DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and TRIO

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_009049.2	Gene:	TRIO / 7204	HGNCID:	12303	Length:	3097	Species:	Homo sapiens

Alignment Length:	2792	Identity:	521/2792 - (18%)
Similarity:	899/2792 - (32%)	Gaps:	905/2792 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 FHDKMTQCFRKMDQLE-----LACEETLHPPDVPRVQEFLNRFKQLRIDMLTGVMAALK-DGNEL 272
            |.|.::.....:.:||     ||.:|.  |.|:...:..:....||:..::...:..|. :|.:|
Human   220 FEDYISNATHMLSRLEELQDILAKKEL--PQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKL 282

  Fly   273 LAQLEELEKLETLDTRPEHIKRDATRAVHQVQQWLEALHDRRNSLELAWQTRKIQMEQCLALALL 337
            |.:::..|.....::...:  .|....:.:|...|:.||..|..|...|..||::::||..|.|.
Human   283 LQRIQSSESFPKKNSGSGN--ADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLF 345

  Fly   338 GRELVDL-EAALQQARMELNTMYSLGECEHTANEMLTKYREWKQQALLLRDRALKITRAKEKVQS 401
            .::...: :.......:.||:...:|.....|.|:.|::..:....:.:.....:|.....::..
Human   346 EQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVE 410

  Fly   402 AGHFTEEDACARAYAVLSGCTEHLDLVDQREHWLHQSREFFAKAEHTVSVLEKLELELTSVKLPP 466
            :||:..:.....|..:..........:|:|...|..|..|..|||..:|.::........|.||.
Human   411 SGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPS 475

  Fly   467 ----------HSPESY----AMFSKVDRDVRNFTEEPLR-LGYGILDEVGRTQPETQGVKRVLD- 515
                      |....|    ..:|:|.:|.::..::..| |..|..|.:..:...::.|..|||
Human   476 ELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV 540

  Fly   516 ---------ELEN----RKVYIQGICANSSEDQQKVQRALSEFLNHHNELLAWLRASGQHQLQQS 567
                     :|||    |||.:          .|::|  |..|.....::|.|:...|:..|.:.
Human   541 IHEVLHHQRQLENIWQHRKVRL----------HQRLQ--LCVFQQDVQQVLDWIENHGEAFLSKH 593

  Fly   568 VDMGGNLQQAKQFLLQHHELMQDLEIKGELINLLLESIKVHLESLSPQERYDVDSKAESLHKHWI 632
            ..:|.:|.:|:....:|.:..:..:......:.|||:    .|.|:.....|.:...::.|:...
Human   594 TGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA----AEQLAQTGECDPEEIYQAAHQLED 654

  Fly   633 ELKDLVLKRVDYVSLLID----FFELANELSSQLDNLQRQLQQTPDEHKLQFLQATWTGIASTFG 693
            .::|.| :||:...:|:|    |.....||.:.|:.||::|
Human   655 RIQDFV-RRVEQRKILLDMSVSFHTHVKELWTWLEELQKEL------------------------ 694

  Fly   694 ELKSRGQRFINLKIVDPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEKRE-VEYLLE 757
                         :.|.|.|   |.:|||:.:..|.::|   .::|:.....|.|..: ::.|.:
Human   695 -------------LDDVYAE---SVEAVQDLIKRFGQQQ---QTTLQVTVNVIKEGEDLIQQLRD 740

  Fly   758 KVMSDNE----------ETVAKS-TQVDTQLYPVFTSQSVDSK---QLLISTREKLTNVIQDIER 808
            ..:|.|:          |||.:. .:..:|:..:|..:.:..:   ||.|..|:.: ::|.|:|.
Human   741 SAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAI-DIISDLES 804

  Fly   809 AQDEIQQRIQTTLGIQTKDQPSLAKIEQ----------VINNLR--MLKAKLDGIKY-------- 853
            ..||:.|::.   ...|:|   |...||          .:|||.  ::....|.::|
Human   805 WNDELSQQMN---DFDTED---LTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASG 863

  Fly   854 ---------DYRTLVESVIQF------------------LENIVQLR------REIDDYFARQQK 885
                     |..|.|:.:::|                  ||..||||      :::..:....:.
Human   864 VELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNGES 928

  Fly   886 EPASG---------ADRSIAEHEKFRD----------QCMDKFRSLITQSELLIDRVRVLEPPGA 931
            ...:|         |::...|||:|:.          |...|..:::..:...:|.:|    ..|
Human   929 MLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIR----DCA 989

  Fly   932 REIDT---DRILKLLENLRL-----HFESNSSARMSTLERLEKIEQFRSDL----------EDID 978
            .::.:   ..:||:.:.|:|     .|...|....|.||.||:..:...|.          .:.|
Human   990 EKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETD 1054

  Fly   979 RSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTIECSMP----------RQLKSTRHQ--R 1031
            .....:|:.|.:..........|.:...:..:|..|. ..:||          :|:|:..::  :
Human  1055 HVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRN-SVNMPGMVTHIKAPEQQVKNILNELFQ 1118

  Fly  1032 RWGQTAHTIELLEKRIEK------FTESTSQQLFITNPESERYVK------------DELRKLNE 1078
            |..:..|...:.::|:::      |..|..|.|...:...|.|:.            .||.|.:|
Human  1119 RENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHE 1183

  Fly  1079 KWQSFKDQVKQKRKSLNQATDFFEVVEKIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDIEN 1143
            ::|....|.|::.|.|.|..|.|  .||..|...||....|:|..:  |...|:.       :|.
Human  1184 EFQITAKQTKERVKLLIQLADGF--CEKGHAHAAEIKKCVTAVDKR--YRDFSLR-------MEK 1237

  Fly  1144 YVTSREAALRSKLDSASQCAHDMNKVS-SLYNDVM--NIFQSFIKLKMDINVVQERLKQEQRQKE 1205
            |.||.|.||....||        ||.| ||..|::  :|..|.:||:...:.:.|..::..|:||
Human  1238 YRTSLEKALGISSDS--------NKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRKSARRKE 1294

  Fly  1206 -------QRE----RDARD-----------------------------------QAEREKAIKEA 1224
                   |.|    ||.|:                                   :......:||.
Human  1295 FIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKEL 1359

  Fly  1225 EAKERLHR---------------------------------------EEQSR--LENQRQQAAIE 1248
            |..|:|..                                       |.|.|  |.|......|:
Human  1360 EKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIK 1424

  Fly  1249 QAQRELAARELALREQAVREEEAR------LQAIREQATREQLAREQAARE---EELRIQSLRDI 1304
            ..|| :...:|.|:|.....||.:      |:.:.....|...|...:..|   |.:..|.
Human  1425 PVQR-ITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQG---- 1484

  Fly  1305 ARREEEVRLQ---NIRDEETRIRREEEERI------------RRENESRSKREEEARIQREEI-- 1352
                 |:.||   .:.|.:|.||:..|..:            .:::..|||...::::...|:
Human  1485 -----ELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGV 1544

  Fly  1353 ----------------------TRLQTLRDQVDQQRIVTENIRKDIQVNSIFTELRYASPLFTRP 1395
                                  .::......::.::...::||:.||..:|..:.....|:....
Human  1545 TEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPK 1609

  Fly  1396 LKDAVSREG--DRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKT-TFDK--GICRL-VIEETFA 1454
            ...|..::|  |....:.:..|:.:|      |.|||.:.:...| ..||  |.|.| |:...|.
Human  1610 TAPATRQKGRRDGEDLDSQGDGSSQP------DTISIASRTSQNTLDSDKLSGGCELTVVIHDFT 1668

  Fly  1455 ADSARFSCRASNLVGTCDTNATLSVRENAAEVQLVPPR------ILRFLQSGKATEGSSFQFACV 1513
            |               |::| .|::|.......|..|.      ::|......|.||.
Human  1669 A---------------CNSN-ELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL------- 1710

  Fly  1514 VAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVFLEDDAVYTCS--ASNPAGIEHCSA 1576
               ||..::       ||..|          .::::.|.:|...|::...|  ||.||.:    |
Human  1711 ---VPCGSL-------CIAHS----------RSSMEMEGIFNHKDSLSVSSNDASPPASV----A 1751

  Fly  1577 SLIVEPLEPTELPSFKVP--------------LSNAMA-----------RVGQKIKLEAIVG--- 1613
            ||....:.....|..|.|              ||:..|           :..::::..|..|
Human  1752 SLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSREVRKSADAGSQK 1816

  Fly  1614 ------GIPRPEVY-------WLHNGK------------------------PFQPRDSKYEYGRV 1641
                  ..|:.|..       .|.:|.                        |..|..:..::
Human  1817 DSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQH--- 1878

  Fly  1642 TLIIPQAYPNDAGSYVL-----SAKNLAGEAYTSCNVIVKGRLPNE------------------- 1682
            :|:.|.:..:.|.|.:|     |....|.|..::...:||.::..|
Human  1879 SLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFN 1943

  Fly  1683 TSDSEMASDIEPIKPAV----------HLPLKDVSIFEGKPVR---------------------- 1715
            .||:.:.|...||....          |..|:::...|...||
Human  1944 PSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDM 2008

  Fly  1716 --LDCVIVGQPEPEVIWYHN------ERPVKESADVQLLF---------------QGDRCSLIIQ 1757
              .|.::.|.......|:.:      |:.:::...:..||               ...:...|:.
Human  2009 KGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVS 2073

  Fly  1758 E---VYQED----AGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFER 1815
            |   .:.||    .||                .|::|.| ..:|..|..            |::.
Human  2074 EYIDTFFEDLKQRLGH----------------RLQLTDL-LIKPVQRIM------------KYQL 2109

  Fly  1816 LLSDVL---------ADEGEQVVLEVQASGDQPLTAQWFLTNKELQ-LDQRITTQSDSELGVFKL 1870
            ||.|.|         ..|.|:.| ||...  .|......:....|| .|.:|..|.       ||
Human  2110 LLKDFLKYSKKASLDTSELERAV-EVMCI--VPRRCNDMMNVGRLQGFDGKIVAQG-------KL 2164

  Fly  1871 ILNN---VSGDDKGV-------------YTVKVTNPAGDAKCFS---HLIVKSVNAPENRRSSQS 1916
            :|.:   |:..|.|:             ..|..:.|....|.||   .|...|:..     |...
Human  2165 LLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV-----SCLC 2224

  Fly  1917 SVEIIERHQCPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHW-------------FFN--DQP 1966
            ..|.:|...|   |...:.:.|::.|..   .:....|:.:..|             |.|  ..|
Human  2225 LEENVENDPC---KFALTSRTGDVVETF---ILHSSSPSVRQTWIHEINQILENQRNFLNALTSP 2283

  Fly  1967 VH---------------------------------GHN-------FLVSTSGERQVLTIQKLTHD 1991
            :.                                 ||:       ...|||..|.....|.:.|.
Human  2284 IEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRHH 2348

  Fly  1992 AVGKISCVAENEAGKATCVAFLNIRGSGLP-----------ASSDVQTVSQEHNTESSRVTIKKQ 2045
            ....:|..|.::| :|..::..:..|..||           |.|.....:....:|.....|.|.
Human  2349 PPVLVSSAASSQA-EADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAEGSEREAEPIPKM 2412

  Fly  2046 TFTTTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVE------SHHYQELHKSK-EM 2103
            ....:......:..|::|......:.|.:  ....||:.|.....      |.....|.|.. ..
Human  2413 KVLESPRKGAANASGSSPDAPAKDARASL--GTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPP 2475

  Fly  2104 SSPTVQQKSF-SFIQSSGANGQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQ------------ 2155
            |||..:..|| |.|.:|.|:...:...|.....|:|: .||...|  ||..|:
Human  2476 SSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQ-TPRHAAP--GKDTDRMSTCSSASEQSV 2537

  Fly  2156 ------GADVSMEA--------------------IYDG-----------------------FPSP 2171
                  |::.|..:                    :|.|                       .|:.
Human  2538 QSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQILASNQQNMFLVFRAATDQCPAA 2602

  Fly  2172 E-------------IKVEKNGGQLFEDA--HT--RISNKCNRVTIELKQVGVGDAG--RYAVTAS 2217
            |             :.||...|.|.:..  ||  |:..|..:...:.|:.|..:.|  :.....|
Human  2603 EGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRKKSEKKDKDGKREGKLENGYRKSREGLS 2667

  Fly  2218 NTVGQSTSTADLVVKKTIF--PPVFGRRLQAQVSKKGEKLTMEVEVTGLPEPTVTWLKDDKPLKD 2280
            |.|     :..|:....|:  ||.|...|.....:.||.:.:...|.|.|:.::||..
Human  2668 NKV-----SVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKG------- 2720

  Fly  2281 AGISEHRLLAQGNSY----------RLIIEKAQTTDSGKYMVRATNAGGEAKSIADCAILEP 2332
               .||..|.....|          .|.|....|.|.|.|...|.|..|.|.|.|...:|.|
Human  2721 ---PEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103	27/123 (22%)
		SPEC	<504..641	CDD:295325	31/150 (21%)
		COG1340	960..1298	CDD:224259	96/476 (20%)
		RILP-like	<1190..1315	CDD:304877	36/223 (16%)
		MAP7	1233..1365	CDD:283355	31/181 (17%)
		I-set	1390..1479	CDD:254352	22/94 (23%)
		IGc2	1403..1469	CDD:197706	17/71 (24%)
		I-set	1491..1580	CDD:254352	21/96 (22%)
		IGc2	1504..1570	CDD:197706	14/67 (21%)
		I-set	1589..1675	CDD:254352	22/155 (14%)
		Ig	1605..1675	CDD:299845	16/114 (14%)
		I-set	1702..1786	CDD:254352	17/135 (13%)
		Ig	1713..1786	CDD:299845	15/124 (12%)
		I-set	1811..1902	CDD:254352	28/119 (24%)
		Ig	1828..1892	CDD:143165	17/80 (21%)
		I-set	1927..2015	CDD:254352	20/142 (14%)
		IGc2	1940..2005	CDD:197706	16/119 (13%)
		I-set	2142..2231	CDD:254352	27/168 (16%)
		Ig	2158..2231	CDD:299845	20/134 (15%)
		I-set	2238..2325	CDD:254352	25/96 (26%)
		Ig	2254..2324	CDD:299845	19/79 (24%)
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
TRIO	NP_009049.2	SEC14	69..204	CDD:214706
		SPEC	230..445	CDD:238103	40/218 (18%)
		Spectrin 1	311..418		22/106 (21%)
		SPEC	341..566	CDD:238103	44/234 (19%)
		Spectrin 2	538..644		26/121 (21%)
		SPEC	567..783	CDD:238103	51/265 (19%)
		SPEC	787..1014	CDD:238103	45/237 (19%)
		Spectrin 3	878..984		16/105 (15%)
		SPEC	908..1137	CDD:238103	39/233 (17%)
		Spectrin 4	1109..1216		25/108 (23%)
		SPEC	1143..1243	CDD:197544	31/110 (28%)
		RhoGEF	1295..1465	CDD:238091	25/170 (15%)
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060	19/130 (15%)
		PH	1505..1590	CDD:278594	7/84 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1650		11/54 (20%)
		SH3_Kalirin_1	1659..1718	CDD:212786	16/91 (18%)
		SH3-RhoG_link	1715..1972	CDD:293215	44/280 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1779..1906		17/129 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1965		5/37 (14%)
		RhoGEF	1970..2143	CDD:238091	33/204 (16%)
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061	30/155 (19%)
		PH	2175..2271	CDD:278594	18/106 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2287..2552		49/270 (18%)
		SH3_Kalirin_2	2555..2613	CDD:212787	4/57 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2639..2660		4/20 (20%)
		I-set	2685..2776	CDD:254352	26/100 (26%)
		Ig	2699..2776	CDD:299845	23/86 (27%)
		STKc_Trio_C	2788..3050	CDD:271015
		S_TKc	2796..3050	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810