DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc68E and Vcan

DIOPT Version :9

Sequence 1:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001164029.1	Gene:	Vcan / 114122	RGDID:	619940	Length:	3357	Species:	Rattus norvegicus

Alignment Length:	1965	Identity:	436/1965 - (22%)
Similarity:	712/1965 - (36%)	Gaps:	541/1965 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DTQYIKSRTSEKVSQLNLNKNNDTASKLKIGAPYYYQIKITSPTKIKSLPVEVENDRKDSSGIDT 135
            |||     |.|.|:|:...:.....:.::|.....::..:.:.|.::|..|.:|..:.|...:.|
  Rat   484 DTQ-----THESVTQIEQIEVGPLVTSMEITNHISFKEFLETKTPLESTEVTLEQHQTDMPTVIT 543

  Fly   136 TVEDLTPIPEETTTVAQETTYDPEGSTTREDD-TTVAIETTTEKPEDDTTVEDSTPIPEESTT-- 197
            :       ||..||    :.|   |.|.|||| ..:|:   |.:....|.|  .:.|||..|.
  Rat   544 S-------PELATT----SHY---GVTLREDDREDIAL---TVRSGQSTRV--FSQIPEVITVSK 589

  Fly   198 VAQETTYDPEGSTTREDDTTVAIETT--------TEKPEDDTTVED-------STPIPEESTTVA 247
            .:::|||...|........|:.:..|        .|...||.|.||       :.|.|.:..|..
  Rat   590 TSEDTTYSQLGDLEFVSTATITMLGTDGSLTDEGKEPQTDDKTAEDEFGQSQPTIPFPSQHLTEV 654

  Fly   248 QETTYDPEGSTTRDDETTVAIE--TTTEKPE---DDTTVEDSTPIPEES--------TTVAQETT 299
            :...|..:         |:::|  :|...|.   |.|...:.|.:|...        ..:.::.|
  Rat   655 ESLPYSGD---------TISVERISTVSYPSLQTDVTQGRERTEVPRPGLKKDPYAVDEIQEKIT 710

  Fly   300 YDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQETTYDPEGST---------- 354
            .||...|..|..:.:::.|::.:...:.|...|..:..|..||......|.:..|
  Rat   711 KDPFIGTIEEGFSGMSLSTSSSETSAERTESVSPALTIEKLTVKPAVASDVDEMTILTRLETDVP 775

  Fly   355 TREDDTT----------VAIETTTEKP--EDDTTVEDSTPIP-------EESTTVAQETT----Y 396
            |.::|.|          |.:.|..:.|  ||::|   |.|:|       .:|..|:..|.    .
  Rat   776 TSDEDVTSAHLTHSTLNVEVVTVLKWPGNEDNST---SKPLPPTERAGFTKSPPVSLSTVGIVGK 837

  Fly   397 DPE--GSTTREDDTTVAIETTTEKP------EDDTTVEDSTPIP-------EESTTVAQETTYDP 446
            |.|  ..|...|:.|:::: .|.||      ||.|:.|.:..||       .|.:|:.:.||.|.
  Rat   838 DKETPSFTDGGDEYTLSLD-GTPKPLEKFSEEDLTSGEFAVTIPTSISIDSAEKSTLGEPTTGDR 901

  Fly   447 EGSTTREDDTTVAIETTTEKPEDDTTVEDSTPI----PEESTTVAQETTYDPEGSTTREDDTTVA 507
            ..|||...|  :.|..|.|....|..::.|.|:    |...|:..:|:.: ...|:|::..|.|.
  Rat   902 VLSTTSTKD--LVINATVEGSALDEDMDASKPLFTATPFVHTSDVEESAF-VNYSSTQQPTTYVD 963

  Fly   508 IETTTEK---PEDD-TTAEDSTPIPEESTTVA-QDTTNDPEGSTTREDDTTVAIETTTEKPEDDT 567
            |..|:..   |:.: :.:|.|.|:.:|....: |||........|...:....||.|    :.:|
  Rat   964 ISHTSPLSIIPKTEWSVSETSVPLEDEVLGKSDQDTLEQTHLEATMSPEALSTIEVT----QGET 1024

  Fly   568 TAEDST---PIPEESTT--VAQETT-YDPEGSTTREDDTTVAIETTTEKREDDTTVEDSTPIPE- 625
            ..|..|   |.|..|:|  :.:||| ::.||            |.:|....:|..:.||..:|.
  Rat  1025 QEEPQTPGIPFPALSSTAVMTKETTAFEEEG------------EGSTYTLSEDRLMTDSEIVPSL 1077

  Fly   626 ESTTVAQDTTNDPEGSTTRED---DT----------TVAIETTTEKPEDDTTAEDSTP------- 670
            |:|.|.   |:.|.|:.|:::   ||          ||.:.|   :||....||.|:|
  Rat  1078 ETTPVG---TSYPGGAMTQQEVEMDTMVTQMSSIRPTVVLST---EPEVSYEAEGSSPMEFASTL 1136

  Fly   671 ---------IPEESTTVAQETTYD-----------------PEGSTTREDDTTVAIETTTEKPED 709
                     :.||:|...::|..|                 |:.|.|..|   :::.|..:....
  Rat  1137 KPFGTQVTQLVEETTEEGKKTPLDYTDLGSGLFEQPRVTELPDFSMTPSD---ISVFTAIDSLHR 1198

  Fly   710 DTTVEDSTPIPEE----STTVAQETTYD---PEGSTTREDDTTVAIETTTEKPEDDTTAE----D 763
            .|.:...:|..||    ....:::||.|   |..|.|:...||: ::...:|.|.|...|    .
  Rat  1199 TTPLRPPSPFTEEPHIFEKEPSEKTTGDIILPRESVTQHPLTTL-MDIIAKKTESDIDHEYHMTS 1262

  Fly   764 STPI--PEESTTVAQDTTNDP--------------------------EGSTTREDDTTV-AIETT 799
            ..|:  |...:.|.:.||:.|                          |..|.|..|..| .....
  Rat  1263 KPPVMQPTRPSVVERKTTSKPQELSTSPPPAGTKFHPDINVYIIEVRENKTGRMSDMVVNGHPID 1327

  Fly   800 TEKREDDTTVEDSTPIPEETTTVGQE-------TTYDPEGSTTREED--------TTVAIETTTE 849
            :|.:|::...|::.|:.:....:..|       ..|..|.....|||        ||.:::..|.
  Rat  1328 SESKEEEPCSEETDPLHDLFAEILPELPDSFEIDIYHSEEDEDGEEDCVNATDVTTTPSVQYITG 1392

  Fly   850 KPEDDTTA-------------EDSTPIPEESTTVAQET----TYDPEGST----TREDDTTVAME 893
            ||...|..             |...|....|.|.|.:|    ..:.|.||    |:..:.|..:|
  Rat  1393 KPHVTTVPKNPEAAEARRGLYESVAPSQNFSNTSATDTHQFIPAETELSTTMQFTKSKEATELLE 1457

  Fly   894 TTTEKREDDTTVEDSTPIPEESTTVAQD---TTNDPEGSTTREEDTTVAIETTTEKPEDDTTVED 955
            .|.:.       |.....||..::...|   |....:|.||:..:........||.||.    :.
  Rat  1458 ITWKP-------ETYPETPEHFSSGEPDVFPTLPSHDGKTTKWSEFITESNPNTENPEH----KQ 1511

  Fly   956 STPI---PEE--------------------TTTVGQETTYDPEGSTTREDDTTVAIDTTTEKP-- 995
            ..||   |||                    ...:|:||...|..||:.....:|::....|.|
  Rat  1512 PKPIPLFPEEFSGEGAIDQASQQTIFSRATEVALGKETDQSPTISTSSIRSGSVSVHALEEDPIA 1576

  Fly   996 --------EDDTTVEDSTPIPEESTTVAQDTTNDP--EGSTTREDDTTVAIDTTTEKPEDDTTVE 1050
                    |..:|||....:....|.....:::.|  |||...|:.|....:|.|:.|:.:.| :
  Rat  1577 LTGISQTDESMSTVESWVEMTPSQTVEFSGSSSAPTIEGSGEVEEYTNKIFNTVTDLPQREPT-D 1640

  Fly  1051 DSTPIPEESTTIAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQDTT 1115
            ...|:...:..|.....|.|  :||...|:  .:.:|..:|         |....::||....::
  Rat  1641 TLIPLDMSNIMITDHHIYTP--ATTAPLDS--QLPSTDARP---------TQFGIQTTTSEWVSS 1692

  Fly  1116 NDPEGSTTRED---DTTVA----IDTTTEKPE--------DDTTVEDSTP-------IPEESTTV 1158
            ...||..|.||   ||..|    :...||:.:        :.:.|..|:|       :||.::||
  Rat  1693 TSFEGRKTEEDKERDTNAAHTGEVQPATERSDRLLLTSELESSNVAASSPLDTWEGFVPETTSTV 1757

  Fly  1159 AQDTTNDPEGSTTREEDTTVAIETTTEKPEDDTTVEDSTP----IPEETTTVGQETT---YDPEG 1216
                 ::.|.:.|    |.|..||:.....:..:.|.|:.    :.||.||:..:..   .|...
  Rat  1758 -----SEKEMANT----TPVFTETSDVANLETQSFEHSSSSQPRVQEELTTLSGKPPLIFMDLGS 1813

  Fly  1217 STTREDDTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEG---STTREDDTTVAIDT 1278
            .....|...:...:.|...|.||.|:...| ...|.:|...::::|.|   ||..:.:....::.
  Rat  1814 GDASTDMEFITASSFTLDLESDTKVKKELP-STLSPSVETSSSSEPIGLAPSTVLDIEIVEVMNQ 1877

  Fly  1279 TTE---------KPEDDTTVEDSTPIPEESTTVAQDTTNDPE-----GSTTREDDTTVAIDTTTE 1329
            |::         ||.....|.|..|      .:.:|.:.|..     .|||.:::|.....:..|
  Rat  1878 TSKKTLISELSGKPTSQAEVRDLYP------GLGEDFSGDSSEYPTVSSTTMKEETVGMGGSENE 1936

  Fly  1330 KPEDDTTV-------EDSTPIPEE---STTIAQETTY-------DPEG-----STTREDDTTVA- 1371
            :.:|..|:       ::..|:|:.   .:|:|..|.:       ..||     |:.|...:.|.
  Rat  1937 RVKDTQTLSSIPPTSDNINPVPDSKGFGSTVASTTAFPWEEFMTSAEGSGEELSSVRSSVSLVLP 2001

  Fly  1372 ----IETTTEKPEDDTTVEDST-----------PIPEESTTVAQDTTNDPEGSTTREEDTTVAIE 1421
                |..|||.|..|...|::.           ||.....||......|.|.::|...|....:|
  Rat  2002 LGVDILPTTESPYFDQEFEEAAAVTEAGKQSALPIAVSGNTVDLTENRDIEVNSTMSVDLPQTME 2066

  Fly  1422 TTT--EKPE---------DDTTVED------------STPIPEETTTVGQ-------ETTYDPEG 1456
            ...  .|||         .:|..:|            |:..||:||...|       :|:|....
  Rat  2067 PAKLWSKPEVNPEKQEIGSETVTQDKAQGQKSFESLHSSLAPEQTTLESQSLIETEVQTSYYSML 2131

  Fly  1457 STTREDDTTVAIETTTEKPEDDTTVED-STP------------IPEET------TTVAQETTYDP 1502
            :|.:..:|...:|      |:.|::.. |||            .||.|      :..|..|...|
  Rat  2132 TTMKTYNTNEEVE------EEGTSIAHMSTPGPGIKGLESYPTHPEATGKSYSFSASALVTESGP 2190

  Fly  1503 EGSTTRDDTTVAIET----------TTEKPEDDT------TAEGSTPIPDTSTTVNQDTTTDESS 1551
            ..|...|.:|...|:          |.::...|.      :.|...|:|.||.::     ||...
  Rat  2191 ARSVVMDSSTQEEESIKLFQKDMILTHKESNSDLSFSGLGSGEALPPLPTTSVSL-----TDMGK 2250

  Fly  1552 TVVTTTNIPKES--TTLGDSTLSPG-------ENSTAGQVSTSTTLVYDTTSSPIPSSSRSTTLE 1607
              :.:|..|:.|  .:||.|.|...       .|.....:|.:.::..|:|.:|      :|||
  Rat  2251 --INSTLYPETSHMESLGTSILGDNHERMKNVSNEVRTLISETGSISQDSTEAP------NTTL- 2306

  Fly  1608 PSSSSSPETTTSSLP 1622
             |.:.:.|:|||.||
  Rat  2307 -SDTRTEESTTSPLP 2320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696
		ChtBD2	1688..1734	CDD:214696
Vcan	NP_001164029.1	IG_like	30..147	CDD:214653
		Ig_Versican	36..151	CDD:143309
		Link_domain_CSPGs_modules_1_3	150..244	CDD:239594
		Link_domain_CSPGs_modules_2_4	251..346	CDD:239597
		EGF_CA	3052..3086	CDD:238011
		EGF_CA	3088..3124	CDD:238011
		CLECT_CSPGs	3130..3253	CDD:153058
		CCP	3257..3313	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000