DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43980 and btbd11

DIOPT Version :9

Sequence 1:	NP_001262185.1	Gene:	CG43980 / 2768995	FlyBaseID:	FBgn0264711	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_002938736.2	Gene:	btbd11 / 100490895	XenbaseID:	XB-GENE-991957	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	1093	Identity:	396/1093 - (36%)
Similarity:	592/1093 - (54%)	Gaps:	157/1093 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 KLAMLTLRSQTSSSTY---------SSLSAGSESSEPARRLG------------RYSSLETVVTS 557
            |.|:.||...|..|.|         |:||..|:|...|...|            |::|.:||.|.
Frog     6 KRAVRTLEDLTLDSGYGGAADSIRSSNLSLCSDSHPVAYVHGGNCWHLTDSMHSRHNSFDTVNTV 70

  Fly   558 TSADEFVWVDSH---NRLVELQHPPWSQQCILKVLRNGRCQQQAEHLAVEAVSRLGYLLQRALVR 619
            .:.|..| :|..   :||.:|:..|||.:.:..:|:.   :|.....:.:.:|:|..|:.|||||
Frog    71 LAEDSEV-LDCSGQCSRLPDLEEVPWSIEELEALLKK---EQMVVGASRDVLSKLSALVSRALVR 131

  Fly   620 IAREIQRFSAGVGLCSKQEVVGALRVVLSSSLADSCTKACLRSAAMFAVPGESALKQSKSARAGL 684
            ||:|.||.|.....|:|.|:..|:.:||:.|||.|||.:.|.:.:::.:.....|.:.||.|.||
Frog   132 IAKEAQRLSLRFAKCTKYEIQSAMEIVLAWSLASSCTASALSALSLYNMSTTDRLSRGKSVRCGL 196

  Fly   685 QLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI------------ALQCNGTTAAALDQ 737
            ..|||:|||||.|:|:...|||:||:|:...:|.|.:||            ..:....||.:::|
Frog   197 TFSVGKFYRWMVDSRVALRIHEHAAIYVTGCMETLFKEIYKRVLSMPRPEKENEAPNFTAESMEQ 261

  Fly   738 SIASSGDVWGLLQPFAHLNAGRIASGALALPRWAN----------SLDQVIASSGDFR----GHL 788
            :|.:..::|||||||.||..|:.|||.|.||...|          ..|..:.|..:.|    ..|
Frog   262 AINNDSELWGLLQPFQHLICGKNASGVLCLPDTLNLHREQQRSNKPGDVQMFSQSELRTIEQSLL 326

  Fly   789 ATCVGSIRELKEKALRTQQEFQ-LAAALSGS----------------ALAALFYFMRCSQLEHTE 836
            ||.||||.||.:...|.....| |.:...|:                ||..|.|||.|.|:|.
Frog   327 ATRVGSIAELSDLVSRAMHHLQPLNSKQHGNGTPMHHKQGPLYWEPEALYTLCYFMHCPQMEF-- 389

  Fly   837 LLAASGCHAGQAQSAAPGGGTSSAGHHVQELCYERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKD 901
                      :..:..|...|         |..||.:::||||.||:|||.|||.:|.:..:|.|
Frog   390 ----------ENPNVEPSKVT---------LQTERPFLMLPPLMEWIRVAVAHAGYRRSFSVDSD 435

  Fly   902 DVMQAARLLLPGVDCPIRPVAHDEELPTKKTHFNTAPTVSSTGTGTGSSSCSSPVVSGIGIGIGE 966
            ||.||||||||||||..|.:..|:                        ..|:|..:..:
Frog   436 DVRQAARLLLPGVDCEPRQLKADD------------------------CFCASRKLDAV------ 470

  Fly   967 DTSELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHAL 1031
             .:|...:..:|  |::|..||.:|:.||..||.| ...::.:..|:|.||.|.:|.||..:..|
Frog   471 -ATEAKFKQDLG--FRMLNCGRTDLVKQAVSLLGP-DGINSMSEQGMTPLMYACVRGDEAMVQML 531

  Fly  1032 LDAGCDPNVEVPPAGSAGYPAIQPDTQHWTALSFAASRANYVALRILLERGGKVEGGARSSEEKC 1096
            ||||.:.|||||..... .|::.|:|:|||||:||..:.:...:::||:.|..|||...:.||..
Frog   532 LDAGAELNVEVPITAHK-CPSVHPETRHWTALTFAVLQGHIPVVQLLLDAGANVEGSLEAGEENY 595

  Fly  1097 TLTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSLCFAGSAQKGCFCAISVAAAHGHRSCLRK 1161
            :.|||||||..||.|:.:|||..|.:..:.|..::.:   .:|.:|...:.|.|||||||:..||
Frog   596 SETPLQLAAAAGNFELASLLLERGGDPMIGTMYRNGI---STAPQGDMNSFSQAAAHGHRNVFRK 657

  Fly  1162 LLTHPVSPGTRDVLSLEEMLAEGDVGGVRGSGGPTGAGGPNSASASGNNEDILPLLNKTQIKRLQ 1226
            ||..|....: |:|||||:|||       ||..|.....|..:|.:          :|.::|.|:
Frog   658 LLAQPEKEKS-DILSLEEILAE-------GSDLPDTTQTPFCSSRN----------SKAKLKALK 704

  Fly  1227 EAMYHSAENNHLDITIELRKLGVPWTLHCWMHALSAAHDLRLDAVIDQLLQDFLQVCPDDYSAQF 1291
            ||||||||:.::||||::|.||||||||.|:.:|..:.......:|..||::|..:..::|:.:.
Frog   705 EAMYHSAEHGYVDITIDIRSLGVPWTLHTWLESLRISFQQHRRPLIQCLLKEFKSIQEEEYTEEL 769

  Fly  1292 VSECLPLLFNIFR-NKNEGTTLLLADIFATCFGWETLPPVKEQPPMQPVQGSRIDPKFVNNPELS 1355
            :::.|||:|.|.: :|||..:..||.||:.|:|...:|.:.|   ::..|.||:||:|:||.|:|
Frog   770 ITQGLPLMFEILKASKNEVISQQLAVIFSQCYGPYPIPKLTE---IKRKQTSRLDPQFLNNKEMS 831

  Fly  1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGGCS 1420
            |:||.|||:.||.||::|.||||||:::|::|.|..:|  .::||.::|||||||||:|||||..
Frog   832 DITFIVEGRPFYAHKVLLFTASPRFKALLTNKSSAENS--CIEINYVKYHIFQLVMQYLYCGGTE 894

  Fly  1421 SLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLL 1485
            ||.:.:.:::||::||.|||||.|.|:.|..|::.::.:|.|.:|.|||...|..|..:|:.:.|
Frog   895 SLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCVDIYNHAKFLGAPELSSYCEGYFL 959

  Fly  1486 QNMVALLTYDDSVKRLLFAK--KIPNHDVLAGLLQTLQNRLKARKPNSGGGLV 1536
            :||: ||..:|:.|:||:.|  :....|||..|.:||..|:::...:|..|.:
Frog   960 KNMM-LLIENDAFKQLLYDKNGETTGQDVLGDLQRTLATRIQSIHLSSSKGSI 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43980	NP_001262185.1	Med25_SD1	265..424	CDD:288132
		H2A	675..>728	CDD:305064	25/64 (39%)
		ANK	1006..1163	CDD:238125	63/156 (40%)
		ANK repeat	1012..1056	CDD:293786	19/43 (44%)
		Ank_2	1016..1122	CDD:289560	48/105 (46%)
		ANK repeat	1058..1091	CDD:293786	13/32 (41%)
		ANK repeat	1093..1121	CDD:293786	15/27 (56%)
		ANK repeat	1141..1173	CDD:293786	14/31 (45%)
		BTB	1350..1446	CDD:279045	53/95 (56%)
		BTB	1356..1449	CDD:197585	50/92 (54%)
		SPOP_C_like	1456..>1492	CDD:269810	12/35 (34%)
btbd11	XP_002938736.2	HTA1	185..>273	CDD:227587	32/87 (37%)
		Ank_2	<488..540	CDD:372319	21/52 (40%)
		ANK repeat	514..555	CDD:293786	18/41 (44%)
		Ank_2	516..624	CDD:372319	48/108 (44%)
		ANK repeat	557..594	CDD:293786	14/36 (39%)
		ANK repeat	596..620	CDD:293786	13/23 (57%)
		BTB_POZ	807..937	CDD:365784	65/134 (49%)
		BACK_BTBD11	930..1012	CDD:350602	28/83 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	604	1.000	Inparanoid score	I923
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201821at33208
OrthoFinder	1	1.000	-	-		FOG0002685
OrthoInspector	1	1.000	-	-		otm48823
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060