DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and Btbd11

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_082985.2	Gene:	Btbd11 / 74007	MGIID:	1921257	Length:	1109	Species:	Mus musculus

Alignment Length:	1203	Identity:	408/1203 - (33%)
Similarity:	587/1203 - (48%)	Gaps:	266/1203 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 GKAPWSGTGLEDIKLAMLTLRS----QTSSSTYSSLSAGSESSEPARRLG-------------RY 548
            ||.|...| |||     |||.|    ...|...|:||.....|.||...|             |:
Mouse     5 GKKPVVRT-LED-----LTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMHSRH 63

  Fly   549 SSLETVVTSTSADE--FVWVDSH-NRLV-ELQHPPWSQQCILKVLRNGRCQQQAE----HLAVEA 605
            :|.:||.|:...|.  ......| :||: :|...||:.|.:..:|...|..:...    .|..:|
Mouse    64 NSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELELLLLRSRDPRAGPAVPGSLPKDA 128

  Fly   606 VSRLGYLLQRALVRIAREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMF--AV 668
            :::|..|:.|||||||:|.||.|.....|:|.|:..|:.:|||..||..||.|.|.:.:::  :.
Mouse   129 LAKLSMLVSRALVRIAKEAQRLSLRFAKCTKYEIQSAMEIVLSWGLAAHCTAAALAALSLYNMSS 193

  Fly   669 PGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI---------A 724
            .|...|.:.||||.||..||||.||||.|:|:...|||:||:||.|.:|:|..:|         .
Mouse   194 AGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVLASGLP 258

  Fly   725 LQCNG------------------------------------------------------------ 729
            ..|:|
Mouse   259 RSCSGPGPGSSSGSGPGPGSGPGAPAADKERETPGGGAASGGPCSAASSASGGSSCCAPPATAAT 323

  Fly   730 ----TTAAA-----------------------LDQSIASSGDVWGLLQPFAHLNAGRIASGALAL 767
                |||.|                       |:.::.:..::||||||:.||..|:.|||.|:|
Mouse   324 AVPPTTATAAVAANHHHHHHTLHEAPKFTVETLEHTVNNDSEIWGLLQPYQHLICGKNASGVLSL 388

  Fly   768 PRWAN-----------------------SLDQVIASSGDFRGHLATCVGSIRELKEKALRTQQEF 809
            |...|                       :::|.:         |||.||||.||.:...|.....
Mouse   389 PESLNLHRDPQRPSKPGELPMFSQSELRTIEQSL---------LATRVGSIAELSDLVSRAMHHL 444

  Fly   810 Q-LAAALSGS----------------ALAALFYFMRCSQLEHTELLAASGCHAGQAQSAAPGGGT 857
            | |.|...|:                ||..|.|||.|.|:|...                |....
Mouse   445 QPLNAKHHGNGTPMHHKQGALYWEPEALYTLCYFMHCPQMEWEN----------------PNVEP 493

  Fly   858 SSAGHHVQELCYERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKDDVMQAARLLLPGVDCPIRPVA 922
            |.....|     ||.::|||||.||:|||.|||.||.:..:|.|||.||||||||||||..|.:.
Mouse   494 SKVNLQV-----ERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLK 553

  Fly   923 HDEELPTKKTHFNTAPTVSSTGTGTGSSSCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTG 987
            .|:                        ..|:|..:..:.|       |...:..:|  |::|..|
Mouse   554 ADD------------------------CFCASRKLDAVAI-------EAKFKQDLG--FRMLNCG 585

  Fly   988 RAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPA 1052
            |.:|:.||..||.| ...:|.:..|:|.||.|.:|.||..:..|||||.|.||||...... ||:
Mouse   586 RTDLVKQAVSLLGP-DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHK-YPS 648

  Fly  1053 IQPDTQHWTALSFAASRANYVALRILLERGGKVEGGARSSEEKCTLTPLQLAAGTGNLEIVALLL 1117
            :.|:|:|||||:||....:...:::||:.|.||||.....||..:.|||||||..||.|:|:|||
Mouse   649 VHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLL 713

  Fly  1118 AHGANAFLSTQQKDSLCFAGSAQKGCFCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLA 1182
            ..||:..:.|..::.:   .:..:|...:.|.|||||||:..||||..|....: |:|||||:||
Mouse   714 ERGADPLIGTMYRNGI---STTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS-DILSLEEILA 774

  Fly  1183 EG-DVGGVRGSGGPTGAGGPNSASASGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRK 1246
            || |:...          .|....||.|        :|.:::.|:||||||||:.::|:||::|.
Mouse   775 EGTDLAET----------APPPLCASRN--------SKAKLRALREAMYHSAEHGYVDVTIDIRS 821

  Fly  1247 LGVPWTLHCWMHALSAAHDLRLDAVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGT 1310
            :|||||||.|:.:|..|.......:|..||::|..:..::|:.:.|::.|||:|.|.: :|||..
Mouse   822 IGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVI 886

  Fly  1311 TLLLADIFATCFGWETLPPVKEQPPMQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVT 1375
            :..|..||..|:|...:|.:.|   ::..|.||:||.|:||.|:|||||.|||:.||.||::|.|
Mouse   887 SQQLCVIFTHCYGPYPIPKLTE---IKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFT 948

  Fly  1376 ASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQ 1440
            |||||:::||||.:..::  .::|..::|.|||||||:||.||..||.:.:.:::||::||.|||
Mouse   949 ASPRFKALLSSKPTNDNT--CIEIGYVKYPIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQ 1011

  Fly  1441 LEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAK 1505
            ||.|.|:.|..|::.::.||.|.:|.|||......|..:|:.:.|:||:.|:. :::.|:||:.|
Mouse  1012 LEALQRHCEIICAKSINTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIE-NEAFKQLLYDK 1075

  Fly  1506 --KIPNHDVLAGLLQTLQNRLKARKPNSGGGLV 1536
              :....|||..|.:||..|:::...:|..|.|
Mouse  1076 NGEGAGQDVLQDLQRTLAIRIQSIHLSSSKGSV 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	27/61 (44%)
		ANK	1006..1163	CDD:238125	67/156 (43%)
		ANK repeat	1012..1056	CDD:293786	20/43 (47%)
		Ank_2	1016..1122	CDD:289560	51/105 (49%)
		ANK repeat	1058..1091	CDD:293786	14/32 (44%)
		ANK repeat	1093..1121	CDD:293786	16/27 (59%)
		ANK repeat	1141..1173	CDD:293786	14/31 (45%)
		BTB	1350..1446	CDD:279045	51/95 (54%)
		BTB	1356..1449	CDD:197585	48/92 (52%)
		SPOP_C_like	1456..>1492	CDD:269810	12/35 (34%)
Btbd11	NP_082985.2	H2A	200..>244	CDD:305064	25/43 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..302		2/41 (5%)
		Ank_4	<585..629	CDD:290365	17/44 (39%)
		ANK	603..756	CDD:238125	67/156 (43%)
		ANK 1	608..637		14/28 (50%)
		ANK repeat	611..652	CDD:293786	19/41 (46%)
		Ank_2	613..721	CDD:289560	52/108 (48%)
		ANK repeat	654..685	CDD:293786	14/30 (47%)
		ANK 2	654..683		12/28 (43%)
		ANK repeat	687..717	CDD:293786	16/29 (55%)
		ANK 3	692..721		16/28 (57%)
		Ank_2	697..>757	CDD:289560	27/62 (44%)
		ANK 4	735..764		14/28 (50%)
		ANK 5	830..859		7/28 (25%)
		BTB	920..1023	CDD:279045	54/104 (52%)
		BTB	929..1027	CDD:197585	50/99 (51%)
		BACK_like	1027..>1071	CDD:297737	14/44 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4822
eggNOG	1	0.900	-	-		E1_28KA7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	597	1.000	Inparanoid score	I949
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49645
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm43654
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	O	PTHR46071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5139
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870