DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and Kalrn

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	XP_011244253.1	Gene:	Kalrn / 545156	MGIID:	2685385	Length:	2999	Species:	Mus musculus

Alignment Length:	2420	Identity:	446/2420 - (18%)
Similarity:	782/2420 - (32%)	Gaps:	836/2420 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 IQLVIALLQSPEKIYIKVVELEPKITALGENLDESLRMQREHDETLRNLQSLPGPMDEFVQKADK 171
            :|.|:..:::..:.::.      |.|.:|::|..:..:|:.||:.....|:.....|:.::.|::
Mouse   553 VQQVLDWIENHGEAFLS------KHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQ 611

  Fly   172 LLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILCTQFHDKMTQCFRKMDQLELACEETL 236
            |..:.....|.:...|..|.:..||.:..::.|:.||.:...||....:.:..|:.|:....|.:
Mouse   612 LAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEVLEDV 676

  Fly   237 HPPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQL------------------------- 276
            ....|..|||.:.:|:|.:...|...:..:|:|.:|:.||
Mouse   677 CADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPTEARDSAMSNNKTPH 741

  Fly   277 ---------------------EEL----------------------EKLETLDTRPEHIKR---- 294
                                 |||                      |....||...|.:.|
Mouse   742 SSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND 806

  Fly   295 ----DATRA---------------------------VH-----------------------QVQQ 305
                |.|.|                           :|                       |||:
Mouse   807 FNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGIELICEKDLDLAAQVQE 871

  Fly   306 WLEALHDRRNSLEL-AWQTRKIQMEQCLALALLGRELVDLEAALQQARMELNTMY----SLGECE 365
            .||.||::::.||| |.||.| ::||||.|..|..|:..:...::.....||...    ||.|.|
Mouse   872 LLEFLHEKQHELELNAEQTHK-RLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAE 935

  Fly   366 HTANEMLTKYREWKQQALLL------------RDRALKITRAKEKVQSAGHFTEEDACARAYAVL 418
            ..       .||.:|..|.:            ...||::.:..|.:..|||:   ||.|     :
Mouse   936 QL-------QREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEALLQAGHY---DADA-----I 985

  Fly   419 SGCTEHLDLVDQREHW-------------LHQSREFFAKAEHTVSVLEKLELELT--------SV 462
            ..|.|.:.|     ||             ::.|..|:..:|...||||.||.|..        ..
Mouse   986 RECAEKVAL-----HWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRD 1045

  Fly   463 KLPPHSPESYA--MFSK--------------VDRDVRNFTEEPLRLGYGILDEVGRTQPETQGVK 511
            ||.|.:...:.  :.||              ..|:...|.:...|....:......|:...|.||
Mouse  1046 KLGPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVK 1110

  Fly   512 RVLDEL---ENRKVYIQGICANSSED-QQKVQRALSEFLNHHNELLAWLRASGQHQLQQSVDMGG 572
            .:|.||   |||.::...:.....:. ||.|     .|.....:.|.|::.:|::.|......|.
Mouse  1111 AILSELLQRENRVLHFWTLKKRRLDQCQQYV-----VFERSAKQALDWIQETGEYYLSTHTSTGE 1170

  Fly   573 NLQQAKQFLLQHHELMQDLEIKGELINLLLESIKVHLESLSPQERYDVDSKAESLHKHWIELKDL 637
            ..::.::.|.::.|.....:...|.:.||::.               .||..|..|.|..|::..
Mouse  1171 TTEETQELLKEYGEFRVPAKQTKEKVKLLIQL---------------ADSFVEKGHIHATEIRKW 1220

  Fly   638 VL---KRVDYVSLLIDFFELANELS---SQLDNLQRQLQQTP---DEHKLQFLQATWTGIASTFG 693
            |.   |.....||.:..:..:.|.:   :..||...:|...|   .:.:::...|.     ....
Mouse  1221 VTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVKLRDAN-----HEIN 1280

  Fly   694 ELK---SRGQRFINLKIVDPYLET-KSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEKREVEY 754
            |.|   :|.:.||..::    |:| |:..:.:.|.|..:   ..::||.:|.....|..|..:.:
Mouse  1281 EEKRKSARKKEFIMAEL----LQTEKAYVRDLHECLETY---LWEMTSGVEEIPPGILNKEHIIF 1338

  Fly   755 -LLEKVMSDNEETVAKS----------------TQVDT-QLYPVFTSQSVDSKQLL--------- 792
             .::::...:.....|.                |..|. |:|..:.....||.||:
Mouse  1339 GNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFD 1403

  Fly   793 -ISTREKLTNVIQD----------------------IERAQDEIQQRIQTTLGIQTKDQPSLAKI 834
             |..|..|.|.|..                      .|..:.|::..::..|.:..|...::
Mouse  1404 EIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAM--- 1465

  Fly   835 EQVINNLRMLKAKLDGIKYDYRTLVESVIQFLENIVQLRR---------EIDDYFARQQKEPASG 890
                 ::.||:...:.:......:::...|..:....:|:         ||...|:::.|: :||
Mouse  1466 -----HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKD-SSG 1524

  Fly   891 ------------ADRSIAEHEKFRDQCMDKFRSLITQSELLIDRVRVLEP----------PGARE 933
                        ::..:.||.: .|.|.....|..|.|.   |...||:.          ...||
Mouse  1525 HTKYVYKNKLLTSELGVTEHVE-GDPCKFALWSGRTPSS---DNKTVLKASNIETKQEWIKNIRE 1585

  Fly   934 IDTDRILKLLENLRLHFE-SNSSARMSTLERLEKIEQFRSDLEDIDRSLDSVSQQLHEINNQSVD 997
            :..:||:.|...|:...: ..:.|::....:       |..:||.|...|..||.         |
Mouse  1586 VIQERIIHLKGALKEPIQLPKTPAKLRNNSK-------RDGVEDGDSQGDGSSQP---------D 1634

  Fly   998 SLAAAKTTSLAFEYFERTIE-------CSMPRQLK--STRHQRRWG-QTAHTIELLEKRIEK--- 1049
            :::.|..||      :.|:|       |.:...|:  |..|..... |...|:||||:..|:
Mouse  1635 TISIASRTS------QNTVESDKLSGGCELTVVLQDFSAGHSSELSIQVGQTVELLERPSERPGW 1693

  Fly  1050 -FTESTSQQLFITNPESERYVKDELRKLNEKWQSFKDQVKQKRKSLNQATDFFEVVEKIDAEYRE 1113
             ...:|.:     :|..|..|......::..            :|..:...||.:.:
Mouse  1694 CLVRTTER-----SPPQEGLVPSSALCISHS------------RSSVEMDCFFPLKD-------- 1733

  Fly  1114 ISYFYTSVSN-----KVPYLRDSVEAGNL---------VNDIENYVTSREAALRSKLDSASQCAH 1164
             ||.::|..|     .|.:|:......::         .|.::.::||....|.|.
Mouse  1734 -SYSHSSSENGGKSESVAHLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSG--------- 1788

  Fly  1165 DMNKVSSLYNDVMNIFQSFIKLKMDINVVQERLKQEQRQKEQRERDAR----------------- 1212
                                  |.|.|:          :|:::.||.|
Mouse  1789 ----------------------KADGNI----------KKQKKVRDGRKSFDLGSPKPGDETTPQ 1821

  Fly  1213 -DQAEREKAIK---EAEAKERLH---------------REEQSRLENQRQ-------QAAIEQAQ 1251
             |.|: ||:.|   |.|..|..|               ::|.|.|...||       .|.:..|.
Mouse  1822 GDSAD-EKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQAPPDVPTAADLVSAI 1885

  Fly  1252 RELAARELALREQAVR-----------------------EEEARLQAIR-EQATREQLAREQAAR 1292
            .:|...:|.|...:.|                       |||.:.:|:| ......:|.:.:...
Mouse  1886 EKLVKNKLTLEGGSYRGSLKDPTGCLNEGMTPPTPPRNLEEEQKAKALRGRMFVLNELVQTEKDY 1950

  Fly  1293 EEELRI-----------QSLRDIARREEEVRLQNIRD----------EETRIRREEEERIRR--- 1333
            .::|.|           :.:.:..|.:|::...||..          .|.....:|::|:.:
Mouse  1951 VKDLGIVVEGFMKRIEEKGVPEDMRGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFI 2015

  Fly  1334 -------------ENESRSKREEEARIQREEITRLQTLRDQVDQQRIVTENIRKDIQVNSIFTEL 1385
                         :|:.||:     .|..|.....:.::.:::|:..:::.:.|.||..:.:..|
Mouse  2016 KHERKLHIYVWYCQNKPRSE-----YIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLL 2075

  Fly  1386 RYASPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWF------------------------KD 1426
                      |||.: |..::...||   ...|.|||..                        ..
Mouse  2076 ----------LKDFL-RYSEKAGLEC---SDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQ 2126

  Fly  1427 GISIQTNSDYKTTFDKGICR---------------------------------------LVIEET 1452
            |..:|.::.|....|.|:..                                       ||:|:.
Mouse  2127 GKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEDN 2191

  Fly  1453 FAADSARFS-----------CRASN----LVGTCDTNATLSVR-----------------ENAAE 1485
            ...|..:|:           .:|:|    .....|.|..|..:                 .:.|.
Mouse  2192 VDGDPCKFALMNRETSERVILQAANSDIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAV 2256

  Fly  1486 VQLVPPRI----LRFLQSG-----KATEGSSFQFACVVAGVPLPTVQWFKN------------DK 1529
            ::..|||:    .|...||     |..:|||:       ..|||.::...:            ||
Mouse  2257 IRSQPPRVPQASPRPYSSGPVGSEKPPKGSSY-------NPPLPPLKISTSNGSPGFDYHQPGDK 2314

  Fly  1530 CIDDSPDYVISYNNGEAT---------LKFEEVFLEDDAVYTCSASNPAGIEHCSASLIVEPLEP 1585
             .|.|....:...||.:|         ||..|:.:....|....|.|...:  |   |:.:|...
Mouse  2315 -FDASKQNDLGGCNGTSTMTVIKDYYALKENEICVSQGEVVQVLAVNQQNM--C---LVYQPASD 2373

  Fly  1586 TE------LP-SFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLHNGKPFQPRDSKYEYGRVTL 1643
            ..      :| |...||:.|.|..      |:..|.| :....| |..: .:.|......|:...
Mouse  2374 HSPAAEGWVPGSILAPLAKATAAA------ESSDGSI-KKSCSW-HTLR-MRKRADVENSGKNEA 2429

  Fly  1644 IIPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVKGRLPNETSDSEMASDIEPIKPAVHLPLKDVSI 1708
            ..|:. |.|.....:|.|.......:.|:.:.    ||.:.:....:.|:.:.|...:||.||:.
Mouse  2430 TGPRK-PKDILGNKVSVKETNSSEESECDDLD----PNTSMEILNPNFIQEVAPEFLVPLVDVTC 2489

  Fly  1709 FEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLLFQGDRC-----SLIIQEVYQEDAGHYK 1768
            ..|..|.|.|...|:|:|.:.|...::.:.::.:....:....|     :|.|..:..:|:|.|.
Mouse  2490 LLGDTVLLQCKACGRPKPSITWKGPDQNILDTDNSSATYTISSCDSGESTLKICNLMPQDSGIYT 2554

  Fly  1769 VVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFERLLSDVL------ADEGEQ 1827
            .:|.|..|.||:|..:||    |..||...:...|          ||..:.|:      |..|..
Mouse  2555 CIAANDHGTASTSATVKV----QGVPAAPNRPIAQ----------ERSCTSVILRWLPPASTGNC 2605

  Fly  1828 VV----LEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSELGVFKLILNNVSGDDKGVYTVKVT 1888
            .:    :|.:..|.|    .|         .|.:.:..|:     .|::.::|......:.|..:
Mouse  2606 TISGYTVEYREEGSQ----VW---------QQSVASTLDT-----YLVIEDLSPGCPYQFRVSAS 2652

  Fly  1889 NPAGDAKCFSHLIVKSVNAPENRRSSQSSVEIIERHQCPEF-----------KELFSDKQGEIDE 1942
            ||.|            ::.|.         |..|..:.||:           ||.|.....|::|
Mouse  2653 NPWG------------ISLPS---------EPSEFVRLPEYDAAADGATISWKENFDSAYTELNE 2696

  Fly  1943 V------IKFECIVK 1951
            :      |..:||.|
Mouse  2697 IGRGRFSIVKKCIHK 2711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103	64/332 (19%)
		SPEC	<504..641	CDD:295325	30/143 (21%)
		COG1340	960..1298	CDD:224259	76/432 (18%)
		RILP-like	<1190..1315	CDD:304877	35/202 (17%)
		MAP7	1233..1365	CDD:283355	31/199 (16%)
		I-set	1390..1479	CDD:254352	25/166 (15%)
		IGc2	1403..1469	CDD:197706	18/143 (13%)
		I-set	1491..1580	CDD:254352	27/118 (23%)
		IGc2	1504..1570	CDD:197706	19/86 (22%)
		I-set	1589..1675	CDD:254352	19/86 (22%)
		Ig	1605..1675	CDD:299845	13/69 (19%)
		I-set	1702..1786	CDD:254352	24/88 (27%)
		Ig	1713..1786	CDD:299845	19/77 (25%)
		I-set	1811..1902	CDD:254352	17/100 (17%)
		Ig	1828..1892	CDD:143165	11/67 (16%)
		I-set	1927..2015	CDD:254352	11/42 (26%)
		IGc2	1940..2005	CDD:197706	5/18 (28%)
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Kalrn	XP_011244253.1	SEC14	47..185	CDD:214706
		SPEC	198..418	CDD:238103
		SPEC	319..544	CDD:238103
		SPEC	545..774	CDD:238103	41/226 (18%)
		SPEC	899..1137	CDD:238103	55/257 (21%)
		SPEC	1143..1243	CDD:197544	21/114 (18%)
		RhoGEF	1292..1462	CDD:238091	30/176 (17%)
		PH1_Kalirin_Trio_like	1469..1591	CDD:270060	22/126 (17%)
		SH3_Kalirin_1	1657..1716	CDD:212786	14/63 (22%)
		SH3-RhoG_link	1714..1929	CDD:374666	44/277 (16%)
		RhoGEF	1939..2108	CDD:366202	30/187 (16%)
		PH2_Kalirin_Trio_p63RhoGEF	2113..2247	CDD:270061	15/133 (11%)
		Extensin_2	2259..2311	CDD:252669	13/58 (22%)
		SH3_Kalirin_2	2331..2387	CDD:212787	12/60 (20%)
		I-set	2478..2572	CDD:369462	25/93 (27%)
		FN3	2576..2667	CDD:238020	23/139 (17%)
		STKc_Kalirin_C	2697..2944	CDD:271017	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900