Protein Alignment CG43980 and ABTB3

DIOPT Version :10

• Sequence 1: NP_001262185.1
• Gene: CG43980 / 2768995
• FlyBaseID: FBgn0264711
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001018082.1
• Gene: ABTB3 / 121551
• HGNCID: 23844
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 1193
• Identity: 408/1193 - (34%)
• Similarity: 586/1193 - (49%)
• Gaps: 251/1193 - (21%)

  Fly   501 GKAPWSGTGLEDIKLAMLTLRS----QTSSSTYSSLSAGSESSEPARRLG-------------RY 548
            ||.|...| |||     |||.|    ...|...|:||.....|.||...|             |:
Human     5 GKKPVVRT-LED-----LTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMHSRH 63

  Fly   549 SSLETVVTSTSADE--FVWVDSH-NRLV-ELQHPPWSQQCILKVLRNGRCQQQAE----HLAVEA 605
            :|.:||.|:...|.  ......| :||: :|...||:.|.:..:|...|..:...    .|..:|
Human    64 NSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELEALLLRSRDPRAGPAVPGGLPKDA 128

  Fly   606 VSRLGYLLQRALVRIAREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMF--AV 668
            :::|..|:.|||||||:|.||.|.....|:|.|:..|:.:|||..||..||.|.|.:.:::  :.
Human   129 LAKLSTLVSRALVRIAKEAQRLSLRFAKCTKYEIQSAMEIVLSWGLAAHCTAAALAALSLYNMSS 193

  Fly   669 PGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI---------A 724
            .|...|.:.||||.||..||||.||||.|:|:...|||:||:||.|.:|:|..:|         .
Human   194 AGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVVASGVP 258

  Fly   725 LQCNGT----------------------------------------------------------- 730
            ..|:|.
Human   259 RSCSGPGSGSGSGPGPSSGPGAAPAADKEREAPGGGAASGGACSAASSASGGSSCCAPPAAAAAA 323

  Fly   731 -----------------------TAAALDQSIASSGDVWGLLQPFAHLNAGRIASGALALPRWAN 772
                                   |...|:.::.:..::||||||:.||..|:.|||.|.||   :
Human   324 VPPAAAANHHHHHHHALHEAPKFTVETLEHTVNNDSEIWGLLQPYQHLICGKNASGVLCLP---D 385

  Fly   773 SL-------------DQVIASSGDFR----GHLATCVGSIRELKEKALRTQQEFQ-LAAALSGS- 818
            ||             :..:.|..:.|    ..|||.||||.||.:...|.....| |.|...|:
Human   386 SLNLHRDPQRSNKPGELPMFSQSELRTIEQSLLATRVGSIAELSDLVSRAMHHLQPLNAKHHGNG 450

  Fly   819 ---------------ALAALFYFMRCSQLEHTELLAASGCHAGQAQSAAPGGGTSSAGHHVQELC 868
                           ||..|.|||.|.|:|...                |....|.....|
Human   451 TPLHHKQGALYWEPEALYTLCYFMHCPQMEWEN----------------PNVEPSKVNLQV---- 495

  Fly   869 YERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKDDVMQAARLLLPGVDCPIRPVAHDEELPTKKTH 933
             ||.::|||||.||:|||.|||.||.:..:|.|||.||||||||||||..|.:..|:
Human   496 -ERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADD-------- 551

  Fly   934 FNTAPTVSSTGTGTGSSSCSSPVVSGIGIGIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQL 998
                            ..|:|..:..:.|       |...:..:|  |::|..||.:|:.||..|
Human   552 ----------------CFCASRKLDAVAI-------EAKFKQDLG--FRMLNCGRTDLVKQAVSL 591

  Fly   999 LPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVPPAGSAGYPAIQPDTQHWTAL 1063
            |.| ...:|.:..|:|.||.|.:|.||..:..|||||.|.||||...... ||::.|:|:|||||
Human   592 LGP-DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHK-YPSVHPETRHWTAL 654

  Fly  1064 SFAASRANYVALRILLERGGKVEGGARSSEEKCTLTPLQLAAGTGNLEIVALLLAHGANAFLSTQ 1128
            :||....:...:::||:.|.||||.....||..:.|||||||..||.|:|:|||..||:..:.|.
Human   655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTM 719

  Fly  1129 QKDSLCFAGSAQKGCFCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLAEG-DVGGVRGS 1192
            .::.:   .:..:|...:.|.|||||||:..||||..|....: |:|||||:|||| |:...
Human   720 YRNGI---STTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS-DILSLEEILAEGTDLAET--- 777

  Fly  1193 GGPTGAGGPNSASASGNNEDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWM 1257
                   .|....||.|        :|.:::.|:||||||||:.::|:||::|.:|||||||.|:
Human   778 -------APPPLCASRN--------SKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWL 827

  Fly  1258 HALSAAHDLRLDAVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFR-NKNEGTTLLLADIFATC 1321
            .:|..|.......:|..||::|..:..::|:.:.|::.|||:|.|.: :|||..:..|..||..|
Human   828 ESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHC 892

  Fly  1322 FGWETLPPVKEQPPMQPVQGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSS 1386
            :|...:|.:.|   ::..|.||:||.|:||.|:|||||.|||:.||.||::|.||||||:::|||
Human   893 YGPYPIPKLTE---IKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS 954

  Fly  1387 K-LSEGSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEA 1450
            | .::|:   .::|..::|.|||||||:||.||..||.:.:.:::||::||.|||||.|.|:.|.
Human   955 KPTNDGT---CIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEI 1016

  Fly  1451 RCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAK--KIPNHDVL 1513
            .|::.::.||.|.:|.|||......|..:|:.:.|:||:.|:. :::.|:||:.|  :....|||
Human  1017 ICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIE-NEAFKQLLYDKNGEGTGQDVL 1080

  Fly  1514 AGLLQTLQNRLKARKPNSGGGLV 1536
            ..|.:||..|:::...:|..|.|
Human  1081 QDLQRTLAIRIQSIHLSSSKGSV 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Atrophin-1	<270..>428	CDD:460830
		HFD_ABTB2-like	668..763	CDD:467038	43/185 (23%)
		ANKYR	983..>1173	CDD:440430	79/189 (42%)
		ANK repeat	1012..1056	CDD:293786	20/43 (47%)
		ANK repeat	1058..1091	CDD:293786	14/32 (44%)
		ANK repeat	1093..1121	CDD:293786	16/27 (59%)
		ANK repeat	1141..1173	CDD:293786	14/31 (45%)
		BTB_POZ_ABTB2-like	1343..1460	CDD:349606	59/117 (50%)
		BACK_ABTB2_like	1456..1527	CDD:350566	24/72 (33%)
ABTB3	NP_001018082.1	HFD_ABTB2-like	193..379	CDD:467038	43/185 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..301		2/40 (5%)
		ANKYR	<580..753	CDD:440430	77/177 (44%)
		ANK 1. /evidence=ECO:0000255	603..632		14/28 (50%)
		ANK repeat	606..647	CDD:293786	19/41 (46%)
		ANK repeat	649..680	CDD:293786	14/30 (47%)
		ANK 2. /evidence=ECO:0000255	649..678		12/28 (43%)
		ANK repeat	682..712	CDD:293786	16/29 (55%)
		ANK 3. /evidence=ECO:0000255	687..716		16/28 (57%)
		ANK 4. /evidence=ECO:0000255	730..759		14/28 (50%)
		ANK 5. /evidence=ECO:0000255	825..854		7/28 (25%)
		BTB_POZ_BTBD11	899..1029	CDD:349660	65/135 (48%)
		BACK_BTBD11	1022..1104	CDD:350602	27/83 (33%)