DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33230 and SETD4

DIOPT Version :9

Sequence 1:	NP_995955.1	Gene:	CG33230 / 2768998	FlyBaseID:	FBgn0053230	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_059134.1	Gene:	SETD4 / 54093	HGNCID:	1258	Length:	440	Species:	Homo sapiens

Alignment Length:	433	Identity:	106/433 - (24%)
Similarity:	179/433 - (41%)	Gaps:	78/433 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GRTQRRRHQRAKKSDENSG---SLHDLYVHLHSVGWQ-----NHTHLSAQYYEQTGRGLCSKQKT 58
            |||.|.|.::...|.|:.|   |....::.|..  |.     ..::|:...:..|||||.| |.:
Human     6 GRTSRIRRRKLCGSSESRGVNESHKSEFIELRK--WLKARKFQDSNLAPACFPGTGRGLMS-QTS 67

  Fly    59 FSPEDELIRLPIGCLISIATLESDGPFKSLFDEELFDKDSRISFQALIACYILYHKH-----LQE 118
            ......:|.||..||::..|:                      .::.:..||...|.     |..
Human    68 LQEGQMIISLPESCLLTTDTV----------------------IRSYLGAYITKWKPPPSPLLAL 110

  Fly   119 CTL------GTHSSTYAAYLDTLPRCYSTPYFCSIPE-LQCLPESLLERTVAQNRQIRGYFEIIK 176
            ||.      ..|.|.:..||:.||:.|:.| .|..|| :..||:||..:...|...::.:|...:
Human   111 CTFLVSEKHAGHRSLWKPYLEILPKAYTCP-VCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSR 174

  Fly   177 NIVHKCDCCGKSYGQEIWTLADFKWAYFSVNTRSVHLSSRFLKKQSNYFQPLISGDTNLALAPFL 241
            :...............|::.:...||:.:||||:|:|..|  :::....:|    || .||||:|
Human   175 DFFSSLQPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPR--QRECLSAEP----DT-CALAPYL 232

  Fly   242 DLFNHSDQVEITAGIEGPDYVLTLKSLPFSETKPYDQLFISYGALPNFKLLTEYGFWLRENKHDY 306
            ||.|||..|::.|......:...:::.  |..:.::::||.||...|.:|..||||....|.|..
Human   233 DLLNHSPHVQVKAAFNEETHSYEIRTT--SRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHAC 295

  Fly   307 FEVSL-LDIEHMIKQNKELSTQTFHRNIFKFIREHNLNDQMFVHID------DGCSHNLRVVLHL 364
            ..||. :.::::...:|::..:      ...:::|.       :|:      ||.|..|...|.|
Human   296 VYVSREILVKYLPSTDKQMDKK------ISILKDHG-------YIENLTFGWDGPSWRLLTALKL 347

  Fly   365 IFKQQAYFPNILNQIAFGDAEQFQDVQPELSYLVEYKIKEYEI 407
            :..:...| ....::..|  |...|...:.|..:..||..|.|
Human   348 LCLEAEKF-TCWKKVLLG--EVISDTNEKTSLDIAQKICYYFI 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33230	NP_995955.1	T6SS_VipB	<229..>314	CDD:301628	29/85 (34%)
SETD4	NP_059134.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		7/17 (41%)
		SET	<210..273	CDD:279228	20/71 (28%)
		Rubis-subs-bind	317..425	CDD:286371	17/87 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158345
Domainoid	1	1.000	72	1.000	Domainoid score	I9420
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41173
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49443
OrthoDB	1	1.010	-	-		D1209399at2759
OrthoFinder	1	1.000	-	-		FOG0005857
OrthoInspector	1	1.000	-	-		oto90978
orthoMCL	1	0.900	-	-		OOG6_105100
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	1	1.000	-	-		X4855
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700