DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and Btbd11

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_038935997.1	Gene:	Btbd11 / 314675	RGDID:	1308647	Length:	1113	Species:	Rattus norvegicus

Alignment Length:	1207	Identity:	413/1207 - (34%)
Similarity:	589/1207 - (48%)	Gaps:	270/1207 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 GKAPWSGTGLEDIKLAMLTLRS----QTSSSTYSSLSAGSESSEPARRLG-------------RY 548
            ||.|...| |||     |||.|    ...|...|:||.....|.||...|             |:
  Rat     5 GKKPVVRT-LED-----LTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMHSRH 63

  Fly   549 SSLETVVTSTSADE--FVWVDSH-NRLV-ELQHPPWSQQ---CILKVLRNGRCQQQAE-HLAVEA 605
            :|.:||.|:...|.  ......| :||: :|...||:.|   .:|...|:.|....|. .|..:|
  Rat    64 NSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELELLLLRSRDPRAGPAAPGSLPKDA 128

  Fly   606 VSRLGYLLQRALVRIAREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMF--AV 668
            :::|..|:.|||||||:|.||.|.....|:|.||..|:.:|||..||..||.|.|.:.:::  :.
  Rat   129 LAKLSMLVSRALVRIAKEAQRLSLRFAKCTKYEVQSAMEIVLSWGLAARCTAAALAALSLYNMSS 193

  Fly   669 PGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQ------- 726
            .|...|.:.||||.||..||||.||||.|:|:...|||:||:||.|.:|:|..:|..:
  Rat   194 AGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYTRVLASGLP 258

  Fly   727 --CNG------------------------------------------------------------ 729
              |:|
  Rat   259 RSCSGPGPGSSSSSGPGPGSGPGAPTADKERETPGGGAASGGPCSAASSASGGSSCCAPPATAAT 323

  Fly   730 ------TTAAA-------------------------LDQSIASSGDVWGLLQPFAHLNAGRIASG 763
                  .||||                         |:.::.:..::||||||:.||..|:.|||
  Rat   324 AVPPATATAAAPTAANHHHHHHHHTLHEAPKFTVETLEHTVNNDSEIWGLLQPYQHLICGKNASG 388

  Fly   764 ALALPRWAN-----------------------SLDQVIASSGDFRGHLATCVGSIRELKEKALRT 805
            .|:||...|                       :::|.:         |||.||||.||.:...|.
  Rat   389 VLSLPESLNLHRDPQRPSKPGELPMFSQSELRTIEQSL---------LATRVGSIAELSDLVSRA 444

  Fly   806 QQEFQ-LAAALSGS----------------ALAALFYFMRCSQLEHTELLAASGCHAGQAQSAAP 853
            ....| |.....|:                ||..|.|||.|.|:|...                |
  Rat   445 MHHLQPLNVKHHGNGTPLHHKQGALYWEPEALYTLCYFMHCPQMEWEN----------------P 493

  Fly   854 GGGTSSAGHHVQELCYERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKDDVMQAARLLLPGVDCPI 918
            ....|.....|     ||.::|||||.||:|||.|||.||.:..:|.|||.||||||||||||..
  Rat   494 NVEPSKVNLQV-----ERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEP 553

  Fly   919 RPVAHDEELPTKKTHFNTAPTVSSTGTGTGSSSCSSPVVSGIGIGIGEDTSELGRRATIGVAFKL 983
            |.:..|:                        ..|:|..:..:.|       |...:..:|  |::
  Rat   554 RQLKADD------------------------CFCASRKLDAVAI-------EAKFKQDLG--FRM 585

  Fly   984 LLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVPPAGSA 1048
            |..||.:|:.||..||.| ...:|.:..|:|.||.|.:|.||..:..|||||.|.|||| .:...
  Rat   586 LNCGRTDLVKQAVSLLGP-DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEV-VSSPH 648

  Fly  1049 GYPAIQPDTQHWTALSFAASRANYVALRILLERGGKVEGGARSSEEKCTLTPLQLAAGTGNLEIV 1113
            .||::.|:|:|||||:||....:...:::||:.|.||||.....||..:.|||||||..||.|:|
  Rat   649 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELV 713

  Fly  1114 ALLLAHGANAFLSTQQKDSLCFAGSAQKGCFCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLE 1178
            :|||..||:..:.|..::.:   .:..:|...:.|.|||||||:..||||..|....: |:||||
  Rat   714 SLLLERGADPLIGTMYRNGI---STTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS-DILSLE 774

  Fly  1179 EMLAEG-DVGGVRGSGGPTGAGGPNSASASGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITI 1242
            |:|||| |:...          .|....||.|        :|.:::.|:||||||||:.::|:||
  Rat   775 EILAEGTDLAET----------APPPLCASRN--------SKAKLRALREAMYHSAEHGYVDVTI 821

  Fly  1243 ELRKLGVPWTLHCWMHALSAAHDLRLDAVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NK 1306
            ::|.:|||||||.|:.:|..|.......:|..||::|..:..::|:.:.|::.|||:|.|.: :|
  Rat   822 DIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASK 886

  Fly  1307 NEGTTLLLADIFATCFGWETLPPVKEQPPMQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKI 1371
            ||..:..|..||..|:|...:|.:.|   ::..|.||:||.|:||.|:|||||.|||:.||.||:
  Rat   887 NEVISQQLCVIFTHCYGPYPIPKLTE---IKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKV 948

  Fly  1372 VLVTASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAA 1436
            :|.||||||:::||||.:..|:  .|:|..::|.|||||||:||.||..||.:.:.:::||::||
  Rat   949 LLFTASPRFKALLSSKPTNDST--CVEIGYVKYPIFQLVMQYLYYGGPESLLIKNNEIMELLSAA 1011

  Fly  1437 SFFQLEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRL 1501
            .|||||.|.|:.|..|::.|:.||.|.:|.|||......|..:|:.:.|:||:.|:. :::.|:|
  Rat  1012 KFFQLEALQRHCEIICAKSVNTDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIE-NEAFKQL 1075

  Fly  1502 LFAK--KIPNHDVLAGLLQTLQNRLKARKPNSGGGLV 1536
            |:.|  :....|||..|.:||..|:::...:|..|.|
  Rat  1076 LYDKNGEGTGQDVLQDLQRTLAIRIQSIHLSSSKGSV 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	27/61 (44%)
		ANK	1006..1163	CDD:238125	67/156 (43%)
		ANK repeat	1012..1056	CDD:293786	20/43 (47%)
		Ank_2	1016..1122	CDD:289560	51/105 (49%)
		ANK repeat	1058..1091	CDD:293786	14/32 (44%)
		ANK repeat	1093..1121	CDD:293786	16/27 (59%)
		ANK repeat	1141..1173	CDD:293786	14/31 (45%)
		BTB	1350..1446	CDD:279045	53/95 (56%)
		BTB	1356..1449	CDD:197585	50/92 (54%)
		SPOP_C_like	1456..>1492	CDD:269810	13/35 (37%)
Btbd11	XP_038935997.1	HTA1	192..>248	CDD:227587	28/55 (51%)
		Ank_2	<589..641	CDD:403870	23/52 (44%)
		ANK repeat	615..656	CDD:293786	19/41 (46%)
		Ank_2	617..723	CDD:403870	52/106 (49%)
		ANK repeat	658..689	CDD:293786	14/30 (47%)
		ANK repeat	691..721	CDD:293786	16/29 (55%)
		BTB_POZ_BTBD11	908..1038	CDD:349660	67/134 (50%)
		BACK_BTBD11	1031..1113	CDD:350602	28/83 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4844
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	583	1.000	Inparanoid score	I973
OMA	1	1.010	-	-		QHG49645
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm45728
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	O	PTHR46071
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980