Protein Alignment ppk5 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_996138.2
• Gene: ppk5 / 2768987
• FlyBaseID: FBgn0053289
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 112/577 - (19%)
• Similarity: 203/577 - (35%)
• Gaps: 190/577 - (32%)

  Fly    15 WWIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKSK 79
            |::   ..::||.::.....:.:..|..|:   |.:.:|.....:|   ||.:|:||.:..|.||
Human    71 WFL---LTLLFAALVCWQWGIFIRTYLSWE---VSVSLSVGFKTMD---FPAVTICNASPFKYSK 126

  Fly    80 VEHLMP--GSIRYAMLQK---------TCYKESNFSQYMDT-----QHRNE-------------- 114
            ::||:.  ..:..|:|::         ...:..|||.:..|     ..||.
Human   127 IKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHN 191

  Fly   115 -------------------------------TFSNF--------------------------ILD 122
                                           ||.||                          :::
Human   192 GLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVE 256

  Fly   123 VSEKCADLIVSCIFHQQRIPC-----TDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSS 182
            :|.....:|::|:|..:  ||     |.||   :...|.|.|||
Human   257 MSYPGEQMILACLFGAE--PCNYRNFTSIF---YPHYGNCYIFN--------------------- 295

  Fly   183 DRFADIAVDWDPISGYPQR-LPSSYYPRPGVGVGTSMGLQIVLNGHVDDY--FCSSTNGQGFKIL 244
                     |    |..:: |||:       ..||..||:::|:...:||  |.:||  .|.:::
Human   296 ---------W----GMTEKALPSA-------NPGTEFGLKLILDIGQEDYVPFLAST--AGVRLM 338

  Fly   245 LYNPIDQPRMKESGLPVMIGHQTSFRIIARNVEA-----TPSIRNIHRTKRQCIFSDEQELLFYR 304
            |:.....|.:::.|:..|.|.:||..::...::.     :|...|......|..:||     :..
Human   339 LHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSD-----YNT 398

  Fly   305 YYTRRNCEAECDSMFFLRLCSCIPYYLPLIYPNASVCDVFHFECLNR---------AESQIFDLQ 360
            .|:.:.|...|.....:|.|:|..|..||  |....      .|.||         ::.|:...|
Human   399 TYSIQACLRSCFQDHMIRNCNCGHYLYPL--PRGEK------YCNNRDFPDWAHCYSDLQMSVAQ 455

  Fly   361 SSQCKEFCLTSCHDLIF--------FPDAFSTPFSQKDVKAQTNYLTNFSSEYMRKNLAVVNFFH 417
            ...|...|..||:|..:        :|...|..:....:..:.:..||.:  ..||.:..:|.:.
Human   456 RETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNIT--LSRKGIVKLNIYF 518

  Fly   418 TDNYFRSSVRTSYTGPTEYMASTGGIMSLMIGFSVIFLAEIIYIIL-FVSTLLLILI 473
            .:..:|:...::.......:::.||.....:|.||:.|.|...||: ||...::.|:
Human   519 QEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLV 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:459966	107/561 (19%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	112/577 (19%)