Protein Alignment ppk5 and Asic5

DIOPT Version :10

• Sequence 1: NP_996138.2
• Gene: ppk5 / 2768987
• FlyBaseID: FBgn0053289
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_067345.1
• Gene: Asic5 / 58170
• MGIID: 1929259
• Length: 495
• Species: Mus musculus
• Alignment Length: 504
• Identity: 109/504 - (21%)
• Similarity: 195/504 - (38%)
• Gaps: 141/504 - (27%)

  Fly    23 IIFALVLFVAVNLAV-GIYNK------WDSTPVIIGISSKMTPIDQIPFPTITVCNMNQAKKSKV 80
            :|:..|:..:|:|.| .||::      |.:|     .|.::..:::|.||.:|:||:|:.:...|
Mouse    63 VIWLAVVLGSVSLLVWQIYSRLVNYFTWPTT-----TSIEVQYVEKIEFPAVTLCNLNRFQTEAV 122

  Fly    81 EHLMPGSI--------RYAMLQKTCYKESNFSQYMD--TQHRNETFSNFI------LDVSEKCAD 129
            ...  |.|        :...||:.....:...:.:|  |.|:|.:.:.|:      |:     .|
Mouse   123 SRF--GIIFFLWDIVSKVLRLQEISANNTGSPETLDFVTNHQNFSITEFVKNNGFYLN-----ND 180

  Fly   130 LIVSCIFHQQRIPCTDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSSDRFADIAVDWDP 194
            .:|.|.|..:.....| |:..|.:.|.|..||             |..:..:.::.:
Mouse   181 TLVHCEFFGKTCSPKD-FKHVFTEYGNCFTFN-------------YGENIQNKNKVS-------- 223

  Fly   195 ISGYPQRLPSSYYPRPGVGVGTSMGLQIVLNGHVDDYFCSSTNG---QGFKILLYNPIDQPRMKE 256
            :||                    .||:::|:.|.:::..:...|   .|...::::|..:|:...
Mouse   224 VSG--------------------RGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDG 268

  Fly   257 SGLPVMIGHQTSFRIIARNV----------EATPSIRNIHRTKRQCIFSDEQELLFYRYYTRRNC 311
            .||...:|...  |:..|.:          |..|:|:                |..:..|:...|
Mouse   269 LGLSSPVGMHA--RVTIRQLKTVHQEYPWGECNPNIK----------------LRNFITYSTYGC 315

  Fly   312 EAECDSMFFLRLCSCIPYYLPLIYPNASVCDVF-HFECLNRAESQIFD--LQSSQC-----KEFC 368
            ..||.:....|||.|:|:.||   .|...||:. ::.|:    |.|.|  .:...|     ...|
Mouse   316 LKECKARHIQRLCGCLPFLLP---GNGVECDLLEYYNCV----SPILDHIERKGLCTMGTHNSSC 373

  Fly   369 LTSCHDLIF--------FPDAFSTPFSQKDVKAQTNYLTNFSSEYMRKNLAVVNFFHTDNYFRSS 425
            ..||.:..:        ||...:|.|..|.:        |.|.||:|:||..:...::|..::.:
Mouse   374 PVSCEETEYPATVSYSTFPSQRATRFLAKKL--------NQSQEYIRENLVNIEINYSDLNYKIT 430

  Fly   426 VRTSYTGPTEYMASTGGIMSLMIGFSVIFLAEIIYIILFVSTLLLILIF 474
            .:.......|.:|..||.:.|..|.|:|.:.|||.  .|.:....:|||
Mouse   431 QQQKAVSVPELLADVGGQLGLFCGASLITIIEIIE--YFFTNFYWVLIF 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:459966	104/488 (21%)
Asic5	NP_067345.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	105/491 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)