DRSC/TRiP Functional Genomics Resources

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Protein Alignment zormin and trio

DIOPT Version :10

Sequence 1:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster
Sequence 2:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster


Alignment Length:1459 Identity:261/1459 - (17%)
Similarity:500/1459 - (34%) Gaps:357/1459 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 QQSQQSQQSQLDAFNYSATMSSSSPTPSQAMSTAMSTGTGTGTGTTHTTPPSSSSLRATTIGTVV 101
            ||||.||||:         ....:|..|.|::.|                     ||...:    
  Fly   260 QQSQPSQQSR---------SVGGNPDMSAAVNKA---------------------LRQIEL---- 290

  Fly   102 VRCGPIQLVI----------------ALLQSPEKIYIKVVE----LEPKITALGENLDESLRMQR 146
            :..|..:|::                ...|..||::..::.    .:.....:|.|...:..:|.
  Fly   291 IHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQD 355

  Fly   147 EHDETLRNLQSLPGPMDEFVQKADKLLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILC 211
            ||.:......::...:|..:..|.:|:.|:..:::.:..:|..|:..|:|....|.:|..:|.|.
  Fly   356 EHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLS 420

  Fly   212 TQFHDKMTQCFRKMDQLELACEETLH-PPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQ 275
            ..||.|..|....:.....||:.:.. |.|:..::..:...:.|...|............:||.|
  Fly   421 VLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQ 485

  Fly   276 LEELEKLETLDTR---PEHIKR----------------DATRAVHQVQQWLEALHDRRNSLELAW 321
            |:.|.::......   |:|.|.                |.:.....|...:..:.....:||..|
  Fly   486 LDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKW 550

  Fly   322 QTRKIQMEQCLALALLGRELVD-LEAALQQARMELNTMYSLGECEHTANEMLTKYREWKQQALLL 385
            ...::::.|.|||.|...::.. |:.......:.|.....:|...|.|....|.:..::..|...
  Fly   551 HQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNT 615

  Fly   386 RDRALKITRAKEKVQSAGH-------------------FTEE--------DACARAYAVLSGCTE 423
            ...|.|:..|.:::..:|.                   |.|.        |.....|......|.
  Fly   616 YSNAQKLLAAADELARSGEADPNEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTA 680

  Fly   424 HLDLV----------------------------DQRE-------------HWLHQSREFFAKAEH 447
            .:|.:                            ||:|             ..|.|.......|::
  Fly   681 WIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADN 745

  Fly   448 TVSV------LEKL-----ELE------------------------LTSVKLPPHSPE------- 470
            |.|:      ||||     |||                        |.||::...|.|       
  Fly   746 TGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHADLS 810

  Fly   471 -SYAMFSKVDR-------DVRNFTEEPLRLGY---------GILDEVGRTQPETQGVKRVLDELE 518
             .|....::.|       :::|.|.|.::.|.         |.:.....|......::.:||.|.
  Fly   811 RDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFLR 875

  Fly   519 NRKVYIQGIC-ANSSEDQQKVQRALSEFLNHHNELLAWLRASGQHQLQQSVDMGGNLQQAKQFLL 582
            .|::.::.:. |..::.:|.||  |.:|.|..|::::|:| :|:..|..|.....:||:|:| |.
  Fly   876 EREIDLEEMSEAKRAKLEQAVQ--LCQFQNDANQVISWIR-NGEAMLVASFVTPNSLQEAEQ-LR 936

  Fly   583 QHHELMQDLEIKGELINLLLESIKVHLESLSPQERYD---VDSKAESLHKHWIELKDLVLKRVDY 644
            :.||..|   |..|..:.....:|...::|.....||   :|..::.:.|.|.:|.....:|...
  Fly   937 KGHEQFQ---IAIEKTHTSAVQVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKL 998

  Fly   645 VSLLIDFFELANELSSQLDNLQRQLQQTPDEHKLQFLQATW------TGIASTFGELKSRGQRFI 703
            |:..|:|::.|.::.|.||:|:|:.::..|          |      :..|....:|.|:.|   
  Fly   999 VTASINFYKTAEQVCSVLDSLEREYKREDD----------WCDGGGGSDKAQAIVQLISKHQ--- 1050

  Fly   704 NLKIVDPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEKREVEYLLEKVMSDNEETVA 768
              :..:.:|:..:.|:...||...::.|.........|....:..|      |:|:::...:.:.
  Fly  1051 --EQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSK------LDKLLTQENQVLD 1107

  Fly   769 KSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVIQDIERAQDEIQQRIQTTLGIQTKDQPSLAK 833
                     |.....:|:|..|..:.........|:.|....:.........:||..::...|.|
  Fly  1108 ---------YWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLK 1163

  Fly   834 IEQVINNLRMLKAKLDGIKYDYRTLVESVIQFLENIVQLRREIDDYFARQQKEPASGADRSIAEH 898
            ..   |..|. .||      :.|..|:.:||..:::|    |.....|...|:..:..|:...:.
  Fly  1164 EH---NEFRS-TAK------ETRERVKLLIQLADSLV----EKGHAHASDIKQWVASVDQRYKDF 1214

  Fly   899 EKFRDQCMDKFRSLITQSELLIDRVRVLEPPGAREIDTDRILKLLENLRLHFESNSSARMSTLER 963
            ....|...::....:..|:                          :.|.|..:.|||...|:.:|
  Fly  1215 SNRMDSYCEQLEKSLGMSQ--------------------------QQLLLGSDGNSSISSSSGDR 1253

  Fly   964 LEKIEQFRSDLEDIDRSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTIECSMPRQLKSTR 1028
                   .|| ..::..|:|.:::..|||.:...|....:.........||.....:...:|...
  Fly  1254 -------HSD-PTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFL 1310

  Fly  1029 HQRRWGQTAHTIELLE--------KRIEKFTESTSQQLFITNPESERYVKDELRKLNEKWQSFKD 1085
            .:.|.|::..:..:.:        |.|..|    .|::|:...|....:.:::......|.|..|
  Fly  1311 EEFRAGKSVPSALIGQEDVIFGNIKEIHHF----HQKIFLRELEKYETMPEDVGHCFVTWASKFD 1371

  Fly  1086 Q----VKQKRKSLN----QATDFFEVVE-KIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDI 1141
            .    .|.|..|.|    ....|||.:: :::.::...:|....|.....|..       |:.|:
  Fly  1372 MYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQL-------LLKDL 1429

  Fly  1142 ENYVTSREAALRSKLDSASQCAHDMNKVSSLYNDVMNIFQSFIKLKMDINV--VQERLKQEQRQK 1204
            .:........::..|:.       |..|....||.|::  |.:: ..|::|  :.|.:.|:..|.
  Fly  1430 LSCCEESHGEIKEGLEV-------MLNVPKKANDAMHL--SLLE-NCDVSVDKLGEVVLQDAFQA 1484

  Fly  1205 EQRERDARDQAERE-----------KAIKEA-----EAKERLHREEQ---SRLENQRQQAAIEQA 1250
            ...::..|...||.           |.:||:     :.|.:|...:.   ..:|....:.|:...
  Fly  1485 WDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTG 1549

  Fly  1251 QRE-LAARELALREQAVREEEARLQAIRE 1278
            :.. |:...:.|:..::..::..::.:||
  Fly  1550 RSPMLSDCRIVLKATSLETKQIWVKKLRE 1578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zorminNP_001261317.1 SPEC 126..332 CDD:238103 41/229 (18%)
SPEC <504..641 CDD:413338 35/140 (25%)
SMC_prok_B 654..>1389 CDD:274008 113/670 (17%)
Smc <1192..>1377 CDD:440809 18/109 (17%)
I-set 1390..1479 CDD:400151
Ig strand B 1407..1411 CDD:409564
Ig strand C 1420..1424 CDD:409564
Ig strand E 1445..1449 CDD:409564
Ig strand F 1459..1464 CDD:409564
Ig strand G 1472..1475 CDD:409564
I-set 1491..1580 CDD:400151
Ig strand B 1508..1512 CDD:409353
Ig strand C 1521..1525 CDD:409353
Ig strand E 1546..1550 CDD:409353
Ig strand F 1560..1565 CDD:409353
Ig strand G 1573..1576 CDD:409353
I-set 1589..1675 CDD:400151
Ig strand B 1606..1610 CDD:409353
Ig strand C 1619..1623 CDD:409353
Ig strand E 1641..1645 CDD:409353
Ig strand F 1655..1660 CDD:409353
Ig strand G 1668..1671 CDD:409353
I-set 1702..1786 CDD:400151
Ig strand B 1714..1718 CDD:409353
Ig strand C 1727..1731 CDD:409353
Ig strand E 1752..1756 CDD:409353
Ig strand F 1766..1771 CDD:409353
Ig strand G 1779..1782 CDD:409353
I-set 1811..1902 CDD:400151
Ig strand B 1828..1832 CDD:409353
Ig strand C 1841..1845 CDD:409353
Ig strand E 1868..1872 CDD:409353
Ig strand F 1882..1887 CDD:409353
I-set 1927..2015 CDD:400151
Ig strand B 1944..1948 CDD:409353
Ig strand C 1957..1961 CDD:409353
Ig strand E 1981..1985 CDD:409353
Ig strand F 1995..2000 CDD:409353
Ig strand G 2008..2011 CDD:409353
Ig 2142..2231 CDD:472250
Ig strand B 2159..2163 CDD:409353
Ig strand C 2172..2176 CDD:409353
Ig strand E 2197..2201 CDD:409353
Ig strand F 2211..2216 CDD:409353
Ig strand G 2224..2227 CDD:409353
I-set 2238..2325 CDD:400151
Ig strand B 2255..2259 CDD:409353
Ig strand C 2268..2272 CDD:409353
Ig strand F 2309..2314 CDD:409353
PHA03247 <2593..2893 CDD:223021
I-set 3566..3655 CDD:400151
Ig strand B 3583..3587 CDD:409353
Ig strand C 3596..3600 CDD:409353
Ig strand E 3621..3625 CDD:409353
Ig strand F 3635..3640 CDD:409353
Ig strand G 3648..3651 CDD:409353
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103 29/153 (19%)
SPEC 563..778 CDD:238103 34/214 (16%)
SPEC 782..997 CDD:238103 49/221 (22%)
SPEC 897..1119 CDD:238103 56/258 (22%)
SPEC 1125..1226 CDD:197544 20/114 (18%)
RhoGEF 1287..1455 CDD:459876 29/185 (16%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 19/118 (16%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Blue background indicates that the domain is not in the aligned region.

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