DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and abtb2a

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_687881.4	Gene:	abtb2a / 559451	ZFINID:	ZDB-GENE-100422-13	Length:	1006	Species:	Danio rerio

Alignment Length:	1087	Identity:	385/1087 - (35%)
Similarity:	559/1087 - (51%)	Gaps:	176/1087 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 SGTGLEDIKLAMLTLRSQTSSS--TYSSLSAGSESSEPARRLGRYSSLETVVTSTSADEFVWVDS 568
            ||.|..| ....|:|.|..|:|  ..||...|:..|.......|.:|.:||.|....|....:..
Zfish    19 SGYGAGD-SYRSLSLSSSKSNSQALVSSPQRGNWWSYTGSMNSRNNSWDTVNTVLPEDPEDIISK 82

  Fly   569 HNRLVELQHPPWSQQCILKVLR----NGRCQQQAEHLAVEAVSRLGYLLQRALVRIAREIQRFSA 629
            ..||.||:..||:.:.|..|||    .|.|      .|.|:|..:..|::|||:||:||.||.|.
Zfish    83 CPRLPELEEFPWTDEEIDVVLRKVAGEGLC------FAPESVRSVSVLMRRALLRISREAQRLSV 141

  Fly   630 GVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMFAVPGESALKQSKSARAGLQLSVGRFYRW 694
            ....|::.||..|:::|:|.:||:||..|.:|:.:::::.....|::|||:|..|.||||||:||
Zfish   142 VHCRCTRFEVQSAMKLVMSWALAESCVSAAIRAISLYSMSAGEVLRKSKSSRCALSLSVGRFFRW 206

  Fly   695 MTDARLGKFIHEYAAVYLCAGIENLLEEIALQC-----NGT-----TAAALDQSIASSGDVWGLL 749
            |.|.|:...:|||||:.|.|.||||::||.|:.     |||     ||.||:..:.:..:::||:
Zfish   207 MVDTRISVRVHEYAAICLTACIENLVQEIGLRVLLAAQNGTNSYPVTAEALEAVVCNDAEIFGLV 271

  Fly   750 QPFAHLNAGRIASGALALPR----WANSLDQVIASSGDF----------RGHLATCVGSIRELKE 800
            |.:.||..|:.|:|.|:||.    :|...|..:.|....          :..|||||||:.||.:
Zfish   272 QNYEHLICGKNANGELSLPAHFSLYAEGPDAAVESRETAYAQLELRTLEQALLATCVGSLSELSD 336

  Fly   801 KALRTQQEFQLAAAL-----------------SGSALAALFYFMRCSQLEHTELLAASGCHAGQA 848
            ...|.....|...:.                 |..||..|:|::|..|:|..|
Zfish   337 LVSRAMHHMQRLVSTSPGLSPGRPFCLQPISWSPDALHTLYYYLRSPQMESLE------------ 389

  Fly   849 QSAAPGGGTSSAGHHVQELCY--ERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKDDVMQAARLLL 911
                      :.....|.:..  ||.:.:||||.||:|||..|||||.::::|.|||.|.|||||
Zfish   390 ----------NPNLEPQRIALNKERPFPLLPPLMEWMRVAMVHAEHRRSLLVDSDDVRQTARLLL 444

  Fly   912 PGVDCPIRPVAHD------EELPTKKT--HFNTAPTVSSTGTGTGSSSCSSPVVSGIGIGIGEDT 968
            ||:||..|.:..:      :.|.:|..  .||
Zfish   445 PGLDCEPRQLKPECCFTSFKRLDSKAAMDKFN--------------------------------- 476

  Fly   969 SELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLD 1033
                    :.:.|::|..||.:|:.||.||| .....:|.:..|:|.||.|....||..:|.|:|
Zfish   477 --------LDLGFRMLNCGRTDLIGQAIQLL-GRDGVNTMDDQGMTPLMYACSAGDEALVHMLID 532

  Fly  1034 AGCDPNVEVPPAGSAGYPAIQPDTQHWTALSFAASRANYVALRILLERGGKVEGGA-RSSEEKCT 1097
            ||.:.:|.||.. |..:|::.|:::.|.||:||....:...:::||:.|..|||.| |:|.....
Zfish   533 AGANLDVAVPNC-SPKHPSVHPESRSWVALTFAVLHGHISVVQLLLDVGADVEGRALRNSHHSSA 596

  Fly  1098 LTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSLCFAGSAQKGCFCAISVAAAHGHRSCLRKL 1162
            .||||||:.:||.|:|:|||:.||:..|......|| :.|   ..||   |.|||||||:.||||
Zfish   597 ETPLQLASASGNYEMVSLLLSRGADPMLRVHLTSSL-YEG---MNCF---SHAAAHGHRNVLRKL 654

  Fly  1163 LTHPVSPGTRDVLSLEEMLAEGDVGGVRGSGGPTGAGGPNSASASGNNEDILPLLNKTQIKRLQE 1227
            |:.| .....|||||||:||||     |.........|.|..|...:.      |.|.:|:.|||
Zfish   655 LSEP-QRLQEDVLSLEEILAEG-----REEQEKLEKNGGNMKSVCTSQ------LCKARIRALQE 707

  Fly  1228 AMYHSAENNHLDITIELRKLGVPWTLHCWMHALSAAH-----DLRLDAVIDQLLQDFLQVCPDDY 1287
            |..||||:.:||:::|||.|||.|.||.|:.::.:|.     :|.|     .||:||..:..:.|
Zfish   708 ASLHSAEHGYLDVSMELRALGVSWKLHVWLESIRSAQLHSRTELTL-----SLLKDFTIIGEEKY 767

  Fly  1288 SAQFVSECLPLLFNIFR-NKNEGTTLLLADIFATCFGWETLP---PVKEQPPMQPVQGSRIDPKF 1348
            ..:.::|.||.||:|.: .||:.....||.:|..|......|   .||:.|..|      :|..|
Zfish   768 CEELLAEGLPFLFSIIKTTKNKDIRKQLAAVFCHCVCSTAAPSILAVKDTPTAQ------LDAHF 826

  Fly  1349 VNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSST-PTVQINDIRYHIFQLVMQ 1412
            :||.|:|||.|.|||:.||.|:::|::||.||:.:||...|.|:|. ..::|.||:|:.|:::|.
Zfish   827 LNNSEMSDVIFVVEGRPFYAHRVLLMSASQRFRDLLSLYQSNGTSDHMAIEITDIKYNTFKMMMA 891

  Fly  1413 FLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLL 1477
            .|||||...|||:..|:|:|:..|..|||..|.|:.|..|||.::::|.|::|..|||..|..|:
Zfish   892 HLYCGGAECLDVSASDLLKLLPVAHSFQLPVLKRHCEILCSERINLNNAVSIYRTAKVSEAVELV 956

  Fly  1478 EFCQCFLLQNMVALLTYDDSVKRLLFAKKIPNHDVLAGLLQTLQNRL 1524
            .||:.|:|||||.||..:      .|.:.:.:.:||.||..||.:||
Zfish   957 VFCEGFILQNMVDLLDCE------AFEELLLDPEVLDGLQATLASRL 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	30/57 (53%)
		ANK	1006..1163	CDD:238125	65/157 (41%)
		ANK repeat	1012..1056	CDD:293786	17/43 (40%)
		Ank_2	1016..1122	CDD:289560	44/106 (42%)
		ANK repeat	1058..1091	CDD:293786	12/33 (36%)
		ANK repeat	1093..1121	CDD:293786	13/27 (48%)
		ANK repeat	1141..1173	CDD:293786	16/31 (52%)
		BTB	1350..1446	CDD:279045	45/96 (47%)
		BTB	1356..1449	CDD:197585	42/93 (45%)
		SPOP_C_like	1456..>1492	CDD:269810	16/35 (46%)
abtb2a	XP_687881.4	H2A	187..>235	CDD:305064	27/47 (57%)
		ANK	505..655	CDD:238125	65/157 (41%)
		ANK repeat	513..554	CDD:293786	16/41 (39%)
		Ank_2	515..625	CDD:289560	45/110 (41%)
		ANK repeat	556..590	CDD:293786	12/33 (36%)
		ANK repeat	592..620	CDD:293786	13/27 (48%)
		Ank_4	598..655	CDD:290365	32/63 (51%)
		BTB	825..928	CDD:279045	47/102 (46%)
		BTB	834..935	CDD:197585	46/100 (46%)
		SPOP_C_like	935..986	CDD:269810	19/56 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4075
eggNOG	1	0.900	-	-		E1_28KA7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I959
OMA	1	1.010	-	-		QHG49645
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm24353
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	O	PTHR46071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840