Protein Alignment Muc68E and srap-1

DIOPT Version :9

• Sequence 1: NP_996064.1
• Gene: Muc68E / 2768990
• FlyBaseID: FBgn0053265
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_001364584.1
• Gene: srap-1 / 174709
• WormBaseID: WBGene00011522
• Length: 3532
• Species: Caenorhabditis elegans
• Alignment Length: 2113
• Identity: 585/2113 - (27%)
• Similarity: 830/2113 - (39%)
• Gaps: 606/2113 - (28%)

  Fly    15 VQLESKAVEMKNKKWNFR-EFIICVAVTVVLTKIVH----VKTQHQQSLQKLSNQY--------- 65
            |..:|:.:|.:||::... |..:.|....:.....:    ...::..|.|:.|..|
 Worm   743 VHFQSQPIEERNKEFTAPFELNLKVPTAEICAHRCYQDGCTAAKYDPSTQQCSLAYEDKPFCGNG 807

  Fly    66 ----VIRDGDTQYI-------------KSRTSEKVSQLNLNKNN-----DTAS-KLKIGAPYYYQ 107
                :.|...|.:|             ...|..:|::.||...:     |||| :.....|
 Worm   808 RLVNIDRSDKTVWIHCLSCVPLKNSKPAENTDGEVTESNLPDGSGEHGADTASGEEPTSTP---- 868

  Fly   108 IKITSPTKIKSLPVEVENDRK--DSSGIDTTVEDLTPI-PEETTTVA------QETTYDPEGSTT 163
              ||:||       :..||.:  ::||.:||....|.. .|||||.|      :|||......::
 Worm   869 --ITAPT-------DFSNDDQVTEASGEETTTAAATEASSEETTTSAVTEGSGEETTVPTTVESS 924

  Fly   164 REDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVA------QETTYDPEGSTTREDDTTVAI-E 221
            .|:....:....||..:||...|.|   .||:||.|      :|||.......:.|:.||.|: |
 Worm   925 GEEPALSSTSVPTELSKDDQVTEAS---GEETTTAAATEASSEETTTPAVTEASGEESTTSAVTE 986

  Fly   222 TTTEKPEDDTTVE--------DSTPIP--------------EESTTVA------QETTYDPEGST 258
            .:.|:....||||        .||.:|              ||:||.|      :|||.......
 Worm   987 GSGEEITVPTTVESSGEEPALSSTSVPTELSKDDQVTEASGEETTTAAATEASSEETTTPAVTEA 1051

  Fly   259 TRDDETTVAI-ETTTEKPEDDTTVE--------DSTPIPE-------------ESTTVAQETTYD 301
            :.::.||.|: |.:.|:....||||        .||.||.             |.||.|..|...
 Worm  1052 SGEESTTSAVTEGSGEEITVHTTVESSGEEPAISSTSIPTELSKDDQVTEASGEETTTAAATEAS 1116

  Fly   302 PEGSTT-------REDDTTVAIETTTEKPEDDTTV------------EDSTPIP----------- 336
            .|.:||       .|:.||.|:   ||:..::|||            ..||.||
 Worm  1117 LEATTTPAVTEASGEEITTSAV---TEESGEETTVVAVVESSGEEQASSSTSIPTELSKDDQVTE 1178

  Fly   337 ---EESTTVA-----QETTYDPEGSTTREDDTTV--AIETTTEKPEDDTTVEDSTPIP------- 384
               ||:||.|     .|.|..|..:....::|||  .:|::.|:|     ...||.||
 Worm  1179 ASGEETTTAAATEASSEATTTPAVTEASGEETTVVAVVESSGEEP-----ASSSTSIPTELSKDN 1238

  Fly   385 -------EESTTVA------QETTYDPEGSTTREDDTTVAIETTTEKPEDDTTV----------- 425
                   ||:.|.|      :|||......|:.|:.|   |...||...::|||
 Worm  1239 QVTEASGEETNTAAVTEGSGEETTTAAATETSSEETT---ISAVTEASGEETTVVAVVQSSGEEP 1300

  Fly   426 -EDSTPIPEESTTVAQETTYDPEGSTT-------REDDTTVAIETTTEKPEDDTT----VEDSTP 478
             ..||.||.|.:...|.|....|.:||       .|:.||:|:   ||...::||    ||.|..
 Worm  1301 ASSSTSIPTELSKDDQVTEASGEETTTAAATEASSEETTTLAV---TEGSGEETTVVAVVESSGE 1362

  Fly   479 IP-EESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDP 542
            .| ..||::..|.:.|.:.:....::||.|  ..||...::|....:|....|:||....|....
 Worm  1363 EPASSSTSIPTELSKDDQVTEASGEETTTA--AVTEGSGEETVTPAATEASSEATTTPAGTEASG 1425

  Fly   543 EGSTTR-------EDDTTVA-IETTTEKPEDDTTAEDSTPIP--------------EESTTVAQE 585
            |.:||.       |::|.|| :|::.|:|     |..||.||              ||:||.|..
 Worm  1426 EETTTSAVTEGSGEENTVVAVVESSGEEP-----ASSSTSIPTELSNDDQVTEGSGEETTTAAAT 1485

  Fly   586 TTYDPEGST------TREDDTTVAI------ETTTE-----KREDDTTV-----------EDSTP 622
            .|...|.:|      :.|:.||.|:      ||||.     ..|::|.|           ..||.
 Worm  1486 ETSSEETTTSVVTEGSGEETTTSAVTEASGEETTTSAVTEGSGEENTVVAVVQSSGEEPASSSTS 1550

  Fly   623 IPEESTTVAQDTTNDPEGSTT-------REDDTTVAI------ETTT----EKPEDDTTAEDSTP 670
            ||.|.:...|.|....|.:||       .|:.||.|:      ||||    |...|:||...:|.
 Worm  1551 IPTELSKDDQVTEASGEETTTAAATEASSEETTTSAVTEGSGEETTTSAVSEGSGDETTTAAATE 1615

  Fly   671 IPEESTTVAQETTYDPEGSTT--------REDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVA 727
            ...|.|..:..|....|.:||        .|..|..|.|.::|:.......|.|   .||:||.|
 Worm  1616 ASSEETITSAVTEGSGEETTTSAVTEGSGEETTTAAATEASSEETITSAVTEGS---GEETTTSA 1677

  Fly   728 ------QETTYDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDPEGST 786
                  :|.|......::.|:....::...||..:||...|.|   .||:||.|...|:..|.:|
 Worm  1678 VTEGSGEEITVPTTVESSGEEPALSSMSIPTELSKDDQVTEAS---GEETTTAAATETSSEETTT 1739

  Fly   787 ------TREDDTTVAI-------------ETTTEKREDDTTVEDSTPIPEETTTV------GQET 826
                  :.|..|.||:             ...||..:||...|.|   .|||||.      .:||
 Worm  1740 SVVTEGSGEQTTVVAVVESSGEEPASSSTSIPTELSKDDQVTEAS---GEETTTAAATEASSEET 1801

  Fly   827 TYDPEGSTTREEDTTVA-IETTTEKPEDDTTAEDSTPIPEESTTVAQETTYDPEGSTTREDDTTV 890
            ........:.||.|.|| :|::.|:|     |..||.:|.|.:...|.|....|.:||.......
 Worm  1802 ITSAVTEGSGEETTVVAVVESSGEEP-----ASSSTSVPTELSKDDQVTEASGEETTTAAATEAS 1861

  Fly   891 AMETT----TEKREDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTR-------EEDTTVA-IETT 943
            :.|||    ||...::||....|....|:||....|....|.:||.       ||.|.|| :|::
 Worm  1862 SEETTTSAVTEGSGEETTTSAVTEASSEATTTPAGTEASGEETTTSAVTEGSGEETTVVAVVESS 1926

  Fly   944 TEKPEDDTTVEDSTPIPEE-------TTTVGQET-----TYDPEGSTTR-------EDDTTVAI- 988
            .|:|     ...||.||.|       |...|:||     |...|.:||.       ||.|.||:
 Worm  1927 GEEP-----ASSSTSIPTELSKNDQVTEASGEETITAAATEASEETTTSAVTEGSGEDTTVVAVV 1986

  Fly   989 ---------------------DTTTEKPEDDTTVEDSTPIPEESTTVA------QDTT------- 1019
                                 |..||...::||...:|...||:||.|      ::||
 Worm  1987 ELSGEQPASSSTSIPTELSKDDQVTEASGEETTTAAATEASEETTTSAVTEGSGEETTVVAVVES 2051

  Fly  1020 --NDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTIAQETTYDPEGSTTREDDTTV 1082
              .:|..|:|.........|..||...::||...:|...||:||.|.     .|||  .||.|.|
 Worm  2052 SGEEPASSSTSIPTELSKDDQVTEASGEETTTAAATEASEETTTSAV-----TEGS--GEDTTVV 2109

  Fly  1083 A-IETTTEKP------------EDDTTVEDSTPIPEESTTVA-----QDTTNDPEGSTTREDDTT 1129
            | :|::.|:|            :||...|.|   .||:||.|     ::||.......:.||.|.
 Worm  2110 AVVESSGEQPASSSTSIPTELSKDDQVTEAS---GEETTTAAATEASEETTTSAVTEGSGEDTTV 2171

  Fly  1130 VAI----------------------DTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTR 1172
            ||:                      |..||...::||...:|...||:||.|.     .|||  .
 Worm  2172 VAVVESSGEQPASSSTSIPTELSKDDQVTEASGEETTTAAATEASEETTTSAV-----TEGS--G 2229

  Fly  1173 EEDTTVA-IETTTEKPEDDTTVEDSTPIPEE-------TTTVGQETTYDPEGSTTREDDTTVAID 1229
            ||.|.|| :|::.|:|     ...||.||.|       |...|:|||.......:.|:.||.|:
 Worm  2230 EETTVVAVVESSGEEP-----ASSSTSIPTELSKDDKVTEASGEETTTAAATDASSEETTTSAV- 2288

  Fly  1230 TTTEKPEDDTT----VEDSTPIP-EESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTV 1289
              ||...::||    ||.|...| ..||::..:.:.|.:.:....::||.|  ..||..|:.||.
 Worm  2289 --TEGSGEETTVVAVVESSDEEPASSSTSIPTELSKDDQVTEASGEETTTA--AATEASEETTTS 2349

  Fly  1290 EDSTPIPEESTTVA--QDTTNDPEGSTTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTIAQ 1352
            ..:....||:|.||  :.:..:|..|:|.........|..||...::||...:|....|.||.:.
 Worm  2350 AVTEGSGEETTVVAVVESSGEEPASSSTSIPTELSKDDKVTEASGEETTTAAATDASSEETTTSA 2414

  Fly  1353 ETTYDPEGSTTREDDTTVA-IETTTEKP------------EDDTTVEDSTPIPEESTTVA----- 1399
            .|    |||  .|:.|.|| :|::.|:|            :||...|.|   .||:||.|
 Worm  2415 VT----EGS--GEETTVVAVVESSDEEPASSSTSIPTELSKDDQVTEAS---GEETTTAAATEAS 2470

  Fly  1400 QDTTNDPEGSTTREEDTTVA-IETTTEKP------------EDDTTVEDSTPIPEETTT-----V 1446
            ::||.......:.||.|.|| :|::.|:|            :||...|.|   .|||||     .
 Worm  2471 EETTTSAVTEGSGEETTVVAVVESSGEEPASSSTSIPTELSKDDQVTEAS---GEETTTAAATEA 2532

  Fly  1447 GQETTYDPEGSTTREDDTTVA-IETTTEKP------------EDDTTVEDSTPIPEETTTVA--- 1495
            .:|||.......:.||.|.|| :|::.|:|            :||...|.|   .|||||.|
 Worm  2533 SEETTTSAVTEGSGEDTTVVAVVESSGEQPASSSTSIPTELSKDDQVTEAS---GEETTTAAATE 2594

  Fly  1496 --QETTYDPEGSTTRDDTTV--AIETTTEKPEDDTTAEGSTPIPDTSTTVNQDTTTDESS----T 1552
              :|||.......:.::|||  .:|::.|:|     |..||.||   |.:::|....|:|    |
 Worm  2595 ASEETTTSAVTEGSGEETTVVAVVESSGEEP-----ASSSTSIP---TELSKDDQVTEASGEETT 2651

  Fly  1553 VVTTTNIPKESTTLGDSTLSPGENSTAGQVSTSTTLVYDTTSSPIPSSSRSTT----------LE 1607
            ....|....|.||....|...||.:|...|:..:.  .:||:|.:|....|||          :|
 Worm  2652 TAAATEASSEETTTSAVTEGSGEETTTSAVTEGSG--EETTTSAVPEGENSTTEAPAFVTGSEIE 2714

  Fly  1608 -PSSSSSPETTT--SSLPPLSCSTGYQYLPHPT 1637
             |||..|..|||  .|:|.::        |.|:
 Worm  2715 IPSSEESSSTTTHDPSIPVIT--------PKPS 2739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696	2/12 (17%)
		ChtBD2	1688..1734	CDD:214696
srap-1	NP_001364584.1	PRK13108	<1876..2013	CDD:237284	38/141 (27%)
		PAN_APPLE	<3374..3413	CDD:412169

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000