DRSC/TRiP Functional Genomics Resources

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Protein Alignment aln and DIPK1B

DIOPT Version :10

Sequence 1:NP_995949.1 Gene:aln / 2768997 FlyBaseID:FBgn0035179 Length:407 Species:Drosophila melanogaster
Sequence 2:NP_689634.2 Gene:DIPK1B / 138311 HGNCID:28290 Length:431 Species:Homo sapiens


Alignment Length:358 Identity:79/358 - (22%)
Similarity:137/358 - (38%) Gaps:78/358 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 RTVLIAVLLAVGIFSYAFL----NLKFCFKLMSHRSLNLMCQKFEKHEYSGSLCEELCGSQSSFD 75
            |.:.:|.|   |:|:.::|    ...:..:...|....::|.::.|...|||:|::||       
Human    30 RCIFLAWL---GVFAGSWLVYVHYSSYSERCRGHVCQVVICDQYRKGIISGSVCQDLC------- 84

  Fly    76 NFQCPLNDMKTILFTAEKNGDLYAVKLARHNDDEL-----SWTNNKGES---------IYPK--- 123
              :..:.:.:|.|..|.  |......|.|..|..:     ...::|..|         ::.|   
Human    85 --ELHMVEWRTCLSVAP--GQQVYSGLWRDKDVTIKCGIEETLDSKARSDAAPRRELVLFDKPTR 145

  Fly   124 ---LEEFHEIVKLHIILAY-NVTLDD-NMIRALVNQEI--ADDNSQQMVSF------WRLFKDNN 175
               ::||.|:.     |:: ...|.| ..:.|||.|.:  ||.|....||.      |.|.:.|.
Human   146 GTSIKEFREMT-----LSFLKANLGDLPSLPALVGQVLLMADFNKDNRVSLAEAKSVWALLQRNE 205

  Fly   176 YMMGKLFDEESIFPAVLGSCGPYYATEGL-------------------EIVQSNPSIMQYLASNR 221
            :::.....|:.....:||.||..|.|||:                   ..:|.  ::.|:|....
Human   206 FLLLLSLQEKEHASRLLGYCGDLYLTEGVPHGAWHAAALPPLLRPLLPPALQG--ALQQWLGPAW 268

  Fly   222 VQRLKHALNIMEYIFRLDEMKPEPLKMCKMQVNRFGTASERRLKYQSAEHVYVESQLDKRLSRGV 286
            ..|.|.|:.::|::..|.........||:..:...|..:....|....:.|..|:.: :|..:|.
Human   269 PWRAKIAIGLLEFVEELFHGSYGTFYMCETTLANVGYTATYDFKMADLQQVAPEATV-RRFLQGR 332

  Fly   287 KCHAHQDCHF-HSCRGLCDEEKQSCTH--IQQN 316
            :|....||.: ..||..||...:.|..  ||.|
Human   333 RCEHSTDCTYGRDCRAPCDRLMRQCKGDLIQPN 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alnNP_995949.1 PIP49_N 10..153 CDD:464353 33/163 (20%)
PIP49_C 167..357 CDD:463512 39/178 (22%)
DIPK1BNP_689634.2 May mediate ER retention. /evidence=ECO:0000250 5..6
PIP49_N 23..179 CDD:464353 35/167 (21%)
PIP49_C 197..399 CDD:463512 39/172 (23%)
Blue background indicates that the domain is not in the aligned region.

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