DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zormin and Mylk

DIOPT Version :9

Sequence 1:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster
Sequence 2:	NP_647461.3	Gene:	Mylk / 107589	MGIID:	894806	Length:	1950	Species:	Mus musculus

Alignment Length:	2530	Identity:	477/2530 - (18%)
Similarity:	768/2530 - (30%)	Gaps:	891/2530 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1389 SPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFD---KGICRLVIE 1450
            :|.|..|.::...:||....||..|.|.|||.|.|.:.|.:| ||.. :...|   :|...|||.
Mouse    41 APAFILPPRNLCVKEGATAKFEGRVRGYPEPQVTWHRKGQAI-TNGG-RFLLDCGVRGTFSLVIH 103

  Fly  1451 ETFAADSARFSCRASNLVGTCDTNATLSVRENAAEVQ---------------------LVPPRIL 1494
            .....|..:::|.|||..|.......|:|..|:.:.:                     ..||:..
Mouse   104 TVREEDKGKYTCEASNGSGARQVTVELTVEGNSMKKRDQPVLSKASGFPGETRPSIWGECPPKFA 168

  Fly  1495 RFLQSGKATEGSSFQFACVVAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVFLEDDA 1559
            ..|......||...:|:|.:.|.|.|.|.|.|.:..:..|....:|..||...|:...|..:|..
Mouse   169 TKLGRAVVKEGQMGRFSCKITGRPPPQVTWLKGNVPLQPSARVSMSEKNGMQILEIRGVTRDDLG 233

  Fly  1560 VYTCSASNPAGIEHCSASLIVEPLE--------PTELPS--FKVPLSNAMARVGQKIKLEAIVGG 1614
            ||||...|.:|....||.|.:..|:        .|:.||  .:..::|.:::..:.:   |....
Mouse   234 VYTCMVVNGSGKASMSAELSIPGLDNAARLAVRGTKAPSPDIRKEVTNGVSKDPETV---AESKN 295

  Fly  1615 IPRPE-------VYWLHNGKPFQPRDSKYE---------------YGRVTL----IIPQAYPNDA 1653
            .|.|:       ....|...|.:|:....|               ...:||    :.|:|.....
Mouse   296 CPSPQRSGSSARATNSHLKSPQEPKPKLCEDAPRKVPQSSILQKSTSTITLQALKVQPEARVPAI 360

  Fly  1654 GSYV--LSAKNLAGEAYTSC------------NVIVKGRLPNETSDSEMASDIEPIKPAVHLPLK 1704
            ||:.  ...|:||.....:.            |..|.|.:|.|       |..|...|......:
Mouse   361 GSFSPGEDRKSLAAPQQATLPTRQSSLGGSVGNKFVTGNIPRE-------SQRESTFPRFESQPQ 418

  Fly  1705 DVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLLFQ-GDRCSLIIQEVYQEDAGHYK 1768
            ...:.||:.|:..|.:.|.|:|:|.|:....||:....:..::: |....|.:......|:|.|.
Mouse   419 SQEVTEGQTVKFICEVSGIPKPDVGWFLEGIPVRRREGITEVYEDGVSHHLCLLRARTRDSGRYS 483

  Fly  1769 VVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFERLLSDVLADEGEQVVLEVQ 1833
            ..|.||.|:.|.|..|.|...|.|:.|               |.|..:|.|.:..||:..||
Mouse   484 CTASNSLGQVSCSWSLLVDRPNLAQTA---------------PSFSSVLKDSVVIEGQDFVL--- 530

  Fly  1834 ASGDQPLTAQWFLTNKELQLDQRITTQSDSELGVFKLILNNVSGDDKGVYTVKVTNPAGDAKCFS 1898

Mouse   531 ----------------------------------------------------------------- 530

  Fly  1899 HLIVKSVNAPENRRSSQSSVEIIERHQCPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHWFFN 1963
                                                            .|.|:|.|.|:|.|..|
Mouse   531 ------------------------------------------------RCSVQGTPAPRVTWLLN 547

  Fly  1964 DQPVH-GHNFLVSTSGERQVLTIQKLTHDAVGKISCVAENEAGKATCVAFLNIRGSGLPASSDVQ 2027
            .||:. .|:...:...|   |.||....:..|..:|:|||..|:.:|.|.:.:
Mouse   548 GQPIQFAHSICEAGVAE---LHIQDALPEDRGTYTCLAENAMGQVSCSATVTV------------ 597

  Fly  2028 TVSQEHNTESSRVTIKKQTFTTTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESH 2092
               ||...|..|                                                   .|
Mouse   598 ---QEKKGEGER---------------------------------------------------EH 608

  Fly  2093 HYQELHKSKEMSSPTVQQKSFSFIQSSGANGQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQGA 2157
            ..                                     ||.| .:.|||.|...||...|..|:
Mouse   609 RL-------------------------------------SPAR-SKPIAPIFLQGLSDLKVMDGS 635

  Fly  2158 DVSMEAIYDGFPSPEIKVEKNGGQLFEDAHTRISNKCNRVTIELKQVGVGDAGRYAVTASNTVGQ 2222
            .|:|.....|.|.||:....:|.::.|........|....::.:::|...|.|.|...|.|:.|:
Mouse   636 QVTMTVQVSGNPPPEVIWLHDGNEIQESEDFHFEQKGGWHSLCIQEVFPEDTGTYTCEAWNSAGE 700

  Fly  2223 STSTADLVVKKTIFP-----PVFGRRLQAQVSKKGEKLTMEVEVTGLPEPTVTWLKDDKPL-KDA 2281
            ..:.|.|.|::   |     |.|..:.::..:..|:.:.:...:.|.|.|||.||:|.:.| ||:
Mouse   701 VRTRAVLTVQE---PHDGTQPWFISKPRSVTATLGQSVLISCAIAGDPFPTVHWLRDGRALSKDS 762

  Fly  2282 GISEHRLLAQGNSYRLIIEKAQTTDSGKYMVRATNAGGEAKSIADCAI---LEPSPERLQEVVKT 2343
            |..|  ||...:.:.|:::..|...:|:|.:...|..||    ..|.:   |..||.|.....:.
Mouse   763 GHFE--LLQNEDVFTLVLKNVQPWHAGQYEILLKNRVGE----CSCQVSLMLHNSPSRAPPRGRE 821

  Fly  2344 IVYETG--------------------PVAPASEFKTEVQKQIQNSENQQSYQNSQTEVTSANDLH 2388
            .....|                    |..||               ..|.:    .|.....|:.
Mouse   822 PASCEGLCGGGGVGAHGDGDRHGTLRPCWPA---------------RGQGW----PEEEDGEDVR 867

  Fly  2389 GLSESKVITEHRCTTEATMRLEHKSNYLDLPELTTR---PKTPTTNDTITI-------------T 2437
            ||.:.:|  |.|..||..:| :.:...||..:|..:   .||.:.:|...|             .
Mouse   868 GLLKRRV--ETRLHTEEAIR-QQEVGQLDFRDLLGKKVSTKTVSEDDLKDIPAEQMDFRANLQRQ 929

  Fly  2438 TNTATVSMDQPDLTQP------TITNTTTTNTTKVPPPVPPKPCTPVVATTFGQQQQQPPQT--- 2493
            ....|:|.::..:..|      ::.....|..|.||...|||..||...:..|.:::.|.:.
Mouse   930 VKPKTISEEERKVHSPQQVDFRSVLAKKGTPKTPVPEKAPPKAATPDFRSVLGGKKKSPSENGGN 994

  Fly  2494 ---LTSTRYEQSEHKSTTSSSSFDYFKKIDEETIIQRPNPL-TFKPLDTVVRQPQAQSLAEELRS 2554
               :.:.:..:|. .....:.:....|.:......:.|.|: ..||.:|:  :|...:...|  :
Mouse   995 SAEVLNVKAGESP-TPAGDAQAIGALKPVGNAKPAETPKPIGNAKPTETL--KPVGNTKPAE--T 1054

  Fly  2555 LNLIPGDAPEFCYSPKT--ERSEPKIPLIT------------EKIK-ILSEV-----------QP 2593
            |..|....|.....|.|  :.:||:.|:..            |::| :.::|           ..
Mouse  1055 LKPIANAQPSGSLKPVTNAQPAEPQKPVGNAKSAETSKPAGKEEVKEVKNDVNCKKGQVGATGNE 1119

  Fly  2594 KEPPPQGGVPVFPPPLGLQTVQHESTTTKEVKVEYGQPIVRPAAVLATPAQQNPRSPSPKPSAEG 2658
            |.|..||..|||...|            ::|.|..|:.::....|::.|    |.:.:
Mouse  1120 KRPESQGSAPVFKEKL------------QDVHVAEGEKLLLQCQVISDP----PATVT------- 1161

  Fly  2659 VAMSRLWTPTGVTGYTSD----VEQKSEKTVISKLATPTPTKELNAPFLVNQIAKSIPPTTAPVT 2719
                  |:..|.|..|:.    .::.|..:|..:.|.|....      |...:||:   :.....
Mouse  1162 ------WSLNGKTLKTTKFIVLAQEGSRFSVSIEKALPEDRG------LYKCVAKN---SAGQAE 1211

  Fly  2720 HLVNVELEPGTPPEICFAPKVEETRRRSLVETMEQKLEQNLIQGPSKVLPHSVPTLTPNTAAPVQ 2784
            ....|.::.....|...||:::..|                   |...||   |.|...:.|.|:
Mouse  1212 CSCQVTVDDAQTSENTKAPEMKSRR-------------------PKSSLP---PVLGTESDATVK 1254

  Fly  2785 PKPLGNTTYRPPPPVLPTRLGVYESDYE---SDRYKYSGSESDVEP------GIRKQPQLTTMET 2840
            .||...|   |....:|.::..:..|.:   .:..:..|..:..:|      ..|||.|
Mouse  1255 KKPAPKT---PTKAAMPPQIIQFPEDQKVRAGEPVELFGKVAGTQPITCKWMKFRKQIQ------ 1310

  Fly  2841 SFKSSGYTADTEEHSSYRKSESSFYETKSSSTMGGAPQ---------LQTQFPKLQPEPPAPIYF 2896
                      ..||......||.     |..|:..|.|         ::.:....|    |.:..
Mouse  1311 ----------ESEHIKVENGESG-----SKLTILAARQEHCGCYTLVVENKLGSRQ----AQVNL 1356

  Fly  2897 TAKPQPQVPPQVPPSQSNVSSQEAK----GYKYTSSSMTSNYSHNMQSSSSSSHHE-TKFSSTSA 2956
            |...:|. ||...|..|::.|....    |..|...|...:|:..:..:......| ....|||
Mouse  1357 TVVDKPD-PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYNVEIWDTEDKVWKELATCRSTS- 1419

  Fly  2957 PPPVVTYPSPIPAQRKTPAAEFSDYSSEIDERFRSVS------RANESDAEIKGYRVVFPPTPTP 3015
                      ...|...|..|:.       .|.|:|:      .:.||:....|.:   |..|..
Mouse  1420 ----------FNVQDLLPDREYK-------FRVRAVNVYGTSEPSQESELTAVGEK---PEEPKD 1464

  Fly  3016 RTNIATNGHKSPVVVITPSPMEFEPTPQDYARPKFEPISKEIRHEIKTETSSKQSKFMQNQQQNQ 3080
            ...::.:..|.|.|......:..|....|.             ::|:....|  .||.|
Mouse  1465 EVEVSDDDEKEPEVDYRTVTVNTEQKVSDV-------------YDIEERLGS--GKFGQ------ 1508

  Fly  3081 PVFK------PKPVAAKFIAATQQQQQKQPQATSRPTMYYNAVAGAPMHVAKVATETKNVMQMHE 3139
             ||:      .|..|.||..|                  |:            |.|..|:.|
Mouse  1509 -VFRLVEKKTGKIWAGKFFKA------------------YS------------AKEKDNIRQ--- 1539

  Fly  3140 STESSQRVVN-MQQTKRIIHFDSPQEQRD-QQILEPFPYSPATSRTPSRQSHLPPPATPTKFVPG 3202
              |.|  ::| :...|.:...|:.:|:.: ..:||                          .|.|
Mouse  1540 --EIS--IMNCLHHPKLVQCVDAFEEKANIVMVLE--------------------------IVSG 1574

  Fly  3203 -----EFRESDYESEIDGARIQPLWSPYGDGMTKGFRRVAPPQGAGRSCSLPRTYERVLSPMEFD 3262
                 ...:.|:|                  :|:            |.|.   .|.|.:|
Mouse  1575 GELFERIIDEDFE------------------LTE------------RECI---KYMRQIS----- 1601

  Fly  3263 RGPEMPSK---IHVDINTLRKEQRGGSTVTTQNRTQSLNRNTTMRQQQQQQQQQSMDQIDRAGTL 3324
            .|.|...|   :|:|:                                   :.:::..:::.||.
Mouse  1602 EGVEYIHKQGIVHLDL-----------------------------------KPENIMCVNKTGTR 1631

  Fly  3325 PRYGYSSLQQQAENQGRRMGSTFLQKSHQFVDDVSREIRSSASNGIRPGFKRAPSEGSSQQPQAF 3389
            .:.....|.::.||.|   ....|..:.:||                     || |..:.:|..:
Mouse  1632 IKLIDFGLARRLENAG---SLKVLFGTPEFV---------------------AP-EVINYEPIGY 1671

  Fly  3390 RDESRVSQYGTKCVDPNTGLIYF---------------KYDFGYEFGILFPGEGHKFVSS----- 3434
            ..:  :...|..|....:||..|               .:||..|.......:...|:|:
Mouse  1672 ATD--MWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKD 1734

  Fly  3435 -------------QWNSSGSSNSNAKPIQNGRHSPYPLKLPPGNELVIPVQHERSAQGYSSDNEV 3486
                         .|....:.|..||.:...|...|..:
Mouse  1735 MKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMAR-------------------------- 1773

  Fly  3487 QRRSQTRNWSTTKPMAPRTINSHKRYSLPSGHSLDIHLDRLHAQAPRLPPDQMIRTVPELPNTEP 3551
                  |.|..| ..|.|.|......::.||.|        ..::....|            |.|
Mouse  1774 ------RKWQKT-GNAVRAIGRLSSMAMISGLS--------GRKSSTGSP------------TSP 1811

  Fly  3552 VNAHL--SRDELAQR------------QPLFITPLKDIAVGVGGTARFECIVQAHPQPQVNWTHN 3602
            :||..  |.|:::|.            :|.|...::|:.|..|..|||:|.::.:|.|:|.|..:
Mouse  1812 INAEKLESEDDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKD 1876

  Fly  3603 GGLLESGSRHCIEY-RNGVCRLTLPQAYPDDNGSYACTAINPLGAATTSGNLTVSSTNRG 3661
            ...:.......|:| .:|.|.|.:.....||:..|.|.|:|.||.||.:..|.|.:...|
Mouse  1877 DQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEG 1936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259
		RILP-like	<1190..1315	CDD:304877
		MAP7	1233..1365	CDD:283355
		I-set	1390..1479	CDD:254352	30/91 (33%)
		IGc2	1403..1469	CDD:197706	25/68 (37%)
		I-set	1491..1580	CDD:254352	28/88 (32%)
		IGc2	1504..1570	CDD:197706	22/65 (34%)
		I-set	1589..1675	CDD:254352	20/127 (16%)
		Ig	1605..1675	CDD:299845	17/109 (16%)
		I-set	1702..1786	CDD:254352	23/84 (27%)
		Ig	1713..1786	CDD:299845	21/73 (29%)
		I-set	1811..1902	CDD:254352	8/90 (9%)
		Ig	1828..1892	CDD:143165	2/63 (3%)
		I-set	1927..2015	CDD:254352	23/88 (26%)
		IGc2	1940..2005	CDD:197706	20/65 (31%)
		I-set	2142..2231	CDD:254352	24/88 (27%)
		Ig	2158..2231	CDD:299845	18/72 (25%)
		I-set	2238..2325	CDD:254352	25/87 (29%)
		Ig	2254..2324	CDD:299845	22/70 (31%)
		I-set	3566..3655	CDD:254352	29/89 (33%)
		Ig	3583..3650	CDD:143165	23/67 (34%)
Mylk	NP_647461.3	I-set	42..132	CDD:254352	30/91 (33%)
		Ig	42..131	CDD:299845	29/90 (32%)
		I-set	165..254	CDD:254352	28/88 (32%)
		Ig	183..251	CDD:143165	22/67 (33%)
		23ISL	255..409	CDD:293226	28/163 (17%)
		I-set	411..501	CDD:254352	24/89 (27%)
		Ig	428..498	CDD:143165	20/69 (29%)
		I-set	511..597	CDD:254352	31/204 (15%)
		IGc2	524..587	CDD:197706	24/181 (13%)
		I-set	620..709	CDD:254352	24/88 (27%)
		Ig	637..706	CDD:143165	16/68 (24%)
		I-set	718..806	CDD:254352	26/93 (28%)
		Ig	721..806	CDD:299845	24/90 (27%)
		I-set	1129..1218	CDD:254352	22/126 (17%)
		IGc2	1142..1208	CDD:197706	15/91 (16%)
		Ig	1269..1366	CDD:299845	20/122 (16%)
		I-set	1269..1358	CDD:254352	17/113 (15%)
		FN3	1362..1453	CDD:238020	22/109 (20%)
		STKc_MLCK1	1492..1750	CDD:271093	64/442 (14%)
		Pkinase	1495..1750	CDD:278497	63/426 (15%)
		I-set	1840..1930	CDD:254352	29/89 (33%)
		IGc2	1853..1920	CDD:197706	20/66 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910