DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc68E and Zfp512

DIOPT Version :9

Sequence 1:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_766581.2	Gene:	Zfp512 / 269639	MGIID:	1917345	Length:	562	Species:	Mus musculus

Alignment Length:	484	Identity:	90/484 - (18%)
Similarity:	155/484 - (32%)	Gaps:	144/484 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1388 STPIPEESTTVAQDTTNDPEGSTTREEDTTV---AIETTTEKPEDDTTVEDST-----PIPEETT 1444
            :||.|   |::.|..:....|:.......::   :.:.|.  |.:|:....|:     |:.:.|.
Mouse    10 ATPGP---TSLKQQRSTRIVGAKNNRAQCSIKDNSFQYTI--PHEDSLSGSSSASSCEPVSDFTA 69

  Fly  1445 TVGQET------------TYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVAQE 1497
            |:.:.|            |...||:..:|.:.  |......|.|:|   ||...:|::     :.
Mouse    70 TLRKSTYWMKMRRIKPAATSQVEGAGEKEKER--AKGKRNVKQEED---EDYRELPQK-----KH 124

  Fly  1498 TTY------------DPEGSTTRDDTTV-AIETTTEKPEDDTTAEGSTPIPDTSTTVNQDTTTDE 1549
            ..|            .|:....|.:..| |..:..||...:...:||...| |...|.:.|....
Mouse   125 KLYGRKQRPKAQPHPKPQARRVRKEPPVYAAGSMEEKWYLEIMDKGSVSCP-TCQAVGRKTIEGL 188

  Fly  1550 SSTVVTTTNIPKESTTLGDSTLSPGENSTAGQVSTSTTLVY----DTTSSPIPSSSRSTTLEPSS 1610
            ...:   .|..:|..|.         :....|:.:...:.|    :..|.||..:..... |||.
Mouse   189 KKHM---ENCKQEMFTC---------HHCGKQLHSLAGMKYHVMANHNSLPILKAGDEVD-EPSE 240

  Fly  1611 SSSPETTTSSLPPL-----SCSTGYQ----YLPHPTNCHKYIHCSNGHELIMECPANLYWDYHKF 1666
            .....|....:..|     |||:.:.    ||.|...|.|  ..|...:|.::|       :|
Mouse   241 RERLRTVLKRMGKLRCMRESCSSTFTSIMGYLYHVRKCGK--EASELEKLALKC-------HH-- 294

  Fly  1667 VCS----GDSGVCYNDTENSNPEEKVCGPGVDFLAHPTDC--TMYLQCSNGVALERKCPD-PLYW 1724
             |.    ..:|:.|:......|   |..|.    :...||  .|.|:...|..::|:... .:|.
Mouse   295 -CGKPYRSKAGLAYHMRSEHGP---VFFPE----SEQPDCLKEMSLEAKGGGRVQRRSAKIAVYH 351

  Fly  1725 NPEIKSC----DWS------------------------------NKYCTNLRASQSISCAAGMNF 1755
            ..|:.|.    :|.                              :|:.|:::....|.|.
Mouse   352 LQELASAELTKEWPKRKVLQDLVPDDRKLKYTRPGLPTFSQEVLHKWKTDIKKYHRIQCP----- 411

  Fly  1756 NVFQSDC-SKYVKCFGLRGVVMSCNSGLY 1783
               ...| :.|....||:..:.||..|.:
Mouse   412 ---NQGCEAVYSSVSGLKAHLGSCTLGTF 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696	7/24 (29%)
		ChtBD2	1626..1668	CDD:214696	11/45 (24%)
		ChtBD2	1688..1734	CDD:214696	11/52 (21%)
Zfp512	NP_766581.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..150		14/73 (19%)
		AdoMet_MTases	<269..355	CDD:302624	22/104 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3552
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030