DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12038 and Dipk1b

DIOPT Version :9

Sequence 1:	NP_995949.1	Gene:	CG12038 / 2768997	FlyBaseID:	FBgn0035179	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_062807.2	Gene:	Dipk1b / 56279	MGIID:	1927576	Length:	431	Species:	Mus musculus

Alignment Length:	442	Identity:	98/442 - (22%)
Similarity:	158/442 - (35%)	Gaps:	136/442 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLIAVLLAVGIF-----------SYAFLNLKFCFKLMSHRSLNLMCQKFEKHEYSGSLCEELCGS 70
            |...:|:.:|||           ||:    :.|   ..|....::|.::.|...|||:|::||..
Mouse    29 VKYVLLVWLGIFVGSWMVYVHYSSYS----ELC---RGHVCQVVICDQYRKGIISGSVCQDLCEL 86

  Fly    71 QSSFDNFQCPLNDMKTILFTAEKNGDLYAVKLARHNDDEL-------------SWTN-------- 114
            |..         :.:|.|.:| ....:|:   ....|.|:             :|.:
Mouse    87 QKV---------EWRTCLSSA-PGQQVYS---GLWQDKEVTIKCGIEEALNSKAWPDAAPRRELV 138

  Fly   115 -----NKGESIYPKLEEFHEIVKLHIILAY-NVTLDD-NMIRALVNQEI--ADDNSQQMVSF--- 167
                 .:|.||    :||.|:.     |:: ...|.| ..:.|||:|.:  ||.|....||.
Mouse   139 LFDKPTRGTSI----KEFREMT-----LSFLKANLGDLPSLPALVDQILLMADFNKDSRVSLAEA 194

  Fly   168 ---WRLFKDNNYMMGKLFDEESIFPAVLGSCGPYYATEGL------------EIVQSNPSIM--- 214
               |.|.:.|.:::.....|:.....:||.||..|.|||:            .:....||::
Mouse   195 KSVWALLQRNEFLLLLSLQEKEHASRLLGYCGDLYLTEGIPHGSWHGAVLLPALRPLLPSVLHRA 259

  Fly   215 --QYLASNRVQRLKHALNIMEYIFRLDEMKPEPLKMCKMQVNRFGTASERRLKYQSAEHVYVESQ 277
              |:.......|.|.|:.::|::..|.........||:..:...|..:....|....:.|..|:.
Mouse   260 LQQWFGPAWPWRAKIAIGLLEFVEELFHGSYGTFYMCETTLANVGYTATYDFKMADLQQVAPEAT 324

  Fly   278 LDKRLSRGVKCHAHQDCHF-HSCRGLCDEEKQSCTHIQQNNNFQIFCEHILLGGGTFQPGLLSGV 341
            : :|..:|..|....||.: ..||..||...:.|.                  |...||
Mouse   325 V-RRFLQGRHCEQSSDCIYGRDCRAPCDRLMRQCK------------------GDLIQP------ 364

  Fly   342 RLSKALQKLVKMCVQPPKEHQVPGRQWAPNTQLALRLYNEL-KQLHQAATAS 392
                   .|.|:| :..:::.:||   ||     ..||.|| |||....|.|
Mouse   365 -------NLAKVC-ELLRDYLLPG---AP-----AGLYEELGKQLRTCTTLS 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12038	NP_995949.1	PIP49_N	10..153	CDD:291537	36/174 (21%)
CG12038	NP_995949.1	PIP49_C	167..357	CDD:289064	42/213 (20%)
Dipk1b	NP_062807.2	May mediate ER retention	5..6
		PIP49_N	23..179	CDD:291537	38/178 (21%)
		PIP49_C	198..399	CDD:289064	53/241 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850530
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49292
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001987
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21093
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950