DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33230 and Setd4

DIOPT Version :9

Sequence 1:	NP_995955.1	Gene:	CG33230 / 2768998	FlyBaseID:	FBgn0053230	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001107219.1	Gene:	Setd4 / 245975	RGDID:	619899	Length:	439	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	119/454 - (26%)
Similarity:	194/454 - (42%)	Gaps:	63/454 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GRTQR-RRHQRAKKSDENSGSLHDLYVHLHSVGWQNHTHLSAQYYEQ-----------TGRGLCS 54
            |||:| ||.:|:..|...:.|....::.|..  |     |..:.:|.           |||||.|
  Rat     6 GRTERVRRRRRSSGSRGVNESCRSEFIELRK--W-----LKERKFEDTGLLVPACFPGTGRGLMS 63

  Fly    55 KQKTFSPEDELIRLPIGCLISIATL--ESDGPFKSLFDEELFDKDSRISFQALIACYILYHKHLQ 117
            | .:......:|.||..||::..|:  .|.||:...:...       :|....:..:::..:|
  Rat    64 K-ASLQEGQVIISLPESCLLTTDTVIRSSVGPYIKKWKPP-------VSPLLALCTFLVSERH-- 118

  Fly   118 ECTLGTHSSTYAAYLDTLPRCYSTPYFCSIPE-LQCLPESLLERTVAQNRQIRGYFEIIKNIVHK 181
               .|:| |.:.:|||.||:.|:.| .|..|| :..||..|..:...|..:::..|...::....
  Rat   119 ---AGSH-SLWKSYLDILPKSYTCP-VCLEPEVVDLLPGPLRAKAEEQRARVQDLFASSRDFFST 178

  Fly   182 CDCCGKSYGQEIWTLADFKWAYFSVNTRSVHLSSRFLKKQSNYFQPLISGDTNLALAPFLDLFNH 246
            ...........|::...|.||:.:||||:|:|.||   :|    :.|.|.....||||||||.||
  Rat   179 LQPLFAESVDSIFSYHAFLWAWCTVNTRAVYLKSR---RQ----ECLSSEPDTCALAPFLDLLNH 236

  Fly   247 SDQVEITAGIEGPDYVLTLKSLPFSETKPYDQLFISYGALPNFKLLTEYGFWLRENKHDYFEVS- 310
            |..|::.|..........:::.  |..:.:.:.||.||...|.:||.||||....|.|....||
  Rat   237 SPHVQVKAAFNEKTRCYEIRTA--SRCRKHQEAFICYGPHDNQRLLLEYGFVAFGNPHACVPVSG 299

  Fly   311 -LLDIEHMIKQNKELSTQTFHRNIFKFIREHNLNDQMFVHIDDGCSHNLRVVLHLIFKQQAYFPN 374
             :| ::::...:|::     |:.: ..:.:|.....:.... ||.|..|...|.|:..:...|.:
  Rat   300 EML-LKYLPPADKQV-----HKKL-SILEDHGFTGNLTFGW-DGPSWRLLTALKLLCLEAERFTS 356

  Fly   375 ILNQIAFGDAEQFQDVQPELSYLVEYKIKEYEI--FGGELDKLPKLTE--SGAVARSYLQECIR 434
             ..::..||.  ..|...:.|..|..||....|  ...||.|:..:.|  ...:::..|.|.:|
  Rat   357 -WKKVLIGDV--ISDRNEKASLGVAQKICSDFIAEIHSELRKVSDMKERKGSLISQLCLVEALR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33230	NP_995955.1	T6SS_VipB	<229..>314	CDD:301628	31/86 (36%)
Setd4	NP_001107219.1	Rubis-subs-bind	316..424	CDD:286371	23/107 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352330
Domainoid	1	1.000	74	1.000	Domainoid score	I8972
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41173
Inparanoid	1	1.050	93	1.000	Inparanoid score	I4987
OMA	1	1.010	-	-		QHG49443
OrthoDB	1	1.010	-	-		D1209399at2759
OrthoFinder	1	1.000	-	-		FOG0005857
OrthoInspector	1	1.000	-	-		oto98073
orthoMCL	1	0.900	-	-		OOG6_105100
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4855
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.670