DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk5 and SCNN1G

DIOPT Version :9

Sequence 1:	NP_996138.2	Gene:	ppk5 / 2768987	FlyBaseID:	FBgn0053289	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001030.2	Gene:	SCNN1G / 6340	HGNCID:	10602	Length:	649	Species:	Homo sapiens

Alignment Length:	542	Identity:	115/542 - (21%)
Similarity:	199/542 - (36%)	Gaps:	125/542 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKSKV 80
            ||......: ||:|:....|....|.        :.:|.|: ...::.||.:|:||:|..|.|.|
Human    56 WIGFTLTAV-ALILWQCALLVFSFYT--------VSVSIKV-HFRKLDFPAVTICNINPYKYSTV 110

  Fly    81 EHLMPG---SIRYAMLQKTCYKESNFSQYMD-----TQHRNETFSN----FILDVSE--KCADL- 130
            .||:..   ..|.|:.....:.||...:..:     ::.:...||:    .|.|..|  |..|.
Human   111 RHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFF 175

  Fly   131 ------IVSCIFHQ----QRIPCTDI--FRETFVDEGLCCIF------NVLHPYYLYKFKS---- 173
                  :...|.|:    ..|....:  |:....|...|..:      |.:..:|...:.:
Human   176 TGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQ 240

  Fly   174 -PYIRDFTSSDRFADIAVD--WDPISGYPQRLPSSYYPRPG-----------------VGVGTSM 218
             |..:....|....::.|.  :|.:|...:.....::|..|                 :| |:..
Human   241 VPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMG-GSEY 304

  Fly   219 GLQIVLNGHVDDYFCSSTNGQGFKILLYNPIDQPRMKESGLPV------MIG-HQT-SFRIIARN 275
            |||::|..:.::|.....:..|.|::::...:.|.:::.|..:      .|| |.| ||::....
Human   305 GLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPY 369

  Fly   276 VEATPS-----IRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSMFFLRLCSCIPYYLPLIY 335
            .:.|..     ||||:...                |:.:.|...|.....:..|.|..|..|| .
Human   370 SQCTEDGSDVPIRNIYNAA----------------YSLQICLHSCFQTKMVEKCGCAQYSQPL-P 417

  Fly   336 PNASVCD-------VFHFECLNRAESQIFDLQSSQCKEFC------LTSCHDLIFFPDAFS---- 383
            |.|:.|:       ::.:..|:||..|......|.|||.|      ||:  .|..:|...|
Human   418 PAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTT--SLAQWPSVVSEKWL 480

  Fly   384 TPFSQKDVKAQTNYLTNFSSEYMRKNLAVVNFFHTDNYFRSSVRTSYTGPTEYMASTGGIMSLMI 448
            .|....|...|.|...|      :.:||.:..|:.|...||.:.:........:::.||.:.|.:
Human   481 LPVLTWDQGRQVNKKLN------KTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWM 539

  Fly   449 GFSVIFLAEII--YIILFVSTL 468
            ..||:.:.|||  :.|.|.|.:
Human   540 SCSVVCVIEIIEVFFIDFFSII 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	112/532 (21%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	115/542 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650