DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and btbd11a

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001314771.1	Gene:	btbd11a / 562893	ZFINID:	ZDB-GENE-050419-142	Length:	1021	Species:	Danio rerio

Alignment Length:	1118	Identity:	403/1118 - (36%)
Similarity:	589/1118 - (52%)	Gaps:	181/1118 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 GKAPWSGTGLEDIKL------AMLTLRSQT----SSSTYSSLSAG------SESSEPARRLGRYS 549
            ||...:...|||:.|      |..:.||.:    .|.|:.|.:.|      :||..     .|::
Zfish     3 GKGKTAARTLEDLTLDSGYGGAADSFRSSSVSLCCSDTHLSYAHGGNCWHLTESMH-----SRHN 62

  Fly   550 SLETVVTSTSADEFVWVDSHN--RLVELQHP-PWSQQCILKVLRNGRCQQQAEHLAV-----EAV 606
            ||:||.|..:.|..:...|..  :|.||:.. |||...:...||      :.|.|.|     |.:
Zfish    63 SLDTVNTVLAEDTEILECSGQCAKLPELEEDVPWSLGEVEGALR------KDEELCVGNASREIL 121

  Fly   607 SRLGYLLQRALVRIAREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMFAVPGE 671
            ::|..|:.|||||||||.||.|.....|:|.|:..|:::|||.:::.:|..|.|.:.:::.:...
Zfish   122 AKLSALVSRALVRIAREAQRMSLRYARCTKHEIQSAIKMVLSWTISVNCITAALSALSLYNMSTG 186

  Fly   672 SALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQC--------- 727
            ....:.||.|.||..|||:|:|||.|:|:...|||:||:||.|.:|:|..|:..:.
Zfish   187 DKFSRGKSTRCGLIFSVGKFFRWMVDSRVALRIHEHAAIYLSACMESLFREVFTRVQRSALVEKE 251

  Fly   728 NGT---TAAALDQSIASSGDVWGLLQPFAHLNAGRIASGALALPRWANSLD-----QVIASSGDF 784
            ||.   :..:|:|:|.:..::||||||:.||..|:.|||.|:||   :||:     |....:|:
Zfish   252 NGVPKFSVESLEQAINNDSELWGLLQPYQHLICGKNASGVLSLP---DSLNLHRDQQRAGKTGE- 312

  Fly   785 RGH--------------LATCVGSIRELKE---KALRTQQEFQLAAALSGS-------------- 818
             ||              |||.||||.||.:   :|:...|...:....:|:
Zfish   313 -GHAYSQAELRTIEQSLLATRVGSIAELSDLVSRAMHHLQPLHIKNPSNGTPVHQNRTGSVHWEP 376

  Fly   819 -ALAALFYFMRCSQLEHTELLAASGCHAGQAQSAAPGGGTSSAGHHVQELCYERAYVVLPPLAEW 882
             ||..|.|||.|.|:|...                |....|....|.     ||.::|||||.||
Zfish   377 EALYTLCYFMHCPQMEWEN----------------PNVEPSKITLHT-----ERPFLVLPPLMEW 420

  Fly   883 LRVAAAHAEHRNAMMIDKDDVMQAARLLLPGVDCPIRPV-AHDEELPTKKTHFNTAPTVSSTGTG 946
            :|||.||.|||.:..:|.|||.||||||||||||..|.: |.|....|:|
Zfish   421 IRVAVAHTEHRRSFSVDSDDVRQAARLLLPGVDCEPRQLKADDCFCATRK--------------- 470

  Fly   947 TGSSSCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSA 1011
            ..::|..:..:..:|                   |::|..||.:|:.||..||.| ...::.:..
Zfish   471 LDAASTEAKFLQDLG-------------------FRMLNCGRTDLVKQAVNLLGP-DGINSMSEQ 515

  Fly  1012 GLTALMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPAIQPDTQHWTALSFAASRANYVALR 1076
            |:|.||.:.:|.||..:..|||||.|.|.|| |:....:|::.|||:..|.|:||....:...::
Zfish   516 GMTPLMYSCVRGDEAMVQMLLDAGADINSEV-PSSLHKHPSVYPDTRQGTPLTFAVLHGHVPVVQ 579

  Fly  1077 ILLERGGKVEGGARSSEEKCTLTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSLCFAGSAQK 1141
            :||:....|||..:.|.|..|.||||||:..||.|:|:|||..||:..:.|..::.:   .|...
Zfish   580 LLLDARANVEGAIQESTENYTETPLQLASAAGNFELVSLLLERGADPLIGTTYRNGI---SSGPL 641

  Fly  1142 GCFCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLAEGDVGGVRGSGGPTGAGGPNSASA 1206
            |...:.|:|||||||:..||||:. |.....||||||||||||.....|               .
Zfish   642 GEMNSYSLAAAHGHRNVFRKLLSQ-VEKDKGDVLSLEEMLAEGSEAVER---------------R 690

  Fly  1207 SGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWMHALSAAHDLRLDAV 1271
            :..||..| ...|.:::.|:||||||||:.|:||||::|.||||||||.|:.:|......:...:
Zfish   691 APQNEGTL-RTGKAKLRALREAMYHSAEHGHVDITIDIRSLGVPWTLHTWLESLRTCFVQQRRPL 754

  Fly  1272 IDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGTTLLLADIFATCFGWETLPPVKEQPP 1335
            |..||:||..:..|:|:.:.::..|||:|.|.| :|||..:..|:.||..|:|...:|.:.|
Zfish   755 IQGLLKDFSCIKEDEYTEELITHGLPLMFQILRASKNEVISQQLSVIFTQCYGPFPIPKLTE--- 816

  Fly  1336 MQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQIN 1400
            ::..|.||:||.|:||.|:|||||.||||.||.||::|.||||||:|:||::  ..:....::|:
Zfish   817 IKKKQTSRLDPHFLNNKEMSDVTFLVEGKPFYAHKVLLFTASPRFKSLLSNR--PAAENTCIEIS 879

  Fly  1401 DIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVAMY 1465
            .::|:|||||||:|||||..||.:.:.:::||::||.||||:.|.|:.|..||:.:..|:.|.:|
Zfish   880 HVKYNIFQLVMQYLYCGGTESLHIRNTEIMELLSAAKFFQLDALQRHCEIICSKNITNDSCVDIY 944

  Fly  1466 IHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAKKI------PNHDVLAGLLQTLQNRL 1524
            .||:...|..|..|.:.|.|:|||.|:.. ::.|:||:....      |::|||..|.|||..|:
Zfish   945 KHARFLGALELAGFIEGFFLKNMVLLIEL-ENFKQLLYEVPADSPGPGPSYDVLHDLEQTLALRI 1008

  Fly  1525 KA-RKPNSGGGLV 1536
            :: ....|.|.:|
Zfish  1009 RSIHLSTSKGSIV 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	25/61 (41%)
		ANK	1006..1163	CDD:238125	61/156 (39%)
		ANK repeat	1012..1056	CDD:293786	18/43 (42%)
		Ank_2	1016..1122	CDD:289560	45/105 (43%)
		ANK repeat	1058..1091	CDD:293786	9/32 (28%)
		ANK repeat	1093..1121	CDD:293786	15/27 (56%)
		ANK repeat	1141..1173	CDD:293786	14/31 (45%)
		BTB	1350..1446	CDD:279045	51/95 (54%)
		BTB	1356..1449	CDD:197585	48/92 (52%)
		SPOP_C_like	1456..>1492	CDD:269810	13/35 (37%)
btbd11a	NP_001314771.1	H2A	190..276	CDD:305064	32/85 (38%)
		ANK	510..663	CDD:238125	61/156 (39%)
		ANK 1. /evidence=ECO:0000255	515..544		13/28 (46%)
		ANK repeat	518..559	CDD:293786	17/41 (41%)
		Ank_2	520..628	CDD:289560	46/108 (43%)
		ANK repeat	561..594	CDD:293786	9/32 (28%)
		ANK 2. /evidence=ECO:0000255	561..590		7/28 (25%)
		ANK repeat	596..624	CDD:293786	15/27 (56%)
		ANK 3. /evidence=ECO:0000255	599..628		16/28 (57%)
		ANK 4. /evidence=ECO:0000255	642..671		14/29 (48%)
		BTB	828..931	CDD:279045	54/104 (52%)
		BTB	837..935	CDD:197585	51/99 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4075
eggNOG	1	0.900	-	-		E1_28KA7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I959
OMA	1	1.010	-	-		QHG49645
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm24353
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	O	PTHR46071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840