Protein Alignment ppk5 and ASIC4

DIOPT Version :10

• Sequence 1: NP_996138.2
• Gene: ppk5 / 2768987
• FlyBaseID: FBgn0053289
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_054198812.1
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 666
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 103/479 - (21%)
• Similarity: 174/479 - (36%)
• Gaps: 106/479 - (22%)

  Fly    15 WWIKLYFAIIFALVLFVAVNLAVGIYNKWDSTPVIIGISSKMTPIDQIP---FPTITVCNMNQAK 76
            |.:.|..::  |..|:.|..||.|...:    |.::.    |.|....|   ||.:|:||:|:.:
Human   197 WALALLTSL--AAFLYQAAGLARGYLTR----PHLVA----MDPAAPAPVAGFPAVTLCNINRFR 251

  Fly    77 KSKVE-----HLMPGSIRYAMLQKTCYKESNFSQYMDTQHRNETFSNFILDVSEKCADLIVSCIF 136
            .|.:.     ||       |.|.....|:.:..:....::......:.:.....:.||::.||.|
Human   252 HSALSDADIFHL-------ANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNF 309

  Fly   137 HQQRIPCTDIFRETFVDEGLCCIFNVLHPYYLYKFKSPYIRDFTSSDRFADIAVDWDPISGYPQR 201
            .......:: |...:...|.|..||.                              ||.|..|.|
Human   310 SGHHCSASN-FSVVYTRYGKCYTFNA------------------------------DPRSSLPSR 343

  Fly   202 LPSSYYPRPGVGVGTSMGLQIVLNGHVDDY--FCSSTN----GQGFKILLYNPIDQPRMKESGLP 260
                     ..|:|:  ||:|:|:...::|  ....||    ..|.::.:::..:.|.:.:.|..
Human   344 ---------AGGMGS--GLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFG 397

  Fly   261 VMIGHQTSFRIIARNVEATPSIRNIHRTKRQCIFSDEQELLFYRYYTRRNCEAECDSMFFLRLCS 325
            |..|.||......:.:...|......|.:.:.   .|.||..|..|:...|...|:....|:.|.
Human   398 VSPGFQTFVSCQEQRLTYLPQPWGNCRAESEL---REPELQGYSAYSVSACRLRCEKEAVLQRCH 459

  Fly   326 CIPYYLPLIYPNASVCDV-FHFECLNRAESQIFDLQSSQCKEFCLTSCH--------DLIFFPDA 381
            |...::|   .|.::|.. .:.||.:.....:.......|  ||.|.|:        .::..|:
Human   460 CRMVHMP---GNETICPPNIYIECADHTLDSLGGGPEGPC--FCPTPCNLTRYGKEISMVRIPN- 518

  Fly   382 FSTPFSQKDVKAQTNYLT---NFSSEYMRKNLAVVN-FFHTDNYFRSSVRTSYTGPTEYMASTGG 442
                      :....||.   |.:..|:|:|..|:: ||..........|.:| |.:..:...||
Human   519 ----------RGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAY-GLSALLGDLGG 572

  Fly   443 IMSLMIGFSVIFLAEIIYIILFVS 466
            .|.|.||.|::.|.||:..|..||
Human   573 QMGLFIGASILTLLEILDYIYEVS 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk5	NP_996138.2	ASC	4..460	CDD:459966	100/471 (21%)
ASIC4	XP_054198812.1	ENaC	167..615	CDD:273304	103/479 (22%)