQAEPATRA---------QAERQSLPKDSQPKFERLLSDVLADEGEQVVLE 1831
            |....     |||....:.::|.         |..:.::.:|.:.|. |...|:|
Mouse   879 GLPKG-----VTPAGFPKKSSRTARIASDEEIQGTKDAVIQDLERKL-RFKEDLL---------- 927

  Fly  1832 VQASGDQPLTAQWFLTNKELQLDQR--ITTQSDSELGVFKLILNNVSGDDKGVYTVKVTNPAGDA 1894
              .:|...||.:..:..:.|..|..  ...|...|         ..:..|.|.....|..|....
Mouse   928 --NNGQPRLTYEERMARRLLGADSANVFNIQEPEE---------TAANQDAGAPRASVGGPLDGQ 981

  Fly  1895 K------CFSHLIVKSVNAPENRRSSQSSVEI------IERHQCPEFKELFSDKQGEIDE--VIK 1945
            |      |...||.:.....|.....:|..|:      :|....|.|:  ...|..:|.|  .:.
Mouse   982 KEYKVSSCEQRLISEIEYRLERSPVDESGDEVQDPDVPVENATAPFFE--MKLKHYKIFEGMPVT 1044

  Fly  1946 FECIVKGKPTPKVHWFFNDQPVHGHNFLVSTSGERQVLTIQK------------LTHDAVGKISC 1998
            |.|.|.|.|.||::||.:.:.:         |.:....|||:            .|.|..|..:.
Mouse  1045 FTCRVAGNPKPKIYWFKDGKQI---------SPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTI 1100

  Fly  1999 VAENEAGKATCVAFLNIRGSGLPASSDVQTVSQEHNTESSRVTIKKQTFTTTSTSQVNSYEGNAP 2063
            :|.|..|:.:|...|.           ||.|:|                           .|.:|
Mouse  1101 MAANPQGRVSCTGRLM-----------VQAVNQ---------------------------RGRSP 1127

  Fly  2064 QTEVHHSSAHIDQSLKQLGQQRPEIVESHHYQELHKSKEMSSPTVQQKSF--SFIQSSGANGQSA 2126
            ::...|..|           :||.       .....|.:.:.| :|::.|  .|:|
Mouse  1128 RSPSGHPHA-----------RRPR-------SRSRDSGDENEP-IQERFFRPHFLQ--------- 1164

  Fly  2127 VAIPDSPTRLRREIAPRFTTPLSGKIVDQGADVSMEAIYDGFPSPEIKVEKNGGQLFED-AHTRI 2190
                          ||...|...||:......||      |.|:|::..:.:|..:..| ||..:
Mouse  1165 --------------APGDLTVQEGKLCRMDCKVS------GLPTPDLSWQLDGKPIRPDSAHKML 1209

  Fly  2191 SNKCNRVTIELKQVGVGDAGRYAVTASNTVGQSTSTADLVV--KKTIFPPVFGRRLQAQVSKKGE 2253
            ..:....::.::.|...|||.|...|:|..||::...:|||  |:....|||..:||......|.
Mouse  1210 VRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFMEKLQNTGVADGY 1274

  Fly  2254 KLTMEVEVTGLPEPTVTWLKDDKPLKDA--GISEHRLLAQGNSY-RLIIEKAQTTDSGKYMVRAT 2315
            .:.:|..|:|:|.|.:.|.|:::.|..:  .:|.|:   ..:.| .|:|:.|...|:|.|.|.|.
Mouse  1275 PVRLECRVSGVPPPQIFWKKENESLTHSTERVSMHQ---DNHGYICLLIQGATKEDAGWYTVSAK 1336

  Fly  2316 NAGGEAKSIADC 2327
            |..|    |..|
Mouse  1337 NEAG----IVSC 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259	38/206 (18%)
		RILP-like	<1190..1315	CDD:304877	24/150 (16%)
		MAP7	1233..1365	CDD:283355	19/131 (15%)
		I-set	1390..1479	CDD:254352	33/125 (26%)
		IGc2	1403..1469	CDD:197706	26/66 (39%)
		I-set	1491..1580	CDD:254352	35/110 (32%)
		IGc2	1504..1570	CDD:197706	27/73 (37%)
		I-set	1589..1675	CDD:254352	25/191 (13%)
		Ig	1605..1675	CDD:299845	21/174 (12%)
		I-set	1702..1786	CDD:254352	18/125 (14%)
		Ig	1713..1786	CDD:299845	16/114 (14%)
		I-set	1811..1902	CDD:254352	18/98 (18%)
		Ig	1828..1892	CDD:143165	11/65 (17%)
		I-set	1927..2015	CDD:254352	26/101 (26%)
		IGc2	1940..2005	CDD:197706	20/78 (26%)
		I-set	2142..2231	CDD:254352	23/89 (26%)
		Ig	2158..2231	CDD:299845	19/73 (26%)
		I-set	2238..2325	CDD:254352	27/89 (30%)
		Ig	2254..2324	CDD:299845	21/72 (29%)
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Palld	NP_001280701.1	I-set	278..368	CDD:369462	32/89 (36%)
		I-set	448..545	CDD:369462	32/96 (33%)
		I-set	1026..1117	CDD:369462	26/112 (23%)
		I-set	1160..1250	CDD:369462	26/118 (22%)
		Ig_Palladin_C	1276..1350	CDD:143301	23/76 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000