DRSC/TRiP Functional Genomics Resources

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Protein Alignment zormin and MCF2L2

DIOPT Version :10

Sequence 1:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster
Sequence 2:NP_055893.4 Gene:MCF2L2 / 23101 HGNCID:30319 Length:1114 Species:Homo sapiens


Alignment Length:1124 Identity:209/1124 - (18%)
Similarity:388/1124 - (34%) Gaps:359/1124 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   312 DRRNSLELAWQTRKIQMEQCLALALLGRELVDLEAALQQARMELNTMYSLGECEHTANEMLTKYR 376
            |||..   .|.:.|..:.: :|:|..|.  :.|...|:.:|....|...:| .::..||..||. 
Human   105 DRRRD---KWSSVKASLTR-IAVAFPGN--LQLIFILRPSRFIQRTFTDIG-IKYYRNEFKTKV- 161

  Fly   377 EWKQQALLLRDRALKITRAKEKVQSAGHFTEEDACARAYAVLSGCTEHLDLVDQREHWL-HQS-- 438
                 .:::.:....:....:|.|    .|.|         |.|..|:     :...|: |::  
Human   162 -----PIIMVNSVSDLHGYIDKSQ----LTRE---------LGGTLEY-----RHGQWVNHRTAI 203

  Fly   439 REFFAKAEHTVSVLEKLELELTSVKLPPH--SPESYAMFSKVDRDVRNFTEEPLRLGYGILDEVG 501
            ..|....:.|..:|:.....|.:.:||..  |.|...|.....||.   .::.|:|    |.:.|
Human   204 ENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDK---LQDELKL----LGKQG 261

  Fly   502 RT------QPETQ--GVKRVLDELEN----RKVYIQGICANSSEDQQKVQRALSEFLN-HHNELL 553
            .|      :|.|:  ..|..|::|||    .::.:|         ..:.::|.|.|.: ||.:|.
Human   262 TTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQ---------LDETEKAFSHFWSEHHLKLN 317

  Fly   554 AWLRASGQH--------------QLQQSVD---MGGNLQQAKQFLLQHHEL----MQDLEIKGEL 597
            ..|:.  ||              .|::..:   :|.::...:|.|.:|.:|    .:.|| |.:|
Human   318 QCLQL--QHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLE-KAQL 379

  Fly   598 INL----LLESIKVHLESLSP----------------QERYDVDSKAESLHK------HWIELKD 636
            :.|    |::|.....:::.|                ::::|:..|:...|:      .|.|...
Human   380 LALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGI 444

  Fly   637 LVLKRVDYVSLLIDFFELANELSSQLDNLQRQLQQTPDEHKLQFLQATWTGIASTFGELKSRGQR 701
            .:|     .|..:|..:....:...|:::                 ||:.|....:..|..:  .
Human   445 YLL-----ASQAVDKCQSREGVDIALNDI-----------------ATFLGTVKEYPLLSPK--E 485

  Fly   702 FINLKIVDPYLETKSSAQAVQETLND----FSKRQVDV-----------------TSSLENWTTS 745
            |.|...:...|:.|:.||.|.:.|:|    |.||||.:                 ..|...|.:|
Human   486 FYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSS 550

  Fly   746 IAEKREVEYLLEKVMSDNEETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVIQDIERAQ 810
            ...:......|.:.:..:||...: |:::::      .:..|..:..:.:.|...:   ..||..
Human   551 KTSQPSTSVPLARPLRTSEEPYTE-TELNSR------GKEDDETKFEVKSEEIFES---HHERGN 605

  Fly   811 DEIQQRIQTTLGIQTKDQPSLAKIEQVINNL--------RMLKAKLDG----------------- 850
            .|::|  |..||       .|:...::|.:|        :.:|:.:||                 
Human   606 PELEQ--QARLG-------DLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDV 661

  Fly   851 ---------------IKYDYRTLVESVIQFLEN-------IVQLRREIDDYFARQQKEPASGADR 893
                           .::..||.::.:.:..||       .::.:.::..||...:..|.:   |
Human   662 LQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRA---R 723

  Fly   894 SIAEHEKFRDQCMDKFRSLITQSEL--LIDRVRVLEPPGAREIDTDRILKLLENLRLHFES---- 952
            :|.:      :|.|.....:.|.:|  .:...:.|:.|..|.|....:||.|    |.|||    
Human   724 AIWQ------ECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGL----LDFESPEDM 778

  Fly   953 -------NSSAR------------------MSTLERLEKIEQFRSDLEDIDRSLDSVSQ------ 986
                   ..||:                  ::.:|.|.|..:...||..:....|.:.:      
Human   779 EIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLL 843

  Fly   987 -------QLHEINNQSVDSLAAAKTTSLAFEYFERTIECSMPRQLKSTRHQRRWGQTAH-----T 1039
                   .:|: :...:..|...|.:......|||.|.....|.....:     |.:.|     |
Human   844 HGPFSVWTIHK-DRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQ-----GLSPHYSFKKT 902

  Fly  1040 IELLEKRIEKFTESTSQQLFITNPES-ERYVKDELRK-LNEKWQS--FKDQVKQKRKSLNQATDF 1100
            ::|:...|.:....:.::..|.:... |:|:.....| :.:.|.|  .|..::|:....:|....
Human   903 MKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQ 967

  Fly  1101 FEVVEKIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDIENYVTSREAALR------------ 1153
            ||:                |.|.     .....:|..:.::|...||:|....            
Human   968 FEM----------------STSK-----GSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSRE 1011

  Fly  1154 -SKLDSASQC--AHDMNKVSSLYNDVMNIFQS------------FIKLKMDINVVQERLKQEQRQ 1203
             |.:|:...|  |.||.|.||..: :..:|||            |:          ||.:..|.:
Human  1012 FSSMDTFEDCEGAEDMEKESSALS-LAGLFQSDDSHETCSSKSAFL----------ERGESSQGE 1065

  Fly  1204 KEQR--ERDARDQAEREKA 1220
            ||:|  |..|....|.|:|
Human  1066 KEERDEEETATRSTEEERA 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zorminNP_001261317.1 SPEC 126..332 CDD:238103 5/19 (26%)
SPEC <504..641 CDD:413338 37/190 (19%)
SMC_prok_B 654..>1389 CDD:274008 128/717 (18%)
Smc <1192..>1377 CDD:440809 11/31 (35%)
I-set 1390..1479 CDD:400151
Ig strand B 1407..1411 CDD:409564
Ig strand C 1420..1424 CDD:409564
Ig strand E 1445..1449 CDD:409564
Ig strand F 1459..1464 CDD:409564
Ig strand G 1472..1475 CDD:409564
I-set 1491..1580 CDD:400151
Ig strand B 1508..1512 CDD:409353
Ig strand C 1521..1525 CDD:409353
Ig strand E 1546..1550 CDD:409353
Ig strand F 1560..1565 CDD:409353
Ig strand G 1573..1576 CDD:409353
I-set 1589..1675 CDD:400151
Ig strand B 1606..1610 CDD:409353
Ig strand C 1619..1623 CDD:409353
Ig strand E 1641..1645 CDD:409353
Ig strand F 1655..1660 CDD:409353
Ig strand G 1668..1671 CDD:409353
I-set 1702..1786 CDD:400151
Ig strand B 1714..1718 CDD:409353
Ig strand C 1727..1731 CDD:409353
Ig strand E 1752..1756 CDD:409353
Ig strand F 1766..1771 CDD:409353
Ig strand G 1779..1782 CDD:409353
I-set 1811..1902 CDD:400151
Ig strand B 1828..1832 CDD:409353
Ig strand C 1841..1845 CDD:409353
Ig strand E 1868..1872 CDD:409353
Ig strand F 1882..1887 CDD:409353
I-set 1927..2015 CDD:400151
Ig strand B 1944..1948 CDD:409353
Ig strand C 1957..1961 CDD:409353
Ig strand E 1981..1985 CDD:409353
Ig strand F 1995..2000 CDD:409353
Ig strand G 2008..2011 CDD:409353
Ig 2142..2231 CDD:472250
Ig strand B 2159..2163 CDD:409353
Ig strand C 2172..2176 CDD:409353
Ig strand E 2197..2201 CDD:409353
Ig strand F 2211..2216 CDD:409353
Ig strand G 2224..2227 CDD:409353
I-set 2238..2325 CDD:400151
Ig strand B 2255..2259 CDD:409353
Ig strand C 2268..2272 CDD:409353
Ig strand F 2309..2314 CDD:409353
PHA03247 <2593..2893 CDD:223021
I-set 3566..3655 CDD:400151
Ig strand B 3583..3587 CDD:409353
Ig strand C 3596..3600 CDD:409353
Ig strand E 3621..3625 CDD:409353
Ig strand F 3635..3640 CDD:409353
Ig strand G 3648..3651 CDD:409353
MCF2L2NP_055893.4 SEC14 52..190 CDD:214706 23/110 (21%)
SPEC 321..523 CDD:238103 43/228 (19%)
Spectrin 323..428 18/105 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..614 14/95 (15%)
RhoGEF 623..820 CDD:214619 34/209 (16%)
PH-like 827..956 CDD:473070 21/134 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..1114 34/155 (22%)
Blue background indicates that the domain is not in the aligned region.

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