DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and MUCL3

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_543146.2	Gene:	MUCL3 / 135656	HGNCID:	21666	Length:	1393	Species:	Homo sapiens

Alignment Length:	1482	Identity:	296/1482 - (19%)
Similarity:	480/1482 - (32%)	Gaps:	445/1482 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1965 QPVHGHNFLVSTSGERQVLTIQKLTHDAVGKISCVAENEAGKATCVAFLNIR-GSGLPASSDVQT 2028
            ||||.   |.|..|                 :.|          |:.||... |:|       .|
Human     3 QPVHS---LCSAFG-----------------LQC----------CLLFLLASWGAG-------AT 30

  Fly  2029 VSQEHNTESSRVTIKKQTFTTTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESH- 2092
            ..||:.                .|.::::.:...|.|.....|...|..:...||:.||:.:|.
Human    31 TFQEYQ----------------KTGELSTSDHIFPLTPGLVYSIPFDHIVLHSGQRPPELPKSTE 79

  Fly  2093 -HYQELH-----KSKEMSSPTVQQKSFSFIQSSGANGQ--------SAVAIPDSPTRLRREIAPR 2143
             |.|:.|     .||....||...|:... :||..|.:        |:....|...|.:|.:.|.
Human    80 IHEQKRHCNTTRHSKPTDKPTGNSKTIDH-KSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPA 143

  Fly  2144 FTTPL----SGKIVDQGADVSMEAIYDGFPSPEIKVEKNGGQLFEDAHTRISNKCNRVTIELKQV 2204
            .:|..    :||     ..::        |:|:.|:........:...||.|:|..| .:| |.:
Human   144 DSTTTHKESAGK-----KHIT--------PAPKSKINCRKSTTGKSTVTRKSDKTGR-PLE-KSM 193

  Fly  2205 GVGDAGRYAVTASNTVGQSTSTADLVVKKTIFPPVFGRRLQAQVSKKGEKLT----MEVEVTGLP 2265
            ...|....:...:.|...::..:....|.|.||               ||:|    ...:.||.|
Human   194 STLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFP---------------EKITAASKTTYKTTGTP 243

  Fly  2266 EPTVTWLKDDKPLKDA--GISEHRLLAQGNSYRLIIEKAQTTDSGKYMVRATNAGGEAKSIADCA 2328
            |       :.:..:|:  .::..:||.:  :.:.|.|.....:..:.:...|..||...:..:
Human   244 E-------ESEKTEDSRTTVASDKLLTK--TTKNIQETISANELTQSLAEPTEHGGRTANENN-- 297

  Fly  2329 ILEPSPERLQEVVKTIVYETGPVAPASEFKTEVQKQIQNSENQQSYQNSQTEVTSANDLHGLSES 2393
              .|||....|..:....|...::||...           ||::...|..|....|    |.:|:
Human   298 --TPSPAEPTENRERTANENTTLSPAEPI-----------ENRERTANENTAPFPA----GPTEN 345

  Fly  2394 KVITEHRCTTEATMRLEHKSNYLDLPELTTRPKTPTTNDTITITTNTATVSMDQPDLTQPTITNT 2458
            :.:|.:..|                   |..|..||.:...|...||.      |...:||....
Human   346 REMTANENT-------------------TLFPAEPTEHGERTANENTT------PSPAEPTEHGE 385

  Fly  2459 TTTNTTKVPPPVPPKPCTPVVATTFGQQQQQPPQTLTSTRYEQSEHKSTTSSSSFDYFKKIDEET 2523
            .|.|....|.|..|        |..|::........||:..|.:||...|..:        :|.|
Human   386 RTANENTTPSPAEP--------TEHGERTPFANDKTTSSSAESTEHGERTPLA--------NENT 434

  Fly  2524 IIQRPNPLTFKPLDTVVRQPQAQSLAEELRSLNLIPGDAPEFCYSPKTERSEPKIPLITEKIKIL 2588
               .|:|.  :|.:.          .|...:.|..|..|     .| ||..|   ....|| ..|
Human   435 ---TPSPA--EPTEN----------RERTANENTTPSPA-----GP-TENRE---TTANEK-TTL 474

  Fly  2589 SEVQPKEPPPQGGVPVFPPPLGLQTVQHESTTTKEVK-VEYGQPIVRPAAVLATP-AQQNPRSPS 2651
            |.|:|.|              ..:|..:|.||....: .|.||         .|| |.:...|.|
Human   475 SPVEPTE--------------NRETTANEKTTPSPAEPTENGQ---------RTPFANEKTTSSS 516

  Fly  2652 PKPSAEGVAMSRLWTP---TGVTGYTSDVEQKSEKTVISKLATPT---PTKELNAPFLVNQIAKS 2710
            .:|:..|..     ||   ...|...::..:..|:|...| .||:   ||:..:...|.|:  |:
Human   517 AEPTEHGER-----TPLANENTTPSPAEPTENRERTANEK-TTPSPAEPTENGDRTPLANE--KT 573

  Fly  2711 IPPTTAPVTHLVNVELEPG--TPPEICFAPKVEETRRRSLVETMEQK----LEQNLIQGPSKVLP 2769
            .|....|.        |.|  ||    ||.  |:|...|...|..::    ..:|....|::...
Human   574 TPSLAEPT--------ENGQRTP----FAN--EKTTSSSAEPTEHEERTPLANENTTPSPAEPTE 624

  Fly  2770 HSVPTLTPNTAAPVQPKPLGNTTYRPPPPVLPTRLGVYESDYESDRYKYSGSESDVEPGIRKQPQ 2834
            :...|...||.    |.|.|.|..|.......|.|  :.::...:|.:.:..::...|.   :|.
Human   625 NRERTANENTT----PSPAGPTENREMTANEKTTL--FPAEPTENRERTANEKTTSSPA---EPT 680

  Fly  2835 LTTMETSF---KSSGYTADTEEHSSYRKSESSFYETKSSSTMGGAP---------QLQTQFPKLQ 2887
            .....|.|   |::..:|:..||     .|.:....::::.....|         :..|.||
Human   681 ENGQRTPFANEKTTSSSAEPTEH-----GERTPLANENTTLSPAEPTENRERTANEKTTPFP--- 737

  Fly  2888 PEP-------------PAPIYFTAKP-----------QPQVPPQVPPSQSNVSSQEAKGYKYTSS 2928
            .||             |:|    |:|           :...|....|:::...:..|.....:||
Human   738 AEPTENRERTANENTTPSP----AQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSS 798

  Fly  2929 SMTSNYSHNM----QSSSSSSHHETKFSSTSAPPPVVTYP---------------SPIPAQ---- 2970
            :..:.::...    ::::||....|:....:|......:|               :|.||:
Human   799 AEPTEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTEN 863

  Fly  2971 RKTPAAEFSDYS-SEIDERFRSVSRANESDAEIKGYRVVFPPTPTPRTNIATNGHKSPVVVITPS 3034
            |:..|.|.:..| :|..|.......|||.       ..:.|..||      .||.::|......:
Human   864 REWTANENTTLSPAEPTEHEEMTPLANEK-------TTLSPAEPT------ENGERTPFTNEKTT 915

  Fly  3035 PMEFEPTPQDYARPKFEPISKEIRHEIKTETSSKQSKFMQNQQQNQPVFKPKPVAAKFIAATQQQ 3099
            |...|||...    :..|::.||....:.| .::..:.:.|::..     |.|........|...
Human   916 PSSAEPTEHG----ERTPLANEITTPSRAE-PTEHGERIANEKAT-----PSPAKPTEHGETTVN 970

  Fly  3100 QQKQPQATSRPTMYYNAVAGAPMHVAKVATETKNVMQMHESTESSQRVVNMQQTKRIIHFDSPQE 3164
            :...| :::.||     ..|....:|...|.|...    ||||..:|..|.:.|
Human   971 EDTTP-SSAEPT-----ENGERTPLANENTTTSPT----ESTEHGERTANEKTT----------- 1014

  Fly  3165 QRDQQILEPFPYSPAT--SRTPS-RQSHLPPPATPTKF-----------VPGEFRESDYESEIDG 3215
                    |.|..|..  .|||| .:..:|.||.||:.           .|...:.:::..:...
Human  1015 --------PSPAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTL 1071

  Fly  3216 ARIQPLWSP-----YGDGMTKGFRRVAP----PQGAGRSCSLPR-----------------TYER 3254
            |..:...||     :|...|....::.|    |...|...:.|.                 |...
Human  1072 ANEKITLSPEGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSAN 1136

  Fly  3255 VLSPMEFDRGPEMPSKIHVDINTLRKEQRGGSTVTTQNRTQSLNRNTTMRQQ 3306
            |::|     .|..|.| |....||..|:   .|..|:..|:...:.|:..::
Human  1137 VITP-----APAEPIK-HAKRTTLAHEK---MTQVTEKSTEHPEKTTSTTEK 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259
		RILP-like	<1190..1315	CDD:304877
		MAP7	1233..1365	CDD:283355
		I-set	1390..1479	CDD:254352
		IGc2	1403..1469	CDD:197706
		I-set	1491..1580	CDD:254352
		IGc2	1504..1570	CDD:197706
		I-set	1589..1675	CDD:254352
		Ig	1605..1675	CDD:299845
		I-set	1702..1786	CDD:254352
		Ig	1713..1786	CDD:299845
		I-set	1811..1902	CDD:254352
		Ig	1828..1892	CDD:143165
		I-set	1927..2015	CDD:254352	11/49 (22%)
		IGc2	1940..2005	CDD:197706	8/39 (21%)
		I-set	2142..2231	CDD:254352	16/92 (17%)
		Ig	2158..2231	CDD:299845	12/72 (17%)
		I-set	2238..2325	CDD:254352	15/92 (16%)
		Ig	2254..2324	CDD:299845	14/75 (19%)
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
MUCL3	NP_543146.2	Atrophin-1	<299..820	CDD:331285	137/667 (21%)
MUCL3	NP_543146.2	LGT	<916..1062	CDD:320995	39/184 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900