DRSC/TRiP Functional Genomics Resources

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Protein Alignment zormin and MYLK

DIOPT Version :9

Sequence 1:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster
Sequence 2:XP_024309300.1 Gene:MYLK / 4638 HGNCID:7590 Length:1924 Species:Homo sapiens


Alignment Length:2516 Identity:475/2516 - (18%)
Similarity:788/2516 - (31%) Gaps:885/2516 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1389 SPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFD---KGICRLVIE 1450
            :|.|..|.::...:||....||..|.|.|||.|.|.::|..|.:...:  ..|   :|...|||.
Human    42 APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRF--LLDCGIRGTFSLVIH 104

  Fly  1451 ETFAADSARFSCRASNLVGTCDTNATLSV-------------------RENAAEVQL-------V 1489
            .....|..:::|.|:|..|.......|:|                   |.:|..|:.       .
Human   105 AVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGEC 169

  Fly  1490 PPRILRFLQSGKATEGSSFQFACVVAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVF 1554
            ||:....|......||...:|:|.:.|.|.|.|.|.|.:..:..|....:|..||...|:...|.
Human   170 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVN 234

  Fly  1555 LEDDAVYTCSASNPAGIEHCSASLIVEPLEPTELPSF-----------KVPLSNAMARVGQKIKL 1608
            .:|..||||...|.:|....||.|.::.|:... .||           :..::|.:::..:...|
Human   235 QDDVGVYTCLVVNGSGKASMSAELSIQGLDSAN-RSFVRETKATNSDVRKEVTNVISKESKLDSL 298

  Fly  1609 EAIV----------GGIPRPEVYWLHNGKPFQPRDSKYE------------------YGRVTL-- 1643
            ||..          ||.|.    |..|.:|..||:||.|                  ...:||  
Human   299 EAAAKSKNCSSPQRGGSPP----WAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQA 359

  Fly  1644 --IIPQAYPNDAGSYVLSAKNLAGE------------------AYTSCNVIVKG---RLPNETSD 1685
              :.|:  |...|..|||.   :||                  ...|.:|:.|.   |:|.|...
Human   360 ARVQPE--PRAPGLGVLSP---SGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQR 419

  Fly  1686 SEMASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPV-KESADVQLLFQG 1749
            .......|. ||      :...:.|.:.|:..|.:.|.|:|||.|:....|| ::...:::....
Human   420 DSAFPKFES-KP------QSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDA 477

  Fly  1750 DRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFE 1814
            ....|.:.:....|:|.|...|.|:.|:.|.|..|:|..|...|.|               |.|.
Human   478 GSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVA---------------PSFS 527

  Fly  1815 RLLSDVLADEGEQVVLEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSELGVFKLILNNVSGDD 1879
            .:|.|....||:..||                                                 
Human   528 SVLKDCAVIEGQDFVL------------------------------------------------- 543

  Fly  1880 KGVYTVKVTNPAGDAKCFSHLIVKSVNAPENRRSSQSSVEIIERHQCPEFKELFSDKQGEIDEVI 1944
                                                                             
Human   544 ----------------------------------------------------------------- 543

  Fly  1945 KFECIVKGKPTPKVHWFFNDQPVHGHNFLVST--SGERQVLTIQKLTHDAVGKISCVAENEAGKA 2007
              :|.|:|.|.|::.|..|.||:   .:..||  :|..: |.||....:..|..:|:|||..|:.
Human   544 --QCSVRGTPVPRITWLLNGQPI---QYARSTCEAGVAE-LHIQDALPEDHGTYTCLAENALGQV 602

  Fly  2008 TCVAFLNIRGSGLPASSDVQTVSQEHNTESSRVTIKKQTFTTTSTSQVNSYEGNAPQTEVHHSSA 2072
            :|.|::.:                 |..:|||                                 
Human   603 SCSAWVTV-----------------HEKKSSR--------------------------------- 617

  Fly  2073 HIDQSLKQLGQQRPEIVESHHYQELHKSKEMSSPTVQQKSFSFIQSSGANGQSAVAIPDSPTRLR 2137
                                                               :|...:|.:|:   
Human   618 ---------------------------------------------------KSEYLLPVAPS--- 628

  Fly  2138 REIAPRFTTPLSGKIVDQGADVSMEAIYDGFPSPEIKVEKNGGQLFEDAHTRISNKCNRVTIELK 2202
            :..||.|...||...|..|:.|:|.....|.|.||:....||.::.|........:..:.::.::
Human   629 KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQ 693

  Fly  2203 QVGVGDAGRYAVTASNTVGQSTSTADLVVKKTIFP-----PVFGRRLQAQVSKKGEKLTMEVEVT 2262
            :|...|.|.|...|.|:.|:..:.|.|.|::   |     |.|..:.::..:..|:.:.:...:.
Human   694 EVFPEDTGTYTCEAWNSAGEVRTQAVLTVQE---PHDGTQPWFISKPRSVTASLGQSVLISCAIA 755

  Fly  2263 GLPEPTVTWLKDDKPL-KDAGISEHRLLAQGNSYRLIIEKAQTTDSGKYMVRATNAGGEAKSIAD 2326
            |.|.|||.||:|.|.| ||.|..|  :|...:.:.|:::|.|...:|:|.:...|..||......
Human   756 GDPFPTVHWLRDGKALCKDTGHFE--VLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVS 818

  Fly  2327 CAILEPS---------PERLQEVVKTIVYETG----------PVAPA-----------SEFKTEV 2361
            ..:...|         |...:::....|...|          |..||           .:.:..:
Human   819 LMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVL 883

  Fly  2362 QKQIQNSEN-QQSYQNSQTEVTSANDLHGLSES-KVITEHRCTTEATMRLEHKSNYLDLPELTTR 2424
            :::::..:: :::.:..:.|.....||.|...| |.::|.........:::.::|.    :...:
Human   884 KRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANL----QRQVK 944

  Fly  2425 PKTPTTNDTITITTNTATVSMDQPDLTQP------TITNTTTTNTTKVPPPV-PPKPCTPVVATT 2482
            ||               |||.::..:..|      ::.....|:.|.||..| ||||.||...:.
Human   945 PK---------------TVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSV 994

  Fly  2483 FGQQQQQP-------PQTLTSTRYEQSEHKSTTSSSSFDYFKKIDEETIIQRPNPL-------TF 2533
            .|.:::.|       .:||.:...|.|:..|....|.  ..|.:......:...|:       |.
Human   995 LGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSG--PLKPVGNAKPAETLKPMGNAKPAETL 1057

  Fly  2534 KPL-----DTVVRQPQAQSLAEELRS-LNLIPGDAPEFCYSPKTERSEPKIPLITEKIKILSEVQ 2592
            ||:     |..::....:.|.::::: :|...|.|..   :...:|||                 
Human  1058 KPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGT---TDNEKRSE----------------- 1102

  Fly  2593 PKEPPPQGGVPVFPPPLGLQTVQHESTTTKEVKVEYGQPIVRPAAVLATPAQQNPRSPSPKPSAE 2657
                 .||..|.|...|            ::|.|..|:.::....|.:.|           |:  
Human  1103 -----SQGTAPAFKQKL------------QDVHVAEGKKLLLQCQVSSDP-----------PA-- 1137

  Fly  2658 GVAMSRLWTPTGVTGYTSDVEQKSEKTVISKLATPTPTKELNAPFLVNQIAKSIPPTTAPVTHLV 2722
                :.:||..|.|..|:.....|::..:..::......|...  |...:||: ....|..:..|
Human  1138 ----TIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRG--LYKCVAKN-DAGQAECSCQV 1195

  Fly  2723 NVELEPGTPPEICFAPKVEETRRRSLVETMEQKLEQNLIQGPSKVLPHSVPTLTPNTAAPVQPKP 2787
            .|:..|.:  |...||:::..|                   |...||   |.|...:.|.|:.||
Human  1196 TVDDAPAS--ENTKAPEMKSRR-------------------PKSSLP---PVLGTESDATVKKKP 1236

  Fly  2788 LGNTTYRPPPPVLPTRLGVYESDYE---SDRYKYSGSESDVEP------GIRKQPQLTTMETSFK 2843
            ...|   ||...:|.::..:..|.:   .:..:..|..:..:|      ..|||.|         
Human  1237 APKT---PPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQ--------- 1289

  Fly  2844 SSGYTADTEEHSSYRKSESSFYETKSSSTMGGAPQ---------LQTQFPKLQPEPPAPIYFTAK 2899
                      .|.:.|.|:|  |..|..|:..|.|         ::.:....|    |.:..|..
Human  1290 ----------ESEHMKVENS--ENGSKLTILAARQEHCGCYTLLVENKLGSRQ----AQVNLTVV 1338

  Fly  2900 PQPQVPPQVPPSQSNVSSQEAK----GYKYTSSSMTSNYSHNMQSSSSSSHHETKFSSTSAPPPV 2960
            .:|. ||...|..|::.|....    |..|...|...:||..:..|::.:..|.           
Human  1339 DKPD-PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKEL----------- 1391

  Fly  2961 VTYPSPIPAQRKTPAAEFSDYSSEIDERFRSVSRANESDAEIKGYRVVFPPTPTPRTNIATNGHK 3025
                    |..::.:....|...:.:.:||           ::...|.....|:..:.:.|.|.|
Human  1392 --------ATCRSTSFNVQDLLPDHEYKFR-----------VRAINVYGTSEPSQESELTTVGEK 1437

  Fly  3026 SPVVVITPSPM-EFEPTPQDYARPKFEPISKEIRHEIKT------ETSSKQSKFMQNQQQNQPVF 3083
                  ...|. |.|.:..|...|:.:..:..|..|.|.      |......||.|       ||
Human  1438 ------PEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQ-------VF 1489

  Fly  3084 K------PKPVAAKFIAATQQQQQKQPQATSRPTMYYNAVAGAPMHVAKVATETKNVMQMHESTE 3142
            :      .|..|.||..|                  |:            |.|.:|:.|     |
Human  1490 RLVEKKTRKVWAGKFFKA------------------YS------------AKEKENIRQ-----E 1519

  Fly  3143 SSQRVVN-MQQTKRIIHFDSPQEQRD-QQILEPFPYSPATSRTPSRQSHLPPPATPTKFVPG--- 3202
            .|  ::| :...|.:...|:.:|:.: ..:||                          .|.|   
Human  1520 IS--IMNCLHHPKLVQCVDAFEEKANIVMVLE--------------------------IVSGGEL 1556

  Fly  3203 --EFRESDYESEIDGARIQPLWSPYGDGMTKGFRRVAPPQGAGRSCSLPRTYERVLSPMEFDRGP 3265
              ...:.|:|                  :|:            |.|.   .|.|.:|     .|.
Human  1557 FERIIDEDFE------------------LTE------------RECI---KYMRQIS-----EGV 1583

  Fly  3266 EMPSK---IHVDINTLRKEQRGGSTVTTQNRTQSLNRNTTMRQQQQQQQQQSMDQIDRAGTLPRY 3327
            |...|   :|:|:                                   :.:::..:::.||..:.
Human  1584 EYIHKQGIVHLDL-----------------------------------KPENIMCVNKTGTRIKL 1613

  Fly  3328 GYSSLQQQAENQGRRMGSTFLQKSHQFVDDVSREIRSSASNGIRPGFKRAPSEGSSQQPQAFRDE 3392
            ....|.::.||.|   ....|..:.:||                     || |..:.:|..:..:
Human  1614 IDFGLARRLENAG---SLKVLFGTPEFV---------------------AP-EVINYEPIGYATD 1653

  Fly  3393 SRVSQYGTKCVDPNTGLIYF---------------KYDFGYEFGILFPGEGHKFVSS-------- 3434
              :...|..|....:||..|               .:||..|.......:...|:|:        
Human  1654 --MWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKN 1716

  Fly  3435 ----------QWNSSGSSNSNAKPIQNGRHSPYPLK---LPPGNELVIPVQHERSAQGYSSDNEV 3486
                      .|....:.|..||.:...|...|..:   ...||.:        .|.|..|...:
Human  1717 RLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV--------RAIGRLSSMAM 1773

  Fly  3487 QRRSQTRNWSTTKPMAPRTINSHKRYSLPSGHSLDIHLDRLHAQAPRLPPDQMIRTVPELPNTEP 3551
            ......|..||..|.:|  :|:.|..|     ..|:....|.|.|...|                
Human  1774 ISGLSGRKSSTGSPTSP--LNAEKLES-----EEDVSQAFLEAVAEEKP---------------- 1815

  Fly  3552 VNAHLSRDELAQRQPLFITPLKDIAVGVGGTARFECIVQAHPQPQVNWTHNGGLLESGSRHCIEY 3616
               |:        :|.|...::|:.|..|..|||:|.::.:|.|:|.|..:...:.......|:|
Human  1816 ---HV--------KPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDY 1869

  Fly  3617 -RNGVCRLTLPQAYPDDNGSYACTAINPLGAATTSGNLTVSSTNRG 3661
             .:|.|.|.:.....||:..|.|.|:|.||.||.:..|.|.:...|
Human  1870 DEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEG 1915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zorminNP_001261317.1 SPEC 126..332 CDD:238103
SPEC <504..641 CDD:295325
COG1340 960..1298 CDD:224259
RILP-like <1190..1315 CDD:304877
MAP7 1233..1365 CDD:283355
I-set 1390..1479 CDD:254352 27/91 (30%)
IGc2 1403..1469 CDD:197706 22/68 (32%)
I-set 1491..1580 CDD:254352 28/88 (32%)
IGc2 1504..1570 CDD:197706 22/65 (34%)
I-set 1589..1675 CDD:254352 29/146 (20%)
Ig 1605..1675 CDD:299845 26/119 (22%)
I-set 1702..1786 CDD:254352 21/84 (25%)
Ig 1713..1786 CDD:299845 20/73 (27%)
I-set 1811..1902 CDD:254352 8/90 (9%)
Ig 1828..1892 CDD:143165 2/63 (3%)
I-set 1927..2015 CDD:254352 23/89 (26%)
IGc2 1940..2005 CDD:197706 20/66 (30%)
I-set 2142..2231 CDD:254352 24/88 (27%)
Ig 2158..2231 CDD:299845 18/72 (25%)
I-set 2238..2325 CDD:254352 26/87 (30%)
Ig 2254..2324 CDD:299845 23/70 (33%)
I-set 3566..3655 CDD:254352 29/89 (33%)
Ig 3583..3650 CDD:143165 23/67 (34%)
MYLKXP_024309300.1 I-set 43..133 CDD:254352 27/91 (30%)
I-set 171..260 CDD:254352 28/88 (32%)
23ISL 261..422 CDD:318761 34/170 (20%)
I-set 424..514 CDD:254352 24/96 (25%)
I-set 524..610 CDD:254352 31/205 (15%)
I-set 633..722 CDD:254352 24/88 (27%)
I-set 731..819 CDD:254352 26/89 (29%)
I-set 1108..1197 CDD:254352 21/120 (18%)
Ig8_hMLCK_like 1248..1345 CDD:143239 21/122 (17%)
FN3 1341..1433 CDD:238020 19/122 (16%)
STKc_MLCK1 1471..1729 CDD:271093 62/427 (15%)
I-set 1819..1909 CDD:254352 29/89 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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