Protein Alignment Muc68E and IMPG2

DIOPT Version :9

• Sequence 1: NP_996064.1
• Gene: Muc68E / 2768990
• FlyBaseID: FBgn0053265
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_057331.2
• Gene: IMPG2 / 50939
• HGNCID: 18362
• Length: 1241
• Species: Homo sapiens
• Alignment Length: 1209
• Identity: 224/1209 - (18%)
• Similarity: 399/1209 - (33%)
• Gaps: 351/1209 - (29%)

  Fly   809 VEDSTPIPEETTTVGQETTYDPEGSTT---REEDTTVAIETTTEKPEDDTTAEDSTPI------- 863
            :|...|.....|.:..|...:|:.:.:   .||.|.:::.|..::|.|....|....|
Human    20 IEGDFPSLTAQTYLSIEEIQEPKSAVSFLLPEESTDLSLATKKKQPLDRRETERQWLIRRRRSIL 84

  Fly   864 --------PEESTT-------------VAQETTYD----------------------PEGSTT-- 883
                    |:||..             |.||..::                      .:|.|:
Human    85 FPNGVKICPDESVAEAVANHVKYFKVRVCQEAVWEAFRTFWDRLPGREEYHYWMNLCEDGVTSIF 149

  Fly   884 --------REDDTTVAMETTTEKREDDTTVEDSTPIPEESTTVAQDTT-NDPEGSTTREEDTTVA 939
                    ..:..::.|:..|..:|..::.|.|:|:|...|:...||| :.|.......|.   |
Human   150 EMGTNFSESVEHRSLIMKKLTYAKETVSSSELSSPVPVGDTSTLGDTTLSVPHPEVDAYEG---A 211

  Fly   940 IETTTEKPEDDTTVEDSTPIPEETTTVGQ---ETTYDPEGSTTREDDTTVAIDTTTEKPEDDTTV 1001
            .|::.|:||:..:.|....|.|.|...|:   |.:....|...||:                  :
Human   212 SESSLERPEESISNEIENVIEEATKPAGEQIAEFSIHLLGKQYREE------------------L 258

  Fly  1002 EDSTP-----IPEESTTVAQDT-TNDP--------EGSTTREDDTTV-----------AIDTTT- 1040
            :||:.     :.||..:..::. |..|        |..:.:|:|:.|           ||..||
Human   259 QDSSSFHHQHLEEEFISEVENAFTGLPGYKEIRVLEFRSPKENDSGVDVYYAVTFNGEAISNTTW 323

  Fly  1041 -------EKPEDDTTVEDSTPIPEESTTIAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVE 1098
                   .|.|:...||    :.::.|.:...:.:....:.|.:.:..:...:....|:....:.
Human   324 DLISLHSNKVENHGLVE----LDDKPTVVYTISNFRDYIAETLQQNFLLGNSSLNPDPDSLQLIN 384

  Fly  1099 DSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVA---Q 1160
            ....:..::    :|...:.:.|:.:...:::.          |.|.:.:.|..:||.|.:   .
Human   385 VRGVLRHQT----EDLVWNTQSSSLQATPSSIL----------DNTFQAAWPSADESITSSIPPL 435

  Fly  1161 DTTNDPEGSTTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDPEGSTTREDDTT 1225
            |.::.|..:|.|        |..:|.|..|.........|.:   :|..::  ||         .
Human   436 DFSSGPPSATGR--------ELWSESPLGDLVSTHKLAFPSK---MGLSSS--PE---------V 478

  Fly  1226 VAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVE 1290
            :.:.:.|........::...|:..|..|         .||...||..     ...|:.||..:::
Human   479 LEVSSLTLHSVTPAVLQTGLPVASEERT---------SGSHLVEDGL-----ANVEESEDFLSID 529

  Fly  1291 D------STPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTT 1349
            .      :.|:|:|:....:|:......|..........:|:.|.|.:|...|....|    ..:
Human   530 SLPSSSFTQPVPKETIPSMEDSDVSLTSSPYLTSSIPFGLDSLTSKVKDQLKVSPFLP----DAS 590

  Fly  1350 IAQETTYD---PEGSTTREDDTTVA-IETTTEKP---------EDDTT-----VEDSTPIPEEST 1396
            :.:|..:|   ..||..:.|..|.. .||::||.         |||.:     :||...:..:.
Human   591 MEKELIFDGGLGSGSGQKVDLITWPWSETSSEKSAEPLSKPWLEDDDSLLPAEIEDKKLVLVDK- 654

  Fly  1397 TVAQDTTNDPEGSTTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDPEGSTTRE 1461
               .|:|:.....:..|.|     :.:|..||::.....:.||..:|.......|.....|....
Human   655 ---MDSTDQISKHSKYEHD-----DRSTHFPEEEPLSGPAVPIFADTAAESASLTLPKHISEVPG 711

  Fly  1462 DD-----------TTVAIETTTEKPEDDTTV--EDSTPIPEETTTVAQETTYDPEGSTTRDDT-- 1511
            .|           |:|||..:|:|.:....:  ||.    |:.|..:....:|.|.|..:.|.
Human   712 VDDYSVTKAPLILTSVAISASTDKSDQADAILREDM----EQITESSNYEWFDSEVSMVKPDMQT 772

  Fly  1512 --TVAIE--------TTTEKPEDDTTAEGSTP-------IPDTSTTVNQDTTTD---ESSTVVTT 1556
              |:..|        ::.||...|..|  |||       :..|.:|....||..   |...::..
Human   773 LWTILPESERVWTRTSSLEKLSRDILA--STPQSADRLWLSVTQSTKLPPTTISTLLEDEVIMGV 835

  Fly  1557 TNIPKESTTLGDSTLSP----GENSTAG---QVSTST----------------TLVYDTTSSPIP 1598
            .:|..|...:|.....|    .:|...|   ::|||.                .|.|..||..:.
Human   836 QDISLELDRIGTDYYQPEQVQEQNGKVGSYVEMSTSVHSTEMVSVAWPTEGGDDLSYTQTSGALV 900

  Fly  1599 --SSSRSTTLEPS----SSSSPETTTSS-------LPPLSCS-TGYQYL---------------- 1633
              .|.|.|.:..|    :.:|.|.....       :|.|..: ||:|.|
Human   901 VFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRM 965

  Fly  1634 ----PHPTNCHKYIH------CSNGHELIMECPANLYWDYHKFVCSGDSGVCYNDTENSNP-EEK 1687
                ..|.|.:..::      |:..:..:     ||..|  |:....:||      :.:|| :.:
Human   966 KFANSVPPNVNNAVYMILEDFCTTAYNTM-----NLAID--KYSLDVESG------DEANPCKFQ 1017

  Fly  1688 VCGPGVDFLAHPTDCTMYLQCSNGV--ALERKCPDPLYWNPEIKSCDWSNKYCTN------LRAS 1744
            .|....:.|.:|.......:|..|.  ..||.|.         ..||....:|.|      :...
Human  1018 ACNEFSECLVNPWSGEAKCRCFPGYLSVEERPCQ---------SLCDLQPDFCLNDGKCDIMPGH 1073

  Fly  1745 QSI-SCAAGMNFNVFQSDCSKYVKCFGLRGVVMSCNSGL 1782
            .:| .|..|.|:......|.::|....:.|:.::...||
Human  1074 GAICRCRVGENWWYRGKHCEEFVSEPVIIGITIASVVGL 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696	5/22 (23%)
		ChtBD2	1626..1668	CDD:214696	11/68 (16%)
		ChtBD2	1688..1734	CDD:214696	10/47 (21%)
IMPG2	NP_057331.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..223		15/45 (33%)
		SEA	240..349	CDD:295333	23/130 (18%)
		Hyaluronan-binding motif involved in chondroitin sulfate A-binding. /evidence=ECO:0000250	259..267		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..684		5/28 (18%)
		SEA	893..1015	CDD:214554	25/134 (19%)
		Hyaluronan-binding motif involved in chondroitin sulfate C-binding. /evidence=ECO:0000250	1080..1088		2/7 (29%)
		Hyaluronan-binding motif involved in chondroitin sulfate A-and C-binding. /evidence=ECO:0000250	1125..1133
		Hyaluronan-binding motif involved in chondroitin sulfate C-binding. /evidence=ECO:0000250	1136..1145
		Hyaluronan-binding motif involved in chondroitin sulfate A-and C-binding motif. /evidence=ECO:0000250	1210..1218

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000