DRSC/TRiP Functional Genomics Resources

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Protein Alignment zormin and PLEKHG4B

DIOPT Version :9

Sequence 1:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster
Sequence 2:NP_443141.4 Gene:PLEKHG4B / 153478 HGNCID:29399 Length:1627 Species:Homo sapiens


Alignment Length:1201 Identity:227/1201 - (18%)
Similarity:359/1201 - (29%) Gaps:433/1201 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  2380 EVTSANDLHGLSESKVITEHRCTTEATMRLEHKSNYLDLPEL-------------TTRPKTPTTN 2431
            :||||    |...::::.  :|.:    ||...:..:.:||.             ..|.:.....
Human   122 QVTSA----GKQSARLVL--KCLS----RLGRGTEEVTVPEAMYGCVFTGAFLEWVNRERRHVPL 176

  Fly  2432 DTITITTNTATVSMDQPDLTQPTI---------TNTTTTNTTKVP--PPVPPKPCTPVVATTFGQ 2485
            .|..:|:..|.......|:|.|..         :.::.|...::|  |...|.| |...|....|
Human   177 QTCLLTSGLAVHRAPWSDVTDPVFVPSPGAILQSYSSCTGPERLPSSPSEAPVP-TQATAGPHFQ 240

  Fly  2486 QQQQPPQTLTS------TRYEQSEH-----------KSTTSSSSFDYFKKI-------------- 2519
            .....|.||||      |..:|..|           ..|.|.||...|:|:              
Human   241 GSASCPDTLTSPCRRGHTGSDQLRHLPYPERAELGSPRTLSGSSDRDFEKVSPSEQGPRMPPENC 305

  Fly  2520 ----------DEETIIQRPNPLTF------------KPLDTVVRQPQ---AQSLAEELRSLNLIP 2559
                      |:|   .||..|||            .|.|....||:   .:|..|.||  |.:|
Human   306 GGSGERPDPMDQE---DRPKALTFHTDLGIPSSRRRPPGDPTCVQPRRWFRESYMEALR--NPMP 365

  Fly  2560 -GDAPE-----FCYS----------------PKTERSEPK-----IPLITEKIKILSEVQP---- 2593
             |.:.|     .|.|                .:.|.|.|:     .|.:.::....|...|    
Human   366 LGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAG 430

  Fly  2594 -----------KEPPPQGGVPVFPPPLGLQTVQHES-------------TTTKEVKVEYGQPIVR 2634
                       :.|....|...    ....|..|.:             .|...|.|| |....:
Human   431 RTLPRRSRSWERAPRSSRGAQA----AACHTSHHSAGSRPGGHLGGQAVGTPNCVPVE-GPGCTK 490

  Fly  2635 PAAVLATPA----------QQNPRSPS------PKPSAEGVAMSRLWTPTGVTGYTSDVEQK--- 2680
            ...|||:.|          ..||..||      |.|..||      | |.|...:.|.|.::   
Human   491 EEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEG------W-PPGTGDFPSQVPKQVLD 548

  Fly  2681 -SEKTVISKLATPTPTKELNAPFLVNQIAKSIPPTTAPVTHLVNVELEPGTPPEICFAPKVEETR 2744
             |::.:.|.:.|...|::.:...:|                                     :.|
Human   549 VSQELLQSGVVTLPGTRDRHGRAVV-------------------------------------QVR 576

  Fly  2745 RRSLVETMEQKLEQNLIQGPSKVLP--HSVPTLTPNTAAPVQPKPLG-----NTTYRPPPPVLPT 2802
            .|||:.|.|......|    :::|.  ||:|.        .:.:.||     :....|..|.:..
Human   577 TRSLLWTREHSSCAEL----TRLLLYFHSIPR--------KEVRDLGLVVLVDARRSPAAPAVSQ 629

  Fly  2803 RLGVYESDYESDRYKYSGSESDVEPGIRKQPQLTTMETSFKSSGYTADTEEHSSYRKSESSFYET 2867
            .|              ||.:::..|.|.....|...|::|:.........|..|..|:...|.::
Human   630 AL--------------SGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDS 680

  Fly  2868 KSSSTMGGAPQLQTQFP-----------KLQPEPPAPIYFTAKPQPQVPPQVPPSQSNVSSQEAK 2921
            ...:.     .|...||           :|:       :|.|                 :.:|| 
Human   681 CQLTA-----DLDGSFPYSHGDWICFRQRLE-------HFAA-----------------NCEEA- 715

  Fly  2922 GYKYTSSSMTSNYSHNMQSSSSS-----SHHETKFSSTSAPPPVVTY---PSPIPAQ-------- 2970
             ..:..:|..|..:|....::..     ..|||........|.:|:.   ...:.|:        
Human   716 -IIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREELGT 779

  Fly  2971 ---RKTPAAEFSDYSSEIDERFRSVSRANESDAEIKGYRVVFPPTPTPRTNIATNGHKS---PVV 3029
               |.|..|..|.|....:|..|.|..:|....:::..|.:       .:.:..|..:|   .:.
Human   780 EDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLREL-------ASLLEGNDQQSCQKGLQ 837

  Fly  3030 VITPSPMEFEPTPQDYARPKFEPISK-EIRH-EIKTETSSKQ-----SKFMQNQQQNQPVFKPKP 3087
            :...:|...|...||:.|.....:|: |.|. |:...|.|.:     |.:|   ....|...|..
Human   838 LAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWM---GPLDPEACPSS 899

  Fly  3088 VAAKFIAATQQQQQKQPQATSRPTMYYNAVAGAPMHVAKVATETKNVMQMHESTE--SSQRVVNM 3150
            ..|:.:.:..|      :|||        ||......|.||     |::.|...:  :||:.:.:
Human   900 PVAECLRSCHQ------EATS--------VAAEAFPGAGVA-----VLKPHALGKPWASQQDLWL 945

  Fly  3151 Q--QTKRIIHFDSPQEQRDQQILEPFPYSP---ATSRTPSRQSHLPP-------------PATPT 3197
            |  ||:..:. ::..|......|.|...||   ..::...|:...||             ||.|.
Human   946 QYPQTRLRLE-EALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPL 1009

  Fly  3198 KFVPGEFRESDYESEIDGARIQP----LWSPY-------GDG----------------------- 3228
            ..:||.......    ||..::|    ||.|.       |.|                       
Human  1010 SGLPGRALLCGQ----DGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASR 1070

  Fly  3229 -----------MTKGFRRVAPPQGAGRSCSLPRTYERVLSPMEFDRGPEMPSKIHVDINTLRKEQ 3282
                       .|:.|....|..|...||....|       ..|.:|.|:.|.:..: ..|...|
Human  1071 PRKHPQKKMIKKTQSFEIPQPDSGPRDSCQPDHT-------SVFSKGLEVTSTVATE-KKLPLWQ 1127

  Fly  3283 RGGSTVTTQNRTQSLNRNTTMRQQQQQQQQQ 3313
            ...|...||:|  ||:..:.:...::..:||
Human  1128 HARSPPVTQSR--SLSSPSGLHPAEEDGRQQ 1156

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zorminNP_001261317.1 SPEC 126..332 CDD:238103
SPEC <504..641 CDD:295325
COG1340 960..1298 CDD:224259
RILP-like <1190..1315 CDD:304877
MAP7 1233..1365 CDD:283355
I-set 1390..1479 CDD:254352
IGc2 1403..1469 CDD:197706
I-set 1491..1580 CDD:254352
IGc2 1504..1570 CDD:197706
I-set 1589..1675 CDD:254352
Ig 1605..1675 CDD:299845
I-set 1702..1786 CDD:254352
Ig 1713..1786 CDD:299845
I-set 1811..1902 CDD:254352
Ig 1828..1892 CDD:143165
I-set 1927..2015 CDD:254352
IGc2 1940..2005 CDD:197706
I-set 2142..2231 CDD:254352
Ig 2158..2231 CDD:299845
I-set 2238..2325 CDD:254352
Ig 2254..2324 CDD:299845
I-set 3566..3655 CDD:254352
Ig 3583..3650 CDD:143165
PLEKHG4BNP_443141.4 Herpes_ICP4_C 186..>468 CDD:332854 57/291 (20%)
RhoGEF 1165..1308 CDD:306973
PH_puratrophin-1 1332..1467 CDD:270062
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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