DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GNA15 and Galphaq

DIOPT Version :9

Sequence 1:	NP_002059.3	Gene:	GNA15 / 2769	HGNCID:	4383	Length:	374	Species:	Homo sapiens
Sequence 2:	NP_725192.2	Gene:	Galphaq / 36384	FlyBaseID:	FBgn0004435	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	197/404 - (48%)
Similarity:	264/404 - (65%)	Gaps:	55/404 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    13 CLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEERKG 77
            ||:|:.|...|::|||.:.|...|:..|.||||||||.|||||||||||||||||:|||:|:::|
  Fly     4 CLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRG 68

Human    78 FRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQDPYKVTTFEKRYAAAMQWLWRDA 142
            :..||:||||::|::||:||:.|:|.:.:.|....|.||||.|...|||||..|..|::.||.||
  Fly    69 YIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNAIKTLWDDA 133

Human   143 GIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQDVLRSRMPTTGINEYCFSVQKTN---- 203
            ||:.||:||||:.|.|||.|||..|:|:.:..|:||.||:||.|:|||||.||.|.:::..
  Fly   134 GIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRFSYL 198

Human   204 ---------------------------------------LRIVDVGGQKSERKKWIHCFENVIAL 229
                                                   .|:||||||:|||:|||||||||.::
  Fly   199 SDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENVTSI 263

Human   230 IYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATY 294
            |:|.:||||||.|.|::.||||:||.|||.||:..|||:::||||||||.|:|||||..|||..|
  Fly   264 IFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDY 328

Human   295 FPSFQGPKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDV 359
            ||.:.||::||..|:.|||.|:..:      .|:..|      .::||:||||||:||:.||..|
  Fly   329 FPEYDGPQRDAITAREFILRMFVDL------NPDSEK------IIYSHFTCATDTENIKLVFCAV 381

Human   360 RDSVLARYLDEINL 373
            :|:::...|.|.||
  Fly   382 KDTIMQNALKEFNL 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNA15	NP_002059.3	G_alpha	22..372	CDD:214595	191/392 (49%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	44..57		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	181..189		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	204..213		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	273..280		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	344..349		4/4 (100%)
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	181/367 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820