DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc68E and IMPG1

DIOPT Version :9

Sequence 1:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001554.2	Gene:	IMPG1 / 3617	HGNCID:	6055	Length:	797	Species:	Homo sapiens

Alignment Length:	466	Identity:	87/466 - (18%)
Similarity:	154/466 - (33%)	Gaps:	113/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 REDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEES 675
            |:|:.:.|.:...|.|:..::.|..|...|......|.|:..|..      |.|..| |.:|
Human   166 RKDEISAEKTLGEPGETIVISTDVANVSLGPFPLTPDDTLLNEIL------DNTLND-TKMP--- 220

  Fly   676 TTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQ------------ 728
             |..:||    |.:...|....:::....:|.:.: ..:..:|..:|....:|
Human   221 -TTERET----EFAVLEEQRVELSVSLVNQKFKAE-LADSQSPYYQELAGKSQLQMQKIFKKLPG 279

  Fly   729 ---------ETTYDPEGSTTREDDTTVAIE---TTTEKPEDDTTAEDSTPIPEEST---TVAQDT 778
                     ....:.:||::.|...|...:   ...:.|..|..:.||..|..|..   |:.:|
Human   280 FKKIHVLGFRPKKEKDGSSSTEMQLTAIFKRHSAEAKSPASDLLSFDSNKIESEEVYHGTMEED- 343

  Fly   779 TNDPEGSTTREDDTTVAIETTTEKREDDT-TVEDSTPIPEETTTVGQETTYD-PEGSTTREEDTT 841
             ..||...|..|...:..:...|::..|. |::.:..|.......|.:|..: |.......||.|
Human   344 -KQPEIYLTATDLKRLISKALEEEQSLDVGTIQFTDEIAGSLPAFGPDTQSELPTSFAVITEDAT 407

  Fly   842 VAIETTTEKPEDDTT--AEDSTPIPEESTTVAQETTYDPE--GSTTREDDTTVAMETT----TEK 898
            ::.|....:|:.:|.  ||...|          :|::.|.  .||:..:.....|.::    |::
Human   408 LSPELPPVEPQLETVDGAEHGLP----------DTSWSPPAMASTSLSEAPPFFMASSIFSLTDQ 462

  Fly   899 REDDTTVEDSTPIPEESTTVAQD---------------TTNDPEGSTTREEDTTVAIETTTEKPE 948
            ...||...|.|.:....|....|               .::|...|:...||..        :..
Human   463 GTTDTMATDQTMLVPGLTIPTSDYSAISQLALGISHPPASSDDSRSSAGGEDMV--------RHL 519

  Fly   949 DDTTVEDSTPIPEETTTVGQETTYDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTT 1013
            |:..:.| ||.|.|...:.:..:.                        .|..:||:||:......
Human   520 DEMDLSD-TPAPSEVPELSEYVSV------------------------PDHFLEDTTPVSALQYI 559

  Fly  1014 VAQDTTNDPEG 1024
            .....|..|:|
Human   560 TTSSMTIAPKG 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696
		ChtBD2	1688..1734	CDD:214696
IMPG1	NP_001554.2	SEA	234..>290	CDD:279699	4/56 (7%)
		SEA	574..660	CDD:279699
		Heparin-and hyaluronan-binding. /evidence=ECO:0000250\|UniProtKB:Q8JIR8	621..629
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000