DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12038 and DIPK1C

DIOPT Version :9

Sequence 1:	NP_995949.1	Gene:	CG12038 / 2768997	FlyBaseID:	FBgn0035179	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001037834.2	Gene:	DIPK1C / 125704	HGNCID:	31729	Length:	419	Species:	Homo sapiens

Alignment Length:	419	Identity:	98/419 - (23%)
Similarity:	162/419 - (38%)	Gaps:	92/419 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLIAVLLA---VGIFSYAFLNLKFCFKLMSHRSLNLMCQKFEKHEYSGSLCEELCGSQSSFDNFQ 78
            ||.|.||.   .|:.|      :.|....|.|.|..:||.::....:|.|||:||.:....  ||
Human    36 VLAAALLLRAHPGVLS------ERCTDEKSRRILAALCQDYQGGTLAGDLCEDLCVAGELL--FQ 92

  Fly    79 CPL--NDMKTILFTAEKNGDLYAVKLARHNDDELSWTNNKGESIYPKLEEFHE----------IV 131
            ..|  |..|.:| .|:..|....:|           :..:..|.:|.|....|          ..
Human    93 RCLHYNRGKKVL-QADWRGRPVVLK-----------SKEEAFSSFPPLSLLEEEAGEGGQDMPEA 145

  Fly   132 KLHIILAYNVTLDDNMIRALVNQEIADDN-------------SQQMVSFWRLFKDNNYMMGKLFD 183
            :|.:::|       ..:::.:..|:::.:             ..|:.|.|.|.:...|:...|..
Human   146 ELLLMVA-------GEVKSALGLELSNSSLGPWWPGRRGPRWRGQLASLWALLQQEEYVYFSLLQ 203

  Fly   184 EES--IFPAVLGSCGPYYATE-------------GLEIVQSNPSIMQYLASNRVQRLKHALNIME 233
            :.|  :.| ||||||.:||.|             .|:.....|...|..|.:.:     ||:.::
Human   204 DLSPHVLP-VLGSCGHFYAVEFLAAGSPHHRALFPLDRAPGAPGGGQAKAISDI-----ALSFLD 262

  Fly   234 YIFRLDEMKPEPLKMCKMQVNRFGTASERRLKYQSAEHVYVESQLDKRLSRGVKCHAHQDCHFHS 298
            .:...|......|.:|.::...|...|:..:.....:..:.|.::.:.|.:  .|...:||:|..
Human   263 MVNHFDSDFSHRLHLCDIKPENFAIRSDFTVVAIDVDMAFFEPKMREILEQ--NCTGDEDCNFFD 325

  Fly   299 CRGLCDEEKQSCTHIQQNNNFQIFCEHILLGGGTFQPGLLSGV---RLSKALQKLVKMCVQPPKE 360
            |...||.....|...:.|||.|:.|:.|.  ...|...|.|..   :|...||:.|:.|..|
Human   326 CFSRCDLRVNKCGAQRVNNNLQVICDKIF--RHWFSAPLKSSAVSFQLQLQLQEAVQECADP--- 385

  Fly   361 HQVPGRQWAPNT-QLALRLYNELKQLHQA 388
             .||    :.|| :.|..::.:|:||.||
Human   386 -GVP----SGNTRRAASSVFWKLRQLLQA 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12038	NP_995949.1	PIP49_N	10..153	CDD:291537	34/150 (23%)
CG12038	NP_995949.1	PIP49_C	167..357	CDD:289064	50/207 (24%)
DIPK1C	NP_001037834.2	May mediate ER retention. /evidence=ECO:0000250	16..17
		PIP49_N	24..168	CDD:291537	35/158 (22%)
		PIP49_C	187..385	CDD:289064	50/207 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160156
Domainoid	1	1.000	56	1.000	Domainoid score	I11101
eggNOG	1	0.900	-	-		E1_28K8P
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I5388
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49292
OrthoDB	1	1.010	-	-		D1035909at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto91050
orthoMCL	1	0.900	-	-		OOG6_109430
Panther	1	1.100	-	-	LDO	PTHR21093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3375
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.800