Protein Alignment ppk5 and SCNN1A

DIOPT Version :9

• Sequence 1: NP_996138.2
• Gene: ppk5 / 2768987
• FlyBaseID: FBgn0053289
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 109/567 - (19%)
• Similarity: 208/567 - (36%)
• Gaps: 146/567 - (25%)

  Fly     4 LKYVISDNNYSWWIKLYFAIIFALVLFVAVNLAVG-IYNKWDSTPVIIGISSKMTPIDQIPFPTI 67
            ::.|.|.:|.   :|..|..:..|..|..:....| ::.::.|.||.:.|:...   |::.||.:
Human   131 IRLVCSQHNR---MKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNS---DKLVFPAV 189

  Fly    68 TVCNMNQAK----KSKVEHLMPGSIRYAMLQKT---CYKESNFSQYM-------DTQ-------- 110
            |:|.:|..:    |.::|.|      ..:.::|   .||.|:|:..:       |.:
Human   190 TICTLNPYRYPEIKEELEEL------DRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQ 248

  Fly   111 -----------HRNETFSNFILDVS------------EKCADLIVSCIFHQQRIPCTDIFRETFV 152
                       .|..:.::.:.|.:            :.|......| |:|......|..||.:.
Human   249 RLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDC-FYQTYSSGVDAVREWYR 312

  Fly   153 DEGLCCIFNVLH--PYYLYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQRLPSSYY-------- 207
            ..    ..|:|.  |..|...:...:.:|..:.||..::.:....|.:...:..:.|
Human   313 FH----YINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNS 373

  Fly   208 -----PRPGVGVGTSMGLQIVLNGHVDDYFCSSTNGQGFKILLYNPIDQPRMKESGLPVMIGHQT 267
                 ..||:    :.||.::|....:|:....:...|.:::::...:...|.:.|..:..|.:|
Human   374 NLWMSSMPGI----NNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVET 434

  Fly   268 SFRI--------------IARNVEATPSIRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSM 318
            |..:              ..:|....| :.|::.:|                ||::.|...|...
Human   435 SISMRKETLDRLGGDYGDCTKNGSDVP-VENLYPSK----------------YTQQVCIHSCFQE 482

  Fly   319 FFLRLCSCIPYYLPLIYP---NASVCDVFHFE----CLNRAESQIFDLQS------SQCKEFCLT 370
            ..::.|.|.  |  :.||   |...||.....    |..:.:   .|..|      ::|::.|..
Human   483 SMIKECGCA--Y--IFYPRPQNVEYCDYRKHSSWGYCYYKLQ---VDFSSDHLGCFTKCRKPCSV 540

  Fly   371 SCHDLIF----FPDAFSTPFSQKDVKAQTNYLTNFSSEYMRKNLAVVN-FFHTDNYFRSSVRTSY 430
            :.:.|..    :|...|..:..:.:..|.||..|    ..|..:|.|| ||...||..:|...|.
Human   541 TSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVN----NKRNGVAKVNIFFKELNYKTNSESPSV 601

  Fly   431 TGPTEYMASTGGIMSLMIG---FSVIFLAEIIYIILFVSTLLLILIF 474
            |..| .:::.|...||..|   .||:.:||:::.:|.:..|:|:..|
Human   602 TMVT-LLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRF 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:279230	105/551 (19%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	109/567 (19%)
		deg-1	121..631	CDD:273309	104/549 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152177
Domainoid	1	1.000	105	1.000	Domainoid score	I6644
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I4949
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800