DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33230 and SETD3

DIOPT Version :9

Sequence 1:	NP_995955.1	Gene:	CG33230 / 2768998	FlyBaseID:	FBgn0053230	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_115609.2	Gene:	SETD3 / 84193	HGNCID:	20493	Length:	594	Species:	Homo sapiens

Alignment Length:	479	Identity:	96/479 - (20%)
Similarity:	175/479 - (36%)	Gaps:	127/479 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GSLHDLYVHLHSVGWQNHTHLSAQYYE-----QTGRGLCSKQKTFSPEDELIRLPIGCLISIATL 79
            |...|.:..|  :.|.:....|.:.:|     :.|.|| ...:....|:..:.:|...|:::.:.
Human    73 GKREDYFPDL--MKWASENGASVEGFEMVNFKEEGFGL-RATRDIKAEELFLWVPRKLLMTVESA 134

  Fly    80 ESD--GPFKSLFDEELFDKDSRISFQAL----IACYILYHKHLQECTLGTHSSTYAAYLDTLPRC 138
            ::.  ||        |:.:| || .||:    :|.::|       |...:.:|.:..|:.|||..
Human   135 KNSVLGP--------LYSQD-RI-LQAMGNIALAFHLL-------CERASPNSFWQPYIQTLPSE 182

  Fly   139 YSTPYFCSIPELQCLPESLLERTVAQN-----RQIRGYFEIIKNIVHKCDCCGKSYGQEIWTLAD 198
            |.||.:....|::.|..:.....|...     ||...::::|:...|    ..|...::.:|..|
Human   183 YDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPH----ANKLPLKDSFTYED 243

  Fly   199 FKWAYFSVNTRSVHLSSRFLKKQSNYFQPLISGD-TNLALAPFLDLFNHSDQVEITAGIEGPDYV 262
            ::||..||.||...:             |...|. ..|||.|..|:.||::.: ||.|....|.
Human   244 YRWAVSSVMTRQNQI-------------PTEDGSRVTLALIPLWDMCNHTNGL-ITTGYNLEDD- 293

  Fly   263 LTLKSLPFSETKPYDQLFISYGALPNFKLLTEYGFWLRENKHDYFEVSL--LDIEHMIKQNKEL- 324
             ..:.:...:.:..:|::|.||...|.:.:...||:...|.||..::.|  ...:.:.....|:
Human   294 -RCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVL 357

  Fly   325 --------STQTFH-------RNIFKFIR----------EHNLND-------------------- 344
                    |....|       ..:..|:|          ||.|.|
Human   358 ARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDN 422

  Fly   345 --QMFVHIDDGCSHNLRVVLHLIFKQQAYFPNILNQIAFGDAEQFQDVQPELSYLVEYKIKEYEI 407
              :::..::|..|..|:.....|.:.::...|             .|:.......::.::.|.||
Human   423 EVKLWTFLEDRASLLLKTYKTTIEEDKSVLKN-------------HDLSVRAKMAIKLRLGEKEI 474

  Fly   408 FGGELDKLPKLTESGAVARSYLQE 431
                   |.|..:|.||.|.|.::
Human   475 -------LEKAVKSAAVNREYYRQ 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33230	NP_995955.1	T6SS_VipB	<229..>314	CDD:301628	23/87 (26%)
SETD3	NP_115609.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SET_SETD3	80..329	CDD:380953	65/288 (23%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:30626964, ECO:0000269\|PubMed:30785395, ECO:0000269\|PubMed:31388018, ECO:0000269\|PubMed:31911441, ECO:0000269\|PubMed:31993215, ECO:0000269\|PubMed:32503840, ECO:0000269\|Ref.12, ECO:0007744\|PDB:3SMT, ECO:0007744\|PDB:6ICT, ECO:0007744\|PDB:6ICV, ECO:0007744\|PDB:6JAT, ECO:0007744\|PDB:6MBJ, ECO:0007744\|PDB:6MBK, ECO:0007744\|PDB:6MBL, ECO:0007744\|PDB:6OX0, ECO:0007744\|PDB:6OX1, ECO:0007744\|PDB:6OX2, ECO:0007744\|PDB:6OX3, ECO:0007744\|PDB:6OX4, ECO:0007744\|PDB:6OX5, ECO:0007744\|PDB:6V62, ECO:0007744\|PDB:6V63, ECO:0007744\|PDB:6WK1, ECO:0007744\|PDB:6WK2	104..106		0/1 (0%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:30626964, ECO:0000269\|PubMed:30785395, ECO:0000269\|PubMed:31388018, ECO:0000269\|PubMed:31911441, ECO:0000269\|PubMed:31993215, ECO:0000269\|PubMed:32503840, ECO:0000269\|Ref.12, ECO:0007744\|PDB:3SMT, ECO:0007744\|PDB:6ICT, ECO:0007744\|PDB:6ICV, ECO:0007744\|PDB:6JAT, ECO:0007744\|PDB:6MBJ, ECO:0007744\|PDB:6MBK, ECO:0007744\|PDB:6MBL, ECO:0007744\|PDB:6OX0, ECO:0007744\|PDB:6OX1, ECO:0007744\|PDB:6OX2, ECO:0007744\|PDB:6OX3, ECO:0007744\|PDB:6OX4, ECO:0007744\|PDB:6OX5, ECO:0007744\|PDB:6V62, ECO:0007744\|PDB:6V63, ECO:0007744\|PDB:6WK1, ECO:0007744\|PDB:6WK2	275..279		1/3 (33%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:30626964, ECO:0000269\|PubMed:30785395, ECO:0000269\|PubMed:31388018, ECO:0000269\|PubMed:31911441, ECO:0000269\|PubMed:31993215, ECO:0000269\|PubMed:32503840, ECO:0000269\|Ref.12, ECO:0007744\|PDB:3SMT, ECO:0007744\|PDB:6ICT, ECO:0007744\|PDB:6ICV, ECO:0007744\|PDB:6JAT, ECO:0007744\|PDB:6MBJ, ECO:0007744\|PDB:6MBK, ECO:0007744\|PDB:6MBL, ECO:0007744\|PDB:6OX0, ECO:0007744\|PDB:6OX1, ECO:0007744\|PDB:6OX2, ECO:0007744\|PDB:6OX3, ECO:0007744\|PDB:6OX4, ECO:0007744\|PDB:6OX5, ECO:0007744\|PDB:6V62, ECO:0007744\|PDB:6V63, ECO:0007744\|PDB:6WK1, ECO:0007744\|PDB:6WK2	325..327		0/1 (0%)
		Rubis-subs-bind	350..475	CDD:401276	18/144 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840