DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and BTBD11

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001018082.1	Gene:	BTBD11 / 121551	HGNCID:	23844	Length:	1104	Species:	Homo sapiens

Alignment Length:	1193	Identity:	408/1193 - (34%)
Similarity:	586/1193 - (49%)	Gaps:	251/1193 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 GKAPWSGTGLEDIKLAMLTLRS----QTSSSTYSSLSAGSESSEPARRLG-------------RY 548
            ||.|...| |||     |||.|    ...|...|:||.....|.||...|             |:
Human     5 GKKPVVRT-LED-----LTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMHSRH 63

  Fly   549 SSLETVVTSTSADE--FVWVDSH-NRLV-ELQHPPWSQQCILKVLRNGRCQQQAE----HLAVEA 605
            :|.:||.|:...|.  ......| :||: :|...||:.|.:..:|...|..:...    .|..:|
Human    64 NSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELEALLLRSRDPRAGPAVPGGLPKDA 128

  Fly   606 VSRLGYLLQRALVRIAREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMF--AV 668
            :::|..|:.|||||||:|.||.|.....|:|.|:..|:.:|||..||..||.|.|.:.:::  :.
Human   129 LAKLSTLVSRALVRIAKEAQRLSLRFAKCTKYEIQSAMEIVLSWGLAAHCTAAALAALSLYNMSS 193

  Fly   669 PGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI---------A 724
            .|...|.:.||||.||..||||.||||.|:|:...|||:||:||.|.:|:|..:|         .
Human   194 AGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVVASGVP 258

  Fly   725 LQCNGT----------------------------------------------------------- 730
            ..|:|.
Human   259 RSCSGPGSGSGSGPGPSSGPGAAPAADKEREAPGGGAASGGACSAASSASGGSSCCAPPAAAAAA 323

  Fly   731 -----------------------TAAALDQSIASSGDVWGLLQPFAHLNAGRIASGALALPRWAN 772
                                   |...|:.::.:..::||||||:.||..|:.|||.|.||   :
Human   324 VPPAAAANHHHHHHHALHEAPKFTVETLEHTVNNDSEIWGLLQPYQHLICGKNASGVLCLP---D 385

  Fly   773 SL-------------DQVIASSGDFR----GHLATCVGSIRELKEKALRTQQEFQ-LAAALSGS- 818
            ||             :..:.|..:.|    ..|||.||||.||.:...|.....| |.|...|:
Human   386 SLNLHRDPQRSNKPGELPMFSQSELRTIEQSLLATRVGSIAELSDLVSRAMHHLQPLNAKHHGNG 450

  Fly   819 ---------------ALAALFYFMRCSQLEHTELLAASGCHAGQAQSAAPGGGTSSAGHHVQELC 868
                           ||..|.|||.|.|:|...                |....|.....|
Human   451 TPLHHKQGALYWEPEALYTLCYFMHCPQMEWEN----------------PNVEPSKVNLQV---- 495

  Fly   869 YERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKDDVMQAARLLLPGVDCPIRPVAHDEELPTKKTH 933
             ||.::|||||.||:|||.|||.||.:..:|.|||.||||||||||||..|.:..|:
Human   496 -ERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADD-------- 551

  Fly   934 FNTAPTVSSTGTGTGSSSCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQL 998
                            ..|:|..:..:.|       |...:..:|  |::|..||.:|:.||..|
Human   552 ----------------CFCASRKLDAVAI-------EAKFKQDLG--FRMLNCGRTDLVKQAVSL 591

  Fly   999 LPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPAIQPDTQHWTAL 1063
            |.| ...:|.:..|:|.||.|.:|.||..:..|||||.|.||||...... ||::.|:|:|||||
Human   592 LGP-DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHK-YPSVHPETRHWTAL 654

  Fly  1064 SFAASRANYVALRILLERGGKVEGGARSSEEKCTLTPLQLAAGTGNLEIVALLLAHGANAFLSTQ 1128
            :||....:...:::||:.|.||||.....||..:.|||||||..||.|:|:|||..||:..:.|.
Human   655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTM 719

  Fly  1129 QKDSLCFAGSAQKGCFCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLAEG-DVGGVRGS 1192
            .::.:   .:..:|...:.|.|||||||:..||||..|....: |:|||||:|||| |:...
Human   720 YRNGI---STTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS-DILSLEEILAEGTDLAET--- 777

  Fly  1193 GGPTGAGGPNSASASGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWM 1257
                   .|....||.|        :|.:::.|:||||||||:.::|:||::|.:|||||||.|:
Human   778 -------APPPLCASRN--------SKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWL 827

  Fly  1258 HALSAAHDLRLDAVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGTTLLLADIFATC 1321
            .:|..|.......:|..||::|..:..::|:.:.|::.|||:|.|.: :|||..:..|..||..|
Human   828 ESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHC 892

  Fly  1322 FGWETLPPVKEQPPMQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSS 1386
            :|...:|.:.|   ::..|.||:||.|:||.|:|||||.|||:.||.||::|.||||||:::|||
Human   893 YGPYPIPKLTE---IKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS 954

  Fly  1387 K-LSEGSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEA 1450
            | .::|:   .::|..::|.|||||||:||.||..||.:.:.:::||::||.|||||.|.|:.|.
Human   955 KPTNDGT---CIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEI 1016

  Fly  1451 RCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAK--KIPNHDVL 1513
            .|::.::.||.|.:|.|||......|..:|:.:.|:||:.|:. :::.|:||:.|  :....|||
Human  1017 ICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIE-NEAFKQLLYDKNGEGTGQDVL 1080

  Fly  1514 AGLLQTLQNRLKARKPNSGGGLV 1536
            ..|.:||..|:::...:|..|.|
Human  1081 QDLQRTLAIRIQSIHLSSSKGSV 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	27/61 (44%)
		ANK	1006..1163	CDD:238125	67/156 (43%)
		ANK repeat	1012..1056	CDD:293786	20/43 (47%)
		Ank_2	1016..1122	CDD:289560	51/105 (49%)
		ANK repeat	1058..1091	CDD:293786	14/32 (44%)
		ANK repeat	1093..1121	CDD:293786	16/27 (59%)
		ANK repeat	1141..1173	CDD:293786	14/31 (45%)
		BTB	1350..1446	CDD:279045	52/96 (54%)
		BTB	1356..1449	CDD:197585	49/93 (53%)
		SPOP_C_like	1456..>1492	CDD:269810	12/35 (34%)
BTBD11	NP_001018082.1	H2A	200..>244	CDD:305064	25/43 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..301		2/40 (5%)
		Ank_4	<580..624	CDD:290365	17/44 (39%)
		ANK	598..751	CDD:238125	67/156 (43%)
		ANK 1	603..632		14/28 (50%)
		ANK repeat	606..647	CDD:293786	19/41 (46%)
		Ank_2	608..716	CDD:289560	52/108 (48%)
		ANK repeat	649..680	CDD:293786	14/30 (47%)
		ANK 2	649..678		12/28 (43%)
		ANK repeat	682..712	CDD:293786	16/29 (55%)
		ANK 3	687..716		16/28 (57%)
		Ank_2	692..>752	CDD:289560	27/62 (44%)
		ANK 4	730..759		14/28 (50%)
		ANK 5	825..854		7/28 (25%)
		BTB	915..1018	CDD:279045	55/105 (52%)
		BTB	924..1022	CDD:197585	51/100 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4858
eggNOG	1	0.900	-	-		E1_28KA7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I964
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49645
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm41605
orthoMCL	1	0.900	-	-		OOG6_105756
Panther	1	1.100	-	-	O	PTHR46071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840