DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc68E and Cd44

DIOPT Version :9

Sequence 1:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_037056.3	Gene:	Cd44 / 25406	RGDID:	2307	Length:	779	Species:	Rattus norvegicus

Alignment Length:	878	Identity:	198/878 - (22%)
Similarity:	300/878 - (34%)	Gaps:	236/878 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 QLNLNKNNDTASKLKIGAPYYYQIKITSPTKI-----KSLPVEVENDRKDSSGIDTT----VEDL 140
            |::||.....|....:.....|.|..|....:     .:||...:.:...|.|.:|.    :|..
  Rat    24 QIDLNITCRYAGVFHVEKNGRYSISRTEAADLCEAFNTTLPTMAQMELALSKGFETCRYGFIEGH 88

  Fly   141 TPIPE---ETTTVAQET-TYDPEGSTTREDDTTVAIETTTEKPEDDTTVED---STPIPEESTTV 198
            ..||.   .....|..| .|....|.|...| |.....:....||.|:|.|   |...|...|.|
  Rat    89 VVIPRIHPNAICAANNTGVYILLASNTSHYD-TYCFNASAPLEEDCTSVTDLPNSFDGPVTITIV 152

  Fly   199 AQE-TTYDPEGS--TTRED-DTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQETTYDPEGSTT 259
            .:: |.|..:|.  |.:|| |.:..|:   |.....:|:|.||  ||.........|..|.|.
  Rat   153 NRDGTRYSKKGEYRTHQEDIDASNIID---EDVSSGSTIEKST--PEGYILHTDLPTSQPTGD-- 210

  Fly   260 RDD-----ETTVAIETTTEKPEDDTTVEDSTPI-----PEESTTVAQETTYDPEGSTTREDDTTV 314
            |||     .|...|.:|.......|..:.:..|     ..:|||..||.|      ||    .|.
  Rat   211 RDDAFFIGSTLATIASTVYSKSHATAQKQNNWIWSWFGNSQSTTQTQEPT------TT----ATT 265

  Fly   315 AIETTTEKPEDDTTVEDSTPIPEESTTVAQ---ETTYDPEGSTTREDDTTVAIETTTEKPEDDTT 376
            |:.||.|.|          |..:|    ||   ...:.|..|.:.       :.|||:.|..::.
  Rat   266 ALMTTPETP----------PKRQE----AQNWFSWFFQPSESKSH-------LHTTTKMPGTESN 309

  Fly   377 VEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQE 441
            ...:...|.|..  ..||...|..|.:..||....|.:|..          :||.....|...||
  Rat   310 TNPTGWKPNEEN--EDETDKYPNFSGSGIDDDEDFISSTIA----------TTPWVSAHTKQNQE 362

  Fly   442 TTY------DPE---GSTTREDD-----TTVAIETTTEKPE---DDTTVEDSTPIPEESTTVAQE 489
            .|.      :||   .:|||..|     |:...|..|::|:   ::...:|     ||.|..|..
  Rat   363 RTQWNPIHSNPEVLLQTTTRMTDIDRNSTSAHGENWTQEPQPPFNNHEYQD-----EEETPHATS 422

  Fly   490 TTYDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTV 554
            ||:....|||.|      ..|..||..::.....:.|.|.|.:.|.       ||:|....:...
  Rat   423 TTWAAPNSTTEE------AATQKEKWFENEWQGKNPPTPSEDSHVT-------EGTTASGHNNHP 474

  Fly   555 AIETTTEKPEDDTTAEDSTPIPEESTTVAQETTYDP------EGSTTREDDTTVAIETTTEKRED 613
            :...||:..||                |:....:||      :|..|...||..:..||.:
  Rat   475 SQRMTTQSQED----------------VSWTDFFDPISHPMGQGHQTESKDTDSSHSTTLQ---- 519

  Fly   614 DTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTV 678
             .|...:|.:.|:.......:...|:..:  ::.:|:..|  .|:.||..|   ::.:|..:.:.
  Rat   520 -PTAAPNTHLVEDLNRTGPLSVTTPQSHS--QNFSTLPGE--LEEGEDHPT---TSVLPSSTKSG 576

  Fly   679 AQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIP----------EESTTVAQETTYD 733
            |:.     .||..|  |||.::|..|  |:...|:|:.|..|          |...|||.::.::
  Rat   577 ARR-----GGSLPR--DTTTSLEGYT--PQYPDTMENGTLFPVTPAKTEVFGETEGTVATDSNFN 632

  Fly   734 PEGSTTREDDTTV----AIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDPEGSTTREDDT-- 792
            .:||...:.|:::    ..:|.|...|                .....:.|...|.||.....
  Rat   633 VDGSLPGDGDSSMDPRGGFDTVTHGSE----------------LAGHSSGNQDSGVTTTSGPARR 681

  Fly   793 --------------------TVAIETTTEKR----------EDDTTVEDSTPIPEETTTVGQETT 827
                                .|.|...:.:|          ..:.||||..|           :.
  Rat   682 PQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGTVEDRKP-----------SE 735

  Fly   828 YDPEGSTTREEDTTVAIETTTEKPEDDTTAEDS 860
            .:.|.|.::|....|..| .||.|:...||:::
  Rat   736 LNGEASKSQEMVHLVNKE-PTETPDQFMTADET 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696
		ChtBD2	1688..1734	CDD:214696
Cd44	NP_037056.3	Link_domain_CD44_like	29..172	CDD:239593	33/143 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000