DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and ABTB2

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_665803.2	Gene:	ABTB2 / 25841	HGNCID:	23842	Length:	1025	Species:	Homo sapiens

Alignment Length:	1099	Identity:	399/1099 - (36%)
Similarity:	597/1099 - (54%)	Gaps:	178/1099 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 LEDIKL-----AMLTLRSQTSSSTYSSLSAGSESSEPARRL----------GRYSSLETVVTSTS 559
            |||:.|     |..:.||.:.||:.|:..|.:.|::..|..          .|::|.:||.|...
Human    12 LEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYSGSMNSRHNSWDTVNTVLP 76

  Fly   560 ADEFVWVDSHN---RLVELQHPPWSQQCILKVLRNGRCQQQAEHLAVEAVSRLGYLLQRALVRIA 621
            .|..| .|..:   ||.||:..||::..:.:|||.|...::....:.|||.||..||:|||:|:|
Human    77 EDPEV-ADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVA 140

  Fly   622 REIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMFAVPGESALKQSKSARAGLQL 686
            ||.||.|.....|::.||..|:|:|.|.:||:||..|.:::.:::::.....|::.||||.||..
Human   141 REAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTF 205

  Fly   687 SVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQCNGT-------------TAAALDQS 738
            |||||:|||.|.|:...||||||:.|.|.:|||:|||..:...:             :|.||:..
Human   206 SVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMV 270

  Fly   739 IASSGDVWGLLQPFAHLNAGRIASGALALPRWANSLDQVIASSGDFRGH---------------- 787
            |.:..::||:|||:.||..|:.|:|.|:||.:.:..      :|...||
Human   271 INNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPY------NGGSLGHDERADAYAQLELRTLE 329

  Fly   788 ---LATCVGSIRELKEKALRTQQEFQLAAAL-------------------SGSALAALFYFMRCS 830
               ||||||||.||.:...|.....|....|                   |..||..|:||:||.
Human   330 QSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCP 394

  Fly   831 QLEHTELLAASGCHAGQAQSAAPGGGTSSAGHHVQELCYERAYVVLPPLAEWLRVAAAHAEHRNA 895
            |:|..|           ..:..|...|         |..||.:::||||.||:|||..:||||.:
Human   395 QMESME-----------NPNLDPPRMT---------LNNERPFMLLPPLMEWMRVAITYAEHRRS 439

  Fly   896 MMIDKDDVMQAARLLLPGVDCPIRPV--AH--------DEELPTKKTHFNTAPTVSSTGTGTGSS 950
            :.:|..|:.|||||||||:||..|.:  .|        |....|:|  ||
Human   440 LTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEK--FN--------------- 487

  Fly   951 SCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTA 1015
                              .:||        |::|..||.:|:.||.:.|.| ...:|.:..|:|.
Human   488 ------------------QDLG--------FRMLNCGRTDLINQAIEALGP-DGVNTMDDQGMTP 525

  Fly  1016 LMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPAIQPDTQHWTALSFAASRANYVALRILLE 1080
            ||.|....||..:..|:|||.:.:::| |:.|..:|:|.||::|||:|:||....:...:::||:
Human   526 LMYACAAGDEAMVQMLIDAGANLDIQV-PSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD 589

  Fly  1081 RGGKVEGGA-RSSEEKCTLTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSLCFAGSAQKGCF 1144
            .|..|||.| ...|:....||||||:..||.|:|:|||:.||:..||..:...:..:......||
Human   590 AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCF 654

  Fly  1145 CAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLAEGDVGGVRGSGGPTGAGGPNSASASGN 1209
               |.:||||||:.||||||.| .....|||||||:|||    ||..|          .||:.|:
Human   655 ---SHSAAHGHRNVLRKLLTQP-QQAKADVLSLEEILAE----GVEES----------DASSQGS 701

  Fly  1210 NEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWMHALSAAHDLRLDAVIDQ 1274
            ..:....|::|:.|.||||||:|||:.::|||:|||.|||||.||.|:.:|..:......:|:..
Human   702 GSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQS 766

  Fly  1275 LLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGTTLLLADIFATCFGWETLPPVKEQPPMQP 1338
            ||:||..:..::|:.:.|:|.|.|:|:|.: :||:.....||.||..|:|...:|.:   |.::.
Human   767 LLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSI---PEIRK 828

  Fly  1339 VQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKL-SEGSSTPTVQINDI 1402
            ...:|:||.|:||.|:|||||.||||:||.||::|||||.||::::::|. .:|.|:.|::|:|:
Human   829 TLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDM 893

  Fly  1403 RYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVAMYIH 1467
            :|||||::||:||.||..|:::...|:|||::|||.|||:.|.|:.|..||:.:.:::.|..|.:
Human   894 KYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKY 958

  Fly  1468 AKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAK--KIPNHDVLAGLLQTLQNRL 1524
            ||::||..|..||:.|.|::|.|||. .|:.::|::.:  |:...|.|..|..||..|:
Human   959 AKIHNAPELALFCEGFFLKHMKALLE-QDAFRQLIYGRSSKVQGLDPLQDLQNTLAERV 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	30/52 (58%)
		ANK	1006..1163	CDD:238125	62/157 (39%)
		ANK repeat	1012..1056	CDD:293786	16/43 (37%)
		Ank_2	1016..1122	CDD:289560	44/106 (42%)
		ANK repeat	1058..1091	CDD:293786	13/33 (39%)
		ANK repeat	1093..1121	CDD:293786	14/27 (52%)
		ANK repeat	1141..1173	CDD:293786	16/31 (52%)
		BTB	1350..1446	CDD:279045	52/96 (54%)
		BTB	1356..1449	CDD:197585	49/93 (53%)
		SPOP_C_like	1456..>1492	CDD:269810	13/35 (37%)
ABTB2	NP_665803.2	H2A	194..>242	CDD:305064	28/47 (60%)
		Ank_4	<498..542	CDD:290365	15/44 (34%)
		ANK	516..670	CDD:238125	62/157 (39%)
		ANK 1	521..550		11/28 (39%)
		ANK repeat	524..565	CDD:293786	15/41 (37%)
		Ank_2	526..633	CDD:289560	45/107 (42%)
		ANK repeat	567..604	CDD:293786	13/36 (36%)
		ANK 2	567..596		10/28 (36%)
		ANK 3	606..635		15/28 (54%)
		ANK repeat	606..631	CDD:293786	13/24 (54%)
		ANK repeat	649..679	CDD:293786	16/33 (48%)
		ANK 4	649..678		16/32 (50%)
		BTB	837..940	CDD:279045	54/102 (53%)
		BTB	846..947	CDD:197585	52/100 (52%)
		SPOP_C_like	947..>991	CDD:269810	16/44 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4858
eggNOG	1	0.900	-	-		E1_28KA7
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15904
Inparanoid	1	1.050	598	1.000	Inparanoid score	I964
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49645
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm41605
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	LDO	PTHR46071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5139
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870