DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc68E and MUC17

DIOPT Version :9

Sequence 1:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001035194.1	Gene:	MUC17 / 140453	HGNCID:	16800	Length:	4493	Species:	Homo sapiens

Alignment Length:	1901	Identity:	528/1901 - (27%)
Similarity:	737/1901 - (38%)	Gaps:	483/1901 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ITSPTKIKSLPVEVENDRKDSSGIDTTVEDLTPIPEETTTVAQETTYDPEGSTTRED--DTTVAI 172
            :|:.|:.:|.|...|.....:|........||.||..||.|...     |.||....  ||:..:
Human  1721 VTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSS-----EASTLSATPIDTSTPV 1780

  Fly   173 ETTTEKPEDDTTVEDSTPIPEE----------STTVAQETTYDPEGSTTREDDTTVAIETTTEKP 227
            .|:||.....||.| .|.||..          ||.|:.....:.|.||.    :|..:::.:  |
Human  1781 TTSTEATSSPTTAE-GTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTL----STTPVDSNS--P 1838

  Fly   228 EDDTTVEDSTPIPEESTTVAQETTYDPEGSTTRDDETTVAIETTTEKPEDDTTVE-----DSTPI 287
            ...:|...|:|.|.|.|::|  |:...||||..   |::.:.|||....:..|:.     .|||:
Human  1839 VVTSTAVSSSPTPAEGTSIA--TSTPSEGSTAL---TSIPVSTTTVASSETNTLSTTPAVTSTPV 1898

  Fly   288 PEESTTVAQETTYDPEG---STTREDD---TTVAIETTTEKPED----DTTVEDS-TPIPEESTT 341
            ...:...:..||.|...   ||.||..   |::.:.|||....:    .||:.|: ||:...|..
Human  1899 TTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQA 1963

  Fly   342 VAQETTYD---------PEGST---------------------TREDDTTVAIETTTEKPEDDTT 376
            .:..||.|         .||||                     |...||:....|:||.....||
Human  1964 SSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTT 2028

  Fly   377 -----VEDSTPIPEESTT------VAQETTYDPEGST--TREDDTTVAIETTTEKPEDDTTVEDS 428
                 ::.||  |.|.||      |:.......||:|  |...|:...:..:|| .....|.|.|
Human  2029 AGGTSIQTST--PSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTE-ASSSATAEGS 2090

  Fly   429 --------------TPIPEESTTVAQETTYDPEGST--TREDDTTVAIETTTEKPEDDTTVEDST 477
                          |.||..:|.||     .||.||  |...|:...:.|:||        ..|:
Human  2091 SMTISAPSEGSPLLTSIPLSTTPVA-----SPEASTLSTTPVDSNSPVITSTE--------VSSS 2142

  Fly   478 PIPEESTTVAQETTYDPEGS--TTREDDTTV----AIETTTEKPED------DTTAEDSTPIPEE 530
            |||.|.|:: |.:||....:  |:....|||    ||.|.:..|.|      ::|...|:|...|
Human  2143 PIPTEGTSM-QTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSE 2206

  Fly   531 STTVAQDTTNDPEGST-------------TRED--------DTTVAIETTTEKPEDDTTAEDSTP 574
            .|::  .|:...||||             |.|.        ||:..:.|:||.....|||| .|.
Human  2207 GTSM--PTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAE-GTS 2268

  Fly   575 IP----EESTT------VAQETTYDPEGSTTREDDTTVAIETTTEKREDDTTVEDSTPIPEESTT 629
            ||    .|.||      |:.....:.|.||.    :|..:::.|   ...|:.|.|:|.|....|
Human  2269 IPTSTLSEGTTPLTSIPVSHTLVANSEVSTL----STTPVDSNT---PFTTSTEASSPPPTAEGT 2326

  Fly   630 VAQDTTNDPEGST--TREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQETTYDPEGST-T 691
             :..|:...||:|  ||...:|..:.:........|.|:.|||:          |||...||: |
Human  2327 -SMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPV----------TTYSQAGSSPT 2380

  Fly   692 REDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQETTYDPEGST--TREDDTTVAIETTTEK 754
            ..|||::...|.:         |.|||:  .|..|:.......|.||  |...||:..:.|:||.
Human  2381 TADDTSMPTSTYS---------EGSTPL--TSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEA 2434

  Fly   755 PEDDTTAEDS---TPIPEESTT------VAQDTTNDPEGST--TREDDTTVAIETTTEKREDDTT 808
            ....||||.:   |..|.|.||      |:.......|..|  |...||:..:.|:||.....||
Human  2435 SSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTT 2499

  Fly   809 VED--------------STPIPEETTTVGQETTYDPEGST--TREEDTTVAIETTTEKPEDDTTA 857
            .||              .|.||..||.|.     .||.||  |...|:...:.|:||.....|:|
Human  2500 AEDIVVPISTASEGSTLLTSIPVSTTPVA-----SPEASTLSTTPVDSNSPVVTSTEISSSATSA 2559

  Fly   858 -----------EDSTPIPEESTTVAQETTYDPEGST--TREDDTTVAMETTTEKREDDTTVED-S 908
                       |.|||:  .|..|:.:.....|.||  |...||::.:.|:||.....||.:| |
Human  2560 EGTSMPTSTYSEGSTPL--RSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTS 2622

  Fly   909 TPI--PEESTT------VAQDTTNDPEGST--TREEDTTVAIETTTEKPEDDTTVEDSTPIPEET 963
            .||  |.|.:|      |:.......|.||  |...||...:.|:|......||.|.|: :|  |
Human  2623 MPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSS-MP--T 2684

  Fly   964 TTVGQETT------------YDPEGST--TREDDTTVAIDTTTEKPEDDTTVED-----STP--- 1006
            :|.|:.:|            .:.|.||  |...||:..:.|:.|.....||.|.     |||
Human  2685 STPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDG 2749

  Fly  1007 -IPEESTTVAQDTTNDPEGST--TREDDTTVAIDTTTEKPEDDTTVEDS---TPIPEESTT--IA 1063
             .|..|..|:.......|.||  |...||::.:.|:||.....||.|.:   |..|.|::|  .:
Human  2750 STPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTS 2814

  Fly  1064 QETTYDPEGS------TTREDDTTVAIETTTEKPEDDTTVED--------------STPIPEEST 1108
            ....:.|..|      :|...||:..:.|:|:.....||.|.              .|.||..:|
Human  2815 MPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTT 2879

  Fly  1109 TVAQDTTNDPEGST--TREDDTTVAIDTTTEKPEDDTTVE-DSTPI--PEESTT------VAQDT 1162
            .||..     |.||  |...||::.:.|:||.....||.| .|.||  |.|.:|      |:...
Human  2880 PVASS-----EASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVP 2939

  Fly  1163 TNDPEGST--TREEDTTVAIETTTEKPEDDTTVED-----STPIPEETTTVGQETTYDP----EG 1216
            ....|.||  |...||...:.|:.|.....||.|.     |||....|.......:..|    |.
Human  2940 VAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEA 3004

  Fly  1217 STTRED--DTTVAIDTTTEKPEDDTTV-----------EDSTP---IPEESTTVAQDTTNDPEGS 1265
            ||....  ||:..:.|:||.....||.           |.|||   ||..:|.||     .||.|
Human  3005 STLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVA-----IPEAS 3064

  Fly  1266 TTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEGST---------------- 1314
            |.    :|..:|:.:  |...:|...|:|.|.|.|::...|.:  ||||
Human  3065 TL----STTPVDSNS--PVVTSTEVSSSPTPAEGTSMPISTYS--EGSTPLTGVPVSTTPVTSSA 3121

  Fly  1315 -----TREDDTTVAIDTTTEKPEDDTTVEDS---TPIPEESTTIAQETTYDPEGS---TTREDDT 1368
                 |...||:..:.|:||.....||.|.:   |..|.|.:|   ..||.|..:   .:.||.|
Human  3122 ISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGST---PLTYMPVSTMLVVSSEDST 3183

  Fly  1369 ------------TVAIETTTEKPEDDTTVEDSTP---------IPEESTTVAQDTTNDPEGS--T 1410
                        |.:.|.|:....:.|::..|||         :|..:|.||..     |.|  :
Human  3184 LSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASS-----EASILS 3243

  Fly  1411 TREEDTTVAIETTTEKPEDDTTV-----------EDSTPI---PEETTTVGQETTYDPEGSTTRE 1461
            |...|:...:.|:||......|.           |.|||:   |..||||....|  ...|||..
Human  3244 TTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSET--STLSTTPA 3306

  Fly  1462 DDTTVAIETTTEKPEDDTTVEDSTPIPEET--------TTVAQETT--YDPEG---STTRDDTTV 1513
            |.:|..  ||..:......:.|.|.:|..|        |.::..||  ...|.   |||..||:.
Human  3307 DTSTPV--TTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTST 3369

  Fly  1514 AIETTTEKPEDDTTA-----------EGSTPI--------PDTSTTVNQ-DTTTDESSTVVTTTN 1558
            .:.|:||.....|||           ||:||:        |..|:.||. .||..:|:|:|||:.
Human  3370 PVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTST 3434

  Fly  1559 IPKESTTLGDSTLSPGENSTAGQVSTSTTLVYDTTSSPIPSSSRST-TLEPSSSSSPETTTSSLP 1622
            ....|.|:.:.|..|  .||..:.||..::: ..:::|:.||..|| :..|..:|:|.||:|  |
Human  3435 EASSSPTIAEGTSLP--TSTTSEGSTPLSIM-PLSTTPVASSEASTLSTTPVDTSTPVTTSS--P 3494

  Fly  1623 PLSCSTGYQYLPHPTN 1638
            ..|..|..:....||:
Human  3495 TNSSPTTAEVTSMPTS 3510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696	3/13 (23%)
		ChtBD2	1688..1734	CDD:214696
MUC17	NP_001035194.1	SEA	4190..4276	CDD:279699
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910