DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zormin and leo1

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_996950.1	Gene:	leo1 / 404599	ZFINID:	ZDB-GENE-040426-2435	Length:	696	Species:	Danio rerio

Alignment Length:	292	Identity:	72/292 - (24%)
Similarity:	115/292 - (39%)	Gaps:	62/292 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 DFFEVVEKIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDIENYVTSREAALRSKLDSASQCA 1163
            |.||..|.:|.|.|  :.....|.|.:.:.....|.||.|.:....:.        |....|...
Zfish   374 DEFEDEEMLDEEGR--TRLKLKVENTIRWRSRRDEEGNEVKESNARIV--------KWSDGSMSL 428

  Fly  1164 HDMNKVSSLY-----NDVMNIF---------QSFIKLKMDI------NVVQERLK---QEQRQKE 1205
            |..|:|..:|     .|..::|         |:..|.|:..      :....::.   .::..|.
Zfish   429 HLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKT 493

  Fly  1206 QRER----DARD-QAEREKAIKEAEAKER--LHREEQSRLENQRQQAAIEQAQRELAAREL---A 1260
            |:.|    ..|| :::|.:.||:.|.:.|  :.||.|.|...::|.      ||.|.|..|   .
Zfish   494 QKIRILPMAGRDPESQRNEMIKKEEERLRASIRRESQQRRMREKQH------QRGLNAGYLEPDR 552

  Fly  1261 LREQAVREEEARLQAIREQ-----ATREQLAREQAAREEELRIQSLRDIARR-EEEVRLQNIRDE 1319
            ..|....||...|.||:.:     ..||:.||..::..:|   .|..|.|:| .:..||.:..:.
Zfish   553 YDEDEEGEESISLAAIKSKYKGGGGLREERARIYSSDSDE---GSDEDKAQRLMKAKRLDSDEEG 614

  Fly  1320 ETRIRREEEERIRRENESRSKREEEARIQREE 1351
            |...:|:.||    :.||.||:.::..|..||
Zfish   615 ENSGKRKAEE----DEESASKKPKKYVISDEE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259	55/236 (23%)
		RILP-like	<1190..1315	CDD:304877	37/149 (25%)
		MAP7	1233..1365	CDD:283355	37/128 (29%)
		I-set	1390..1479	CDD:254352
		IGc2	1403..1469	CDD:197706
		I-set	1491..1580	CDD:254352
		IGc2	1504..1570	CDD:197706
		I-set	1589..1675	CDD:254352
		Ig	1605..1675	CDD:299845
		I-set	1702..1786	CDD:254352
		Ig	1713..1786	CDD:299845
		I-set	1811..1902	CDD:254352
		Ig	1828..1892	CDD:143165
		I-set	1927..2015	CDD:254352
		IGc2	1940..2005	CDD:197706
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
leo1	NP_996950.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..336
		PHA02664	<161..260	CDD:177447
		Leo1	352..510	CDD:281933	29/145 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..560		11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..696		19/66 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900