Protein Alignment Muc68E and MUC1

DIOPT Version :10

• Sequence 1: NP_996064.1
• Gene: Muc68E / 2768990
• FlyBaseID: FBgn0053265
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_001358649.2
• Gene: MUC1 / 4582
• HGNCID: 7508
• Length: 1230
• Species: Homo sapiens
• Alignment Length: 1166
• Identity: 286/1166 - (24%)
• Similarity: 397/1166 - (34%)
• Gaps: 226/1166 - (19%)

  Fly   553 TVAIETTTEKPEDDTTAE---DSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKREDD 614
            ||...||..||....|..   .|||..|:.|:..|.:                ::.::|||....
Human    16 TVLTATTAPKPATVVTGSGHASSTPGGEKETSATQRS----------------SVPSSTEKNAVS 64

  Fly   615 TT---VEDSTPIPEESTTVAQDTTNDP-------EGSTTREDDTTV-----AIETTTEKPEDDTT 664
            .|   :...:|....|||..||.|..|       ..:|..:|.|:|     |:.:||....|.|:
Human    65 MTSSVLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTS 129

  Fly   665 AEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQE 729
            |.|:.|.|        .:|..|....|...||..|..:|..:....|:..|:.|.|        .
Human   130 APDNKPAP--------GSTAPPAHGVTSAPDTRPAPGSTAPQAHGVTSAPDTRPAP--------G 178

  Fly   730 TTYDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTV 794
            :|..|....|...||..|..:|.......|:|.|:.|.|..:...|...|:.|        ||..
Human   179 STAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPAAHGVTSAP--------DTRP 235

  Fly   795 AIETTTEKREDDTTVEDSTPIPEETTTVGQETTYDPEGSTTREEDTTVAIETTTEKPEDDTTAED 859
            |..:|..:....|:..|:.|.|..|.        .|....|...||..|..:|.......|:|.|
Human   236 APGSTAPQAHGVTSAPDTRPAPGSTA--------PPAHGVTSAPDTRPAPGSTAPPAHGVTSAPD 292

  Fly   860 STPIPEESTTVAQETTYDPEGSTTREDDTTVAMETTTEKREDDTTVEDSTPIPEESTTVAQDTTN 924
            :.|.|..:...|...|..||        :..|..:|.......|:..:|.|.|..:...|...|:
Human   293 TRPAPGSTAPPAHGVTSAPE--------SRPAPGSTAPAAHGVTSAPESRPAPGSTAPAAHGVTS 349

  Fly   925 DPE-----GST-------TREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDPE-- 975
            .||     |||       |...||..|..:|.......|:..|:.|.|..|.......|..|:
Human   350 APESRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTR 414

  Fly   976 ---GST-------TREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTRED 1030
               |||       |...||..|..:|.......|:..:|.|.|..:...|...|:.|| |.....
Human   415 PAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPESRPAPGSTAPPAHGVTSAPE-SRPAPG 478

  Fly  1031 DTTVAIDTTTEKPEDDTTVEDSTPIPEESTTIAQETTYDPE-----GST-------TREDDTTVA 1083
            .|..|....|..||       |.|.|..:...|...|..||     |||       |...||..|
Human   479 STAPAAHGVTSAPE-------SRPAPGSTAPAAHGVTSAPESRPAPGSTAPPAHGVTSAPDTRPA 536

  Fly  1084 IETTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDS 1148
            ..:|.......|:..|:.|.|..:...|...|:.|        ||..|..:|.......|:..|:
Human   537 PGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAP--------DTRPAPGSTAPPAHGVTSAPDT 593

  Fly  1149 TPIPEESTTVAQDTTNDPEGSTTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYD 1213
            .|.|..:...|...|:.|        ||..|..:|.......|:..|:.|.|..|.        .
Human   594 RPAPGSTAPPAHGVTSAP--------DTRPAPGSTAPPAHGVTSAPDTRPAPGSTA--------P 642

  Fly  1214 PEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPE-----GST------- 1266
            |....|...||..|..:|.......|:..:|.|.|..:...|...|:.||     |||
Human   643 PAHGVTSAPDTRPAPGSTAPAAHGVTSAPESRPAPGSTAPAAHGVTSAPESRPAPGSTAPPAHGV 707

  Fly  1267 TREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKP 1331
            |...||..|..:|.......|:..|:.|.|..:...|...|:.|        ||..|..:|....
Human   708 TSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAP--------DTRPAPGSTAPPA 764

  Fly  1332 EDDTTVEDSTPIPEESTTIAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEEST 1396
            ...|:..|:.|.|        .:|..|....|...||..|..:|.......|:..|:.|.|..:.
Human   765 HGVTSAPDTRPAP--------GSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTA 821

  Fly  1397 TVAQDTTNDPEGSTTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDPEGSTTRE 1461
            ..|...|:.|        ||..|..:|.......|:..|:.|.|..|.......|..|:  |.|.
Human   822 PPAHGVTSAP--------DTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPD--TRRA 876

  Fly  1462 DDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVAQETTYDPEGSTTRDDTTVAIETTTEKPEDDT 1526
            ..:|.|..:|.......|:..|:.|.|..|...|...|..|                     |:.
Human   877 PGSTPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAP---------------------DNR 920

  Fly  1527 TAEGSTPIPDTSTTVNQDTTTDESSTVVTTTNIPKESTTLGDSTLSPGENSTAGQV-----STST 1586
            .|.|||..|..:.|....:.:..:||:|       .:.|...:|.:|...||...:     .|.|
Human   921 PALGSTAPPVHNVTSASGSASGSASTLV-------HNGTSARATTTPASKSTPFSIPSHHSDTPT 978

  Fly  1587 TLVYDTTSSPIPSSSRSTTLEPSSSSSPETTTSSLPPLSCSTGYQYLPHPTNCHKYIHCSN 1647
            ||...:|.:. .||:..:|:.|.:||:..|:    |.||....:.:|.        .|.||
Human   979 TLASHSTKTD-ASSTHHSTVPPLTSSNHSTS----PQLSTGVSFFFLS--------FHISN 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	rne	<158..303	CDD:236766
		MDN1	300..1293	CDD:444083	201/805 (25%)
		rne	<1358..1503	CDD:236766	36/144 (25%)
		ChtBD2	1626..1668	CDD:214696	4/22 (18%)
		ChtBD2	1688..1734	CDD:214696
		ChtBD2	<1761..1791	CDD:214696
MUC1	NP_001358649.2	PRK07003	<92..437	CDD:235906	94/384 (24%)
		PHA03247	<276..826	CDD:223021	149/605 (25%)
		PRK12323	<758..982	CDD:481241	62/269 (23%)
		SEA	1009..1127	CDD:214554	7/26 (27%)