Protein Alignment Muc68E and Rtn4

DIOPT Version :9

• Sequence 1: NP_996064.1
• Gene: Muc68E / 2768990
• FlyBaseID: FBgn0053265
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_918943.1
• Gene: Rtn4 / 68585
• MGIID: 1915835
• Length: 1162
• Species: Mus musculus
• Alignment Length: 1133
• Identity: 223/1133 - (19%)
• Similarity: 368/1133 - (32%)
• Gaps: 312/1133 - (27%)

  Fly   427 DSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQETT 491
            ||.|.|..:  ...:...:||.....||:         |:.|||..:|:...:..:.........
Mouse    15 DSPPRPPPA--FKYQFVTEPEDEEDEEDE---------EEEEDDEDLEELEVLERKPAAGLSAAP 68

  Fly   492 YDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDPEGSTTREDDTT--- 553
            ..|..:                 |..|.:::...|.|......|..|..:.:.|..|....:
Mouse    69 VPPAAA-----------------PLLDFSSDSVPPAPRGPLPAAPPTAPERQPSWERSPAASAPS 116

  Fly   554 ---VAIETTTEKPEDD------TTAEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTE 609
               .|....::.||||      .....::|:.|.:...:........||.: .|:|..|:...:|
Mouse   117 LPPAAAVLPSKLPEDDEPPARPPAPAGASPLAEPAAPPSTPAAPKRRGSGS-VDETLFALPAASE 180

  Fly   610 KREDDTTVEDSTPIPEESTTVAQDTTNDPEGSTT---REDDTTVAIETTTEKPEDDTTAEDSTPI 671
                        |:...|.....|....| |:|.   :||..:|..||....|       ..:|:
Mouse   181 ------------PVIPSSAEKIMDLKEQP-GNTVSSGQEDFPSVLFETAASLP-------SLSPL 225

  Fly   672 PEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTT--VAQETT--- 731
               ||...:|..|....|.....:.|:          ::|..|.|..:||.:|.  |.:|:.
Mouse   226 ---STVSFKEHGYLGNLSAVASTEGTI----------EETLNEASRELPERATNPFVNRESAEFS 277

  Fly   732 ---YDPEGST---TREDDTTVAIETTTE------KPEDDTTAEDSTPIPEES-----TTVAQDTT 779
               |...||:   :.:.::.:.:|.|.|      |.::|.....:...|:||     ..|.:|..
Mouse   278 VLEYSEMGSSFNGSPKGESAMLVENTKEEVIVRSKDKEDLVCSAALHNPQESPATLTKVVKEDGV 342

  Fly   780 NDPEG-------------STTRED--------------DT------TVAIETTTEKREDDTTVED 811
            ..||.             :..||:              ||      .:|.....|.:.|....||
Mouse   343 MSPEKTMDIFNEMKMSVVAPVREEYADFKPFEQAWEVKDTYEGSRDVLAARANMESKVDKKCFED 407

  Fly   812 STPIPEETTTVGQETTYDPEGSTTREEDTTVAIETTTEKPEDDTTAE---DSTPIPEESTTVAQE 873
            |.    |....|::       |.:|.|:  .:...|.|..:|.:.|.   ||.....|||.....
Mouse   408 SL----EQKGHGKD-------SESRNEN--ASFPRTPELVKDGSRAYITCDSFSSATESTAANIF 459

  Fly   874 TTYDPEGSTTREDDTTVAMETTTEKREDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREEDTTV 938
            ...:...|..:.|:..:      |:|:.....|.::|.......||   .:|.|......::.:.
Mouse   460 PVLEDHTSENKTDEKKI------EERKAQIITEKTSPKTSNPFLVA---IHDSEADYVTTDNLSK 515

  Fly   939 AIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDPEGSTTREDDTTVAIDTTTEKPEDDTTVED 1003
            ..|....     |..|..||      .:.||..   |........|.:|.:|..:      .|:.
Mouse   516 VTEAVVA-----TMPEGLTP------DLVQEAC---ESELNEATGTKIAYETKVD------LVQT 560

  Fly  1004 STPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTIAQET-- 1066
            |..|.|.....||...:..|...|   .:.|..|...|.|.:..       :|....::||.:
Mouse   561 SEAIQESIYPTAQLCPSFEEAEAT---PSPVLPDIVMEAPLNSL-------LPSTGASVAQPSAS 615

  Fly  1067 --------TYD-----PEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQD----- 1113
                    :||     ||.....|:..:||::|:..|.|    :::    ||.....||:
Mouse   616 PLEVPSPVSYDGIKLEPENPPPYEEAMSVALKTSDSKEE----IKE----PESFNAAAQEAEAPY 672

  Fly  1114 --------------TTNDPEGSTTREDDTTVAIDTTTEK--PEDDTTVEDSTPIPEESTTVAQDT 1162
                          |...||.|...|    :|   ..||  |:....|:||:|..|.....:.|:
Mouse   673 ISIACDLIKETKLSTEPSPEFSNYSE----IA---KFEKSVPDHCELVDDSSPESEPVDLFSDDS 730

  Fly  1163 TNDPEGSTTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQE--TTYDPEGSTTREDDTT 1225
            .  ||...|:||...:..|:.||..|..|..:....:......||:.  .::.|....|: |..:
Mouse   731 I--PEVPQTQEEAVMLMKESLTEVSETVTQHKHKERLSASPQEVGKPYLESFQPNLHITK-DAAS 792

  Fly  1226 VAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVE 1290
            ..|.|.|:|    .|:  |..:.|.:|.:..:            ||   .:.:..:|.::..|..
Mouse   793 NEIPTLTKK----ETI--SLQMEEFNTAIYSN------------DD---LLSSKEDKMKESETFS 836

  Fly  1291 DSTPIP--EESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVE---DSTPIPEESTTI 1350
            ||:||.  :|..|......:.|:..|          |.......:...|:   :|.|..|....:
Mouse   837 DSSPIEIIDEFPTFVSAKDDSPKEYT----------DLEVSNKSEIANVQSGANSLPCSELPCDL 891

  Fly  1351 AQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDS--------TPIPEESTTVAQDTTNDPE 1407
            :.:.||                      |:|:..|.|.        :.:|.....|:...:....
Mouse   892 SFKNTY----------------------PKDEAHVSDEFSKSRSSVSKVPLLLPNVSALESQIEM 934

  Fly  1408 GSTTREEDTTVAIETTTEKPEDDTTVED 1435
            |:..:.:..|...|   ||...||..||
Mouse   935 GNIVKPKVLTKEAE---EKLPSDTEKED 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696
		ChtBD2	1688..1734	CDD:214696
Rtn4	NP_918943.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..183		36/208 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..432		9/38 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..730		5/18 (28%)
		Reticulon	975..1139	CDD:280592

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000