DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Muc68E and VCAN

DIOPT Version :9

Sequence 1:NP_996064.1 Gene:Muc68E / 2768990 FlyBaseID:FBgn0053265 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_004376.2 Gene:VCAN / 1462 HGNCID:2464 Length:3396 Species:Homo sapiens


Alignment Length:2610 Identity:542/2610 - (20%)
Similarity:820/2610 - (31%) Gaps:1005/2610 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 ISTNAS--VQLESKAVEMKNKKWNFREFIICVAVTVVLTKIVHVKTQHQQSLQKLSNQYVIRDGD 71
            :||:.|  :.:...:||| .|.::|         ..::||:....|:    ::.:...:....|.
Human   726 LSTSLSEPIHVTESSVEM-TKSFDF---------PTLITKLSAEPTE----VRDMEEDFTATPGT 776

  Fly    72 TQYIKSRT------------SEKVSQLNLNKNNDTASKLKIGAPYYYQIKITSPTKIKSLP---- 120
            |:|.::.|            :..||:.:.:::|.|:..|          :.|.|:....||    
Human   777 TKYDENITTVLLAHGTLSVEAATVSKWSWDEDNTTSKPL----------ESTEPSASSKLPPALL 831

  Fly   121 --VEVENDRKD-SSGIDTTVEDLTPIPEETTTVAQETT-------------YDPEGSTTREDDTT 169
              |.:....|| .|..:...::.|.||:.|....:|.|             :.|..||...:.:|
Human   832 TTVGMNGKDKDIPSFTEDGADEFTLIPDSTQKQLEEVTDEDIAAHGKFTIRFQPTTSTGIAEKST 896

  Fly   170 VAIETTTEKPEDDTTVEDSTPIPEESTTVAQETTYD--------PEGSTTREDDTTVAIE-TTTE 225
            :...||.||....|:.|.......|.:.:.:....|        |:.:.|.|.:....:. ::|:
Human   897 LRDSTTEEKVPPITSTEGQVYATMEGSALGEVEDVDLSKPVSTVPQFAHTSEVEGLAFVSYSSTQ 961

  Fly   226 KPEDDTTVEDST------------------PIPEESTTVAQ-------------ETTYDPEGSTT 259
            :|   ||..||:                  .:|.|...:.:             |.|..||  |.
Human   962 EP---TTYVDSSHTIPLSVIPKTDWGVLVPSVPSEDEVLGEPSQDILVIDQTRLEATISPE--TM 1021

  Fly   260 RDDETTVAIETTTEK--PEDDTTVEDSTP-------IPEESTTVAQETTYDPEGSTTREDDTTV- 314
            |   ||...|.||::  |..:.|.|...|       .|:|:.|...|...|....|..||:... 
Human  1022 R---TTKITEGTTQEEFPWKEQTAEKPVPALSSTAWTPKEAVTPLDEQEGDGSAYTVSEDELLTG 1083

  Fly   315 -----AIETT----------------TEKPEDDTTVEDSTPI--PEESTTVAQETTYDPEGSTT- 355
                 .:|||                ||.......|...||.  |:.|.:...|..|:.|||:| 
Human  1084 SERVPVLETTPVGKIDHSVSYPPGAVTEHKVKTDEVVTLTPRIGPKVSLSPGPEQKYETEGSSTT 1148

  Fly   356 ---------REDDTTVAIETTT---------------EKPEDDTTVEDST---PIPEESTTVAQE 393
                     ....|.:..||||               |||:....:|.||   .:|.:.||....
Human  1149 GFTSSLSPFSTHITQLMEETTTEKTSLEDIDLGSGLFEKPKATELIEFSTIKVTVPSDITTAFSS 1213

  Fly   394 -------TTYDPEGSTTRE-------------DDTTVAIETTTEKPEDDTTVEDSTPIPEESTTV 438
                   :.:.|..:.|::             .|..:..|:|:..|  .||:||         .|
Human  1214 VDRLHTTSAFKPSSAITKKPPLIDREPGEETTSDMVIIGESTSHVP--PTTLED---------IV 1267

  Fly   439 AQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVED---------STPIPEESTTVAQETTYDP 494
            |:||..|.:    ||..||.:...|  :|....||||         |||.|..|      |.:.|
Human  1268 AKETETDID----REYFTTSSPPAT--QPTRPPTVEDKEAFGPQALSTPQPPAS------TKFHP 1320

  Fly   495 ----------EGSTTREDD-TTVAIETTTEKPEDDTTAEDSTPI--------------------- 527
                      |..|.|..| :.:.....:|..||:..:|::.|:                     
Human  1321 DINVYIIEVRENKTGRMSDLSVIGHPIDSESKEDEPCSEETDPVHDLMAEILPEFPDIIEIDLYH 1385

  Fly   528 ------PEESTTVAQDTT------------------NDPEGSTTR--EDDTTVAIETTTEKPEDD 566
                  .||....|.|.|                  .|||.:..|  :.::....:..::..|.|
Human  1386 SEENEEEEEECANATDVTTTPSVQYINGKHLVTTVPKDPEAAEARRGQFESVAPSQNFSDSSESD 1450

  Fly   567 T------TAEDSTPI-PEES--TTVAQETTYDPE--GSTTR-----EDDTTVAI------ETTTE 609
            |      ..|.||.: |.||  ||.:.|.|:.||  ..|:.     |.|....:      |:.|.
Human  1451 THPFVIAKTELSTAVQPNESTETTESLEVTWKPETYPETSEHFSGGEPDVFPTVPFHEEFESGTA 1515

  Fly   610 KR------EDDTTV-----EDSTPI---PEEST-TVAQDTTNDPEGSTTREDDTTVAIETTTE-- 657
            |:      |.||.|     |.:.|:   ||||: .:|.|           ::...:|....||  
Human  1516 KKGAESVTERDTEVGHQAHEHTEPVSLFPEESSGEIAID-----------QESQKIAFARATEVT 1569

  Fly   658 --KPEDDTTAEDSTP--IP---------EESTTVAQETTYD------------------------ 685
              :..:.:|:...||  :|         ||:.|:......|                        
Human  1570 FGEEVEKSTSVTYTPTIVPSSASAYVSEEEAVTLIGNPWPDDLLSTKESWVEATPRQVVELSGSS 1634

  Fly   686 ----PEGSTTREDDTTVAIETTTEKPEDDTT----VEDSTPIPEESTTVAQETTYDP--EGSTTR 740
                .|||...|:|........|:..:.:||    ..|::.|..||......||..|  |..:.:
Human  1635 SIPITEGSGEAEEDEDTMFTMVTDLSQRNTTDTLITLDTSRIITESFFEVPATTIYPVSEQPSAK 1699

  Fly   741 EDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDT------------------TNDPEGSTT 787
            ...|....||.|.:....||.|:.....||.||....|                  ...|..:|:
Human  1700 VVPTKFVSETDTSEWISSTTVEEKKRKEEEGTTGTASTFEVYSSTQRSDQLILPFELESPNVATS 1764

  Fly   788 REDDTTVAIETTTEKREDDTTVEDSTPIPEETTT---VGQETT-----YDP---EGSTT------ 835
            .:..|..:..:.|...:.:..:.||||:..||.|   :|.:||     :.|   ||.||      
Human  1765 SDSGTRKSFMSLTTPTQSEREMTDSTPVFTETNTLENLGAQTTEHSSIHQPGVQEGLTTLPRSPA 1829

  Fly   836 -------------REEDTTVA-----------------------IETT-TEKPE--------DDT 855
                         ..|.|||:                       :||| :.:|.        |..
Human  1830 SVFMEQGSGEAAADPETTTVSSFSLNVEYAIQAEKEVAGTLSPHVETTFSTEPTGLVLSTVMDRV 1894

  Fly   856 TAEDSTPIPEESTTVAQ--ETTYDPE------GSTTRED-----------------DTTVAMETT 895
            .||:.|....|.....:  |..|..|      |....||                 :.||.||.:
Human  1895 VAENITQTSREIVISERLGEPNYGAEIRGFSTGFPLEEDFSGDFREYSTVSHPIAKEETVMMEGS 1959

  Fly   896 TEKREDDTTVEDSTPIP-------------EESTTVA------QDTTNDPEGS------------ 929
            .:....||....|| :|             ..||.|:      ::.|:..|||            
Human  1960 GDAAFRDTQTSPST-VPTSVHISHISDSEGPSSTMVSTSAFPWEEFTSSAEGSGEQLVTVSSSVV 2023

  Fly   930 --------------------------TTREED------TTVAIETT---TEKPEDDTTVEDSTPI 959
                                      |..|.|      .|..:|.|   .||.|...:...||..
Human  2024 PVLPSAVQKFSGTASSIIDEGLGEVGTVNEIDRRSTILPTAEVEGTKAPVEKEEVKVSGTVSTNF 2088

  Fly   960 PE----------------------ETTTVGQ-----------------ETTYDPEGSTTREDDTT 985
            |:                      |||:..|                 :|.:|.:..|..|..||
Human  2089 PQTIEPAKLWSRQEVNPVRQEIESETTSEEQIQEEKSFESPQNSPATEQTIFDSQTFTETELKTT 2153

  Fly   986 VAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDP-----EGSTTREDDTT-----VAIDTTT 1040
            .....||:|     |..|...:.||.|::...:|.||     |..||..:.|.     :|....|
Human  2154 DYSVLTTKK-----TYSDDKEMKEEDTSLVNMSTPDPDANGLESYTTLPEATEKSHFFLATALVT 2213

  Fly  1041 EKPEDDTTVEDSTPIPEESTTIAQETTYDPEG--STTREDDT----------------------- 1080
            |....:..|.|| ||.:|     :.|.:.|:|  .|.:|.||                       
Human  2214 ESIPAEHVVTDS-PIKKE-----ESTKHFPKGMRPTIQESDTELLFSGLGSGEEVLPTLPTESVN 2272

  Fly  1081 --------------TVAIE-TTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTV 1130
                          |..:| |:::|.||...:|:..  .|....|:|....:..||.|......:
Human  2273 FTEVEQINNTLYPHTSQVESTSSDKIEDFNRMENVA--KEVGPLVSQTDIFEGSGSVTSTTLIEI 2335

  Fly  1131 AIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTR--EEDTTVAIETTTEKPEDDTTV 1193
            ..||..|.|    ||   .|:| .||.:..     |:..|.|  ||..|...:|.||:   |:..
Human  2336 LSDTGAEGP----TV---APLP-FSTDIGH-----PQNQTVRWAEEIQTSRPQTITEQ---DSNK 2384

  Fly  1194 EDSTPIPEETTTVG-----------------------QETTYDPEG------------------- 1216
            ..||....||||..                       .:..|:|.|                   
Human  2385 NSSTAEINETTTSSTDFLARAYGFEMAKEFVTSAPKPSDLYYEPSGEGSGEVDIVDSFHTSATTQ 2449

  Fly  1217 STTREDDTTVAIDTTTEK----PEDDTTVEDSTP-----IPEESTTVAQDTTNDPEGSTTREDDT 1272
            :|.:|..||...|.:.||    |.......|..|     :|..|    :...:.|:.::|..:  
Human  2450 ATRQESSTTFVSDGSLEKHPEVPSAKAVTADGFPTVSVMLPLHS----EQNKSSPDPTSTLSN-- 2508

  Fly  1273 TVAIDTTTE-------KPEDDTTVEDSTPIPEES-------------TTVAQDTTNDPEGSTTRE 1317
            ||:.:.:|:       :..:|:|::.:...|.|:             .|:.:.|..:.....|.:
Human  2509 TVSYERSTDGSFQDRFREFEDSTLKPNRKKPTENIIIDLDKEDKDLILTITESTILEILPELTSD 2573

  Fly  1318 DDTTVAIDTT---------------TEKPED-----DTTVEDSTPIPE-----ESTTIAQET--- 1354
            .:|.:.||.|               ||.|.:     |.:.:|||.:.|     .:.::.:||   
Human  2574 KNTIIDIDHTKPVYEDILGMQTDIDTEVPSEPHDSNDESNDDSTQVQEIYEAAVNLSLTEETFEG 2638

  Fly  1355 -----------TYDPEGSTTREDDTT---VAIETTTEKPEDDTTVE--------DSTPIPEESTT 1397
                       |:|.  |.|.||.:.   :....||..|...|..|        .|.|||.:|.|
Human  2639 SADVLASYTQATHDE--SMTYEDRSQLDHMGFHFTTGIPAPSTETELDVLLPTATSLPIPRKSAT 2701

  Fly  1398 VAQD---------TTNDPEGSTTREEDTTVA-----------IETTTEKPED------------- 1429
            |..:         ..:|...|:|..:...:|           .|.|.|:.||             
Human  2702 VIPEIEGIKAEAKALDDMFESSTLSDGQAIADQSEIIPTLGQFERTQEEYEDKKHAGPSFQPEFS 2766

  Fly  1430 ---DTTVEDSTPIPEETTT--VGQETTYDP---EGST-TREDDTTVAIET----TTEKPEDDTTV 1481
               :..:.|.||.....||  :.|..|..|   |||. ....|||:|:.|    :::.|....|:
Human  2767 SGAEEALVDHTPYLSIATTHLMDQSVTEVPDVMEGSNPPYYTDTTLAVSTFAKLSSQTPSSPLTI 2831

  Fly  1482 ------EDSTPIPEETTT--------------------VAQETTYDPEGST---TRDDTTVAIET 1517
                  ...|.||:.:..                    |..|.|:.|....   ..:..:::.:|
Human  2832 YSGSEASGHTEIPQPSALPGIDVGSSVMSPQDSFKEIHVNIEATFKPSSEEYLHITEPPSLSPDT 2896

  Fly  1518 TTEKPEDDTTAE-----GSTP---IPDTSTTVNQD--TTTD-----ESSTVVTTTNIPKESTTLG 1567
            ..|..|||...|     .::|   |....|.:.||  ..||     |:..:..|...|:..|.:.
Human  2897 KLEPSEDDGKPELLEEMEASPTELIAVEGTEILQDFQNKTDGQVSGEAIKMFPTIKTPEAGTVIT 2961

  Fly  1568 DSTLSPGENSTAGQVSTSTTLVYDTTSSPIPSSSRSTTLEPSSSSSPE----------------- 1615
            .:.....|.:|....|||.:..|...:..:|..|..|:..|:.|||||                 
Human  2962 TADEIELEGATQWPHSTSASATYGVEAGVVPWLSPQTSERPTLSSSPEINPETQAALIRGQDSTI 3026

  Fly  1616 -------------------------TTTSSLPPLSC-----STGYQ-------------YLPHPT 1637
                                     .|..:.||.|.     .|.:.             |||.|.
Human  3027 AASEQQVAARILDSNDQATVNPVEFNTEVATPPFSLLETSNETDFLIGINEESVEGTAIYLPGPD 3091

  Fly  1638 NCHKYIHCSNGHELIMECPANLYWDYHKFVCSGDSGVCYNDTENSNPEEKVCGPG-------VDF 1695
            .| |...|.||                        |.|| .||.|  ....|.||       :||
Human  3092 RC-KMNPCLNG------------------------GTCY-PTETS--YVCTCVPGYSGDQCELDF 3128

  Fly  1696 -LAHPTDCTMYLQCSNGVALERKCPDPLY----WNPEIKSCDWSNKYCTNLRASQSISCAAGMNF 1755
             ..|...|.....|.:|....|....|.|    ...:.::||:                    .:
Human  3129 DECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDY--------------------GW 3173

  Fly  1756 NVFQSDCSKY 1765
            :.||..|.||
Human  3174 HKFQGQCYKY 3183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc68ENP_996064.1 ChtBD2 <1761..1791 CDD:214696 3/5 (60%)
ChtBD2 1626..1668 CDD:214696 10/59 (17%)
ChtBD2 1688..1734 CDD:214696 14/57 (25%)
VCANNP_004376.2 IG_like 29..147 CDD:214653
Ig_Versican 36..151 CDD:143309
Link_domain_CSPGs_modules_1_3 150..244 CDD:239594
Link_domain_CSPGs_modules_2_4 251..346 CDD:239597
GAG-alpha (glucosaminoglycan attachment domain) 348..1335 143/663 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..439
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 603..622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 807..829 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1154 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1316 15/46 (33%)
GAG-beta 1336..3089 366/1801 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1497 20/76 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1510..1539 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1717..1737 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1759..1789 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1962..1994 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2134 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2168..2188 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2371..2396 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2445..2473 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2493..2518 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2598..2617 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2834..2856 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2881..2905 4/23 (17%)
EGF_CA 3091..3125 CDD:238011 14/61 (23%)
EGF_CA 3127..3163 CDD:238011 9/35 (26%)
CLECT_CSPGs 3169..3292 CDD:153058 7/35 (20%)
CCP 3296..3352 CDD:153056
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3371..3396
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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