DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and Mcf2l

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_001357978.1	Gene:	Mcf2l / 17207	MGIID:	103263	Length:	1178	Species:	Mus musculus

Alignment Length:	1227	Identity:	238/1227 - (19%)
Similarity:	414/1227 - (33%)	Gaps:	423/1227 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 DEFVQKADKLLASK-------RISSELVNAMADTLNIIWQDILNLLQDRQHLLILCTQFHDKMTQ 220
            |||..|...::.|.       ...|:|...:..||            |..|...||   |....:
Mouse   156 DEFKMKVPVMMLSSVPELHGYIDKSQLTEDLGGTL------------DYCHSRWLC---HRTAIE 205

  Fly   221 CFRKMDQ----------LELACEETLHPPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQ 275
            .|..|.:          .|||  ||..|.||......|:...:.:..:...:..|||:||.:|..
Mouse   206 SFALMVKQTAQMLQAFGTELA--ETELPNDVQSTSLVLSAHTEKKAKVKEDLQLALKEGNSILES 268

  Fly   276 LEE-LEKLETLDTRPEHIKRDATRAVHQVQQWLEALHDRRNSLELAWQTRKIQMEQCL------- 332
            |.| |.:........:.:...||     ||:.|..|::...:.:..|...:.::||||
Mouse   269 LREPLAESAAHSVNQDQLDNQAT-----VQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQ 328

  Fly   333 ------------------------ALALLGRELVDLEA-------ALQQAR------MEL--NTM 358
                                    :||.:...|.||.|       |:.:||      .:|  |..
Mouse   329 GFREVKTTLDSMSQKIAAFTDVGNSLAHVQHLLKDLTAFEEKSSVAVDKARALSLEGQQLIENRH 393

  Fly   359 YSLGE-----------CEHTANE------MLTKYRE----------WKQQALLL----------- 385
            |::..           |:|.|:|      :|:|..|          |..:.:.|
Mouse   394 YAVDSIHPKCEELQHLCDHFASEVTRRRGLLSKSLELHSLLETSMKWSDEGIFLLASQPVDKCQS 458

  Fly   386 ---RDRALK------ITRAKEKVQSAGHFTEEDACARAYAVLSGCTEHLDLVDQREHWLHQSREF 441
               .:.||:      .|.|:.|:|......:|..|.....:|    ||:..|.|::   ..:.|.
Mouse   459 QDGAEAALQEIEKFLETGAENKIQELNEIYKEYECILNQDLL----EHVQKVFQKQ---ESTEEM 516

  Fly   442 FAKAEHTVSVLEKLELELTS------------VKLPPHSPESYAMFSKVDRDVRNFTEE--PLRL 492
            |.:.:   :.|:||..:.|.            .|.|..||.|:       |...|.:.|  .||.
Mouse   517 FHRRQ---ASLKKLAAKQTRPVQPVAPRPEALTKSPSPSPGSW-------RSSENSSSEGNALRR 571

  Fly   493 GYGILDEVGRTQPETQGVKRVLDELENRKVYIQGICANSSEDQQKVQRALSEFLNHH--NELLAW 555
            |               ..:|...|:...:   ||..:::.|:::.:     ..|..|  ||||..
Mouse   572 G---------------PYRRAKSEMSEPR---QGRTSSTGEEEESL-----AILRRHVMNELLDT 613

  Fly   556 LRASGQHQLQQSVDMGGNLQQAKQFLLQHHELMQDLE-IKGELINLLLESIKVHLESLSPQERYD 619
            .||..:                        ||:..|| ...|:.|.|:    .||.|...|.:.:
Mouse   614 ERAYVE------------------------ELLCVLEGYAAEMDNPLM----AHLISTGLQNKKN 650

  Fly   620 V--DSKAESLHKHWIELKDLVLKRVDYVSLLIDFFELANELSSQLDNLQRQLQQTPDEHKLQFLQ 682
            :  .:..|..|.|         .|:           ...||.|.:|        .|:.....||
Mouse   651 ILFGNMEEIYHFH---------NRI-----------FLRELESCID--------CPELVGRCFL- 686

  Fly   683 ATWTGIASTFGELKSRGQRFINLKIVDPYLETKSSAQAVQETLNDF-----SKRQVDVTSSLENW 742
                             :|....:|.:.|.:.|..::::....:|.     .::::|...||::
Mouse   687 -----------------ERMEEFQIYEKYCQNKPRSESLWRQCSDCPFFQECQKKLDHKLSLDS- 733

  Fly   743 TTSIAEKREVEYLLEKVMSDNEETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVIQDIE 807
                       |||:.|                        |.:...|||:   :::....:..|
Mouse   734 -----------YLLKPV------------------------QRITKYQLLL---KEMLKYSKHCE 760

  Fly   808 RAQDEIQQRIQTTLGI--QTKDQPSLAKIEQVINNLRML-KAKLDG---IKYDYR---TLVESVI 863
            .|:| :|:.:.:.|||  ...|...|..|.....||..| |..:.|   :..|::   |.|:.:.
Mouse   761 GAED-LQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKKGHTKVKELA 824

  Fly   864 QFL---------ENIVQLRREIDDYFARQQKEPASGADRSI------------AEHEKF------ 901
            :|.         |..|...::.::.....:|.|:....:|:            .:.:||
Mouse   825 RFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMTAVGITENVKGDTKKFEIWYNA 889

  Fly   902 RDQC--------------MDKFRSLITQSELLIDRVRVLEPPGAREIDTDRILKLLENLRLHFES 952
            |::.              :::.|.::| |:|          ...||....|.|:...:|.|...|
Mouse   890 REEVYIIQAPTPEIKAAWVNEIRKVLT-SQL----------QACREASQHRALEQSHSLPLPTPS 943

  Fly   953 NSSARMSTLERLEKIEQFRSDLEDIDRSLDS-VSQQLHEINNQSVDSLAAAKTT-SLAFEYFERT 1015
            ::|........::|:|..::|    ..||:. ||..|.:...:..|....:.|: |.|......|
Mouse   944 STSPTKGNTRNVKKLEDRKTD----PLSLEGYVSSSLPKPPEKGKDDAVPSSTSESSALSRKRFT 1004

  Fly  1016 IE--------CSMPRQLKSTRHQ----------RRWGQTAHTIELLEKRIEKFTESTSQQLFITN 1062
            ::        .:.|.: |:.||:          |.|.:|:|::|..|   |....|::::|..::
Mouse  1005 LQGLANLKASPTSPDK-KAKRHEVKSDPTPFGLRGWSKTSHSLEAPE---EDGGWSSAEELINSS 1065

  Fly  1063 PESERYVKDELRKLNEKWQSFKDQVKQKRKSL-NQATDFFEVVEKIDAEYREISYFYTSVSNKVP 1126
            ...|.......:.:..|:....|..|....:| .::.|..||||: .||             .:.
Mouse  1066 DAEEDGGVGPKKLVPGKYTVVMDDEKGGPDTLAMRSGDMVEVVEE-GAE-------------GLW 1116

  Fly  1127 YLRDSVEAGNLVNDIENYVTSREAALRSKLDSASQCAHDMNKVSSLYNDVMNIFQSF 1183
            |:||      |.:..|.:|.:...:......|::||....:  ||..:.|::...||
Mouse  1117 YVRD------LTSSKEGWVPASSLSTLLGKSSSAQCLSSSD--SSPGSAVLSSSSSF 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103	43/186 (23%)
		SPEC	<504..641	CDD:295325	27/141 (19%)
		COG1340	960..1298	CDD:224259	52/245 (21%)
		RILP-like	<1190..1315	CDD:304877
		MAP7	1233..1365	CDD:283355
		I-set	1390..1479	CDD:254352
		IGc2	1403..1469	CDD:197706
		I-set	1491..1580	CDD:254352
		IGc2	1504..1570	CDD:197706
		I-set	1589..1675	CDD:254352
		Ig	1605..1675	CDD:299845
		I-set	1702..1786	CDD:254352
		Ig	1713..1786	CDD:299845
		I-set	1811..1902	CDD:254352
		Ig	1828..1892	CDD:143165
		I-set	1927..2015	CDD:254352
		IGc2	1940..2005	CDD:197706
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Mcf2l	NP_001357978.1	SEC14	46..191	CDD:214706	9/46 (20%)
		SPEC	322..524	CDD:238103	36/211 (17%)
		RhoGEF	603..780	CDD:238091	52/290 (18%)
		PH_Dbs	787..918	CDD:269934	20/131 (15%)
		SH3_DBS	1082..1136	CDD:212791	17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900