DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc68E and ZNF512B

DIOPT Version :9

Sequence 1:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_024307718.1	Gene:	ZNF512B / 57473	HGNCID:	29212	Length:	1084	Species:	Homo sapiens

Alignment Length:	701	Identity:	138/701 - (19%)
Similarity:	186/701 - (26%)	Gaps:	253/701 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1121 STTREDDTTVAIDTTTEKP-EDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREEDTTVAIETTT 1184
            |..|....|.||..|...| ....||  |.|:|                 .|:....|..|..|.
Human   231 SVGRPMPVTKAIPVTRPVPVTKPVTV--SRPMP-----------------VTKAMPVTKPITVTK 276

  Fly  1185 EKPEDDTTVEDSTPIPEETTTVGQETTYDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPI-- 1247
            ..|     |....|:.:..|.....|...|...|   ...||:......||     |..|.||
Human   277 SVP-----VTKPVPVTKPITVTKLVTVTKPVPVT---KPVTVSRPIVVSKP-----VTVSRPIAI 328

  Fly  1248 ----PEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEEST-------- 1300
                |.....:...:.|....:|.|......|.|:.           |:.|||.:..
Human   329 SRHTPPCKMVLLTRSENKAPRATGRNSGKKRAADSL-----------DTCPIPPKQARPENGEYG 382

  Fly  1301 ----------TVAQDTTNDPEGSTTREDDTTVAIDTT--TEKPEDDT-----TVEDSTP--IPEE 1346
                      .::.||::......:|......|:...  ...||:|.     ..:..||  ...|
Human   383 PSSMGQSSAFQLSADTSSGSLSPGSRPSGGMEALKAAGPASPPEEDPERTKHRRKQKTPKKFTGE 447

  Fly  1347 STTIAQETTYDPEGSTTREDDTTVAIETTTE--KPED--------DTTVEDSTPIPEESTTVAQD 1401
            ..:|:  .|:..:|....||...|......|  .|||        ..||....|.|     ||..
Human   448 QPSIS--GTFGLKGLVKAEDKARVHRSKKQEGPGPEDARKKVPAAPITVSKEAPAP-----VAHP 505

  Fly  1402 TTNDPEGSTTR----------------EEDTTVAIETTTE---KPED------------------ 1429
            ....||....|                ...|.|.::...|   |.:|
Human   506 APGGPEEQWQRAIHERGEAVCPTCNVVTRKTLVGLKKHMEVCQKLQDALKCQHCRKQFKSKAGLN 570

  Fly  1430 -DTTVEDST-PIPEETTTVGQETTYD--------------PE----------------------- 1455
             .|..|.|. |...|.:..|::...:              |:
Human   571 YHTMAEHSAKPSDAEASEGGEQEERERLRKVLKQMGRLRCPQEGCGAAFSSLMGYQYHQRRCGKP 635

  Fly  1456 --------------GSTTRE---DDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVAQETTYDPE 1503
                          |.|.|.   .|..|..|.|...||:.|   |.:|..|:...|  |.|  |.
Human   636 PCEVDSPSFPCTHCGKTYRSKAGHDYHVRSEHTAPPPEEPT---DKSPEAEDPLGV--ERT--PS 693

  Fly  1504 GSTTRDDTTVAIETTTEKPEDDTTAEGSTPIPDTSTTVNQDTTTDESSTVVTTTNIPKESTTLGD 1568
            |...|....||:....|..||:...:.      |...:..|...:.:....|...:|    ||..
Human   694 GRVRRTSAQVAVFHLQEIAEDELARDW------TKRRMKDDLVPETARLNYTRPGLP----TLNP 748

  Fly  1569 STLSPGENS----------------------------------TAGQVSTSTTLVYDTTSSP--- 1596
            ..|...:|.                                  ::|...|:........|||
Human   749 QLLEAWKNEVKEKGHVNCPNDCCEAIYSSVSGLKAHLASCSKVSSGACPTARCAALRAPSSPHAG 813

  Fly  1597 IPSSSRSTTLEP------SSSSSPETTTSSLPPLSCSTGYQYLPHPTNCHK 1641
            .|.||....|.|      |||::|||...    |..|.|  :||.|...||
Human   814 FPHSSEGPCLVPYFFYVASSSTNPETGRW----LMASLG--HLPRPNPSHK 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696	7/16 (44%)
		ChtBD2	1688..1734	CDD:214696
ZNF512B	XP_024307718.1	DNA_pol3_gamma3	<237..462	CDD:331207	52/269 (19%)
		C2H2 Zn finger	610..631	CDD:275368	1/20 (5%)
		C2H2 Zn finger	646..667	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3552
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940